Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor

scientific article published on 22 May 2015

Targeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1634/THEONCOLOGIST.2014-0465
P8608Fatcat IDrelease_rqzpcxiv3beevjrfokqq5k3tmi
P932PMC publication ID4571783
P698PubMed publication ID26001391
P5875ResearchGate publication ID277079311

P50authorAlex A AdjeiQ107055463
P2093author name stringYujie Zhao
P2860cites workVEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complexQ24293027
VEGF-Trap: a VEGF blocker with potent antitumor effectsQ24535043
Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasisQ24608039
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitorsQ24676378
Therapeutic options targeting angiogenesis in nonsmall cell lung cancerQ26823727
Vandetanib for the treatment of medullary thyroid cancerQ26824828
Lessons learned from the bevacizumab experienceQ26852509
Anti-vascular endothelial growth factor therapy in breast cancerQ26999473
MET: a critical player in tumorigenesis and therapeutic targetQ27008925
BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacyQ27650860
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancerQ27851554
Sorafenib in advanced hepatocellular carcinomaQ27861075
AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancerQ28251373
R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathwaysQ28275289
Sunitinib versus interferon alfa in metastatic renal-cell carcinomaQ28282757
AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imagingQ28293708
Vascular endothelial growth factor is a secreted angiogenic mitogenQ28646475
Molecular mechanisms and clinical applications of angiogenesisQ29547314
Angiogenesis: an organizing principle for drug discovery?Q29614538
Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumorsQ29615445
Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized phase III trialQ29615711
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trialQ29620127
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesisQ29620559
Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trialQ29620687
Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trialQ29620917
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancerQ29622818
Cediranib with mFOLFOX6 versus bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: a double-blind, randomized phase III study (HORIZON III).Q30317994
Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinomaQ30472055
AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.Q30490422
Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastomaQ30661157
New agents on the horizon in hepatocellular carcinomaQ38074429
Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapyQ38087230
Multifarious functions of PDGFs and PDGFRs in tumor growth and metastasisQ38115027
Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancerQ38125964
Understanding and targeting resistance to anti-angiogenic therapiesQ38133568
Anti-angiogenic drugs and biomarkers in non-small-cell lung cancer: a 'hard days night'.Q38153830
Critical appraisal of ramucirumab (IMC-1121B) for cancer treatment: from benchside to clinical use.Q38166329
Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma.Q38175454
Dovitinib versus sorafenib for third-line targeted treatment of patients with metastatic renal cell carcinoma: an open-label, randomised phase 3 trial.Q38189898
RET revisited: expanding the oncogenic portfolioQ38190360
Maintenance capecitabine and bevacizumab versus bevacizumab alone after initial first-line bevacizumab and docetaxel for patients with HER2-negative metastatic breast cancer (IMELDA): a randomised, open-label, phase 3 trial.Q39120399
Regorafenib inhibits growth, angiogenesis, and metastasis in a highly aggressive, orthotopic colon cancer modelQ39160279
Study of the cellular mechanism of Sunitinib mediated inactivation of activated hepatic stellate cells and its implications in angiogenesisQ39186341
Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistanceQ39212474
PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cellsQ39433494
Antitumor activity of BIBF 1120, a triple angiokinase inhibitor, and use of VEGFR2+pTyr+ peripheral blood leukocytes as a pharmacodynamic biomarker in vivoQ39623814
Expression of platelet-derived growth factor (PDGF)-B and PDGF-receptor β is associated with lymphatic metastasis in human gastric carcinomaQ39681377
Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5.Q40192837
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft modelsQ40198053
Tumor-driven paracrine platelet-derived growth factor receptor alpha signaling is a key determinant of stromal cell recruitment in a model of human lung carcinomaQ40283618
Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cellsQ40959364
Effect of small angiokinase inhibitor nintedanib (BIBF 1120) on QT interval in patients with previously untreated, advanced renal cell cancer in an open-label, phase II studyQ43657215
Brivanib versus sorafenib as first-line therapy in patients with unresectable, advanced hepatocellular carcinoma: results from the randomized phase III BRISK-FL studyQ43691230
Primary results of ROSE/TRIO-12, a randomized placebo-controlled phase III trial evaluating the addition of ramucirumab to first-line docetaxel chemotherapy in metastatic breast cancer.Q44304174
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanismsQ44680981
Phase I study of dovitinib (TKI258), an oral FGFR, VEGFR, and PDGFR inhibitor, in advanced or metastatic renal cell carcinomaQ45143413
Sorafenib for treatment of renal cell carcinoma: Final efficacy and safety results of the phase III treatment approaches in renal cancer global evaluation trial.Q46006772
Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene familyQ46135963
E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibitionQ46944486
Sorafenib inhibits the angiogenesis and growth of orthotopic anaplastic thyroid carcinoma xenografts in nude mice.Q53545899
Randomised, double-blind trial of carboplatin and paclitaxel with daily oral cediranib or placebo in patients with advanced non-small cell lung cancer: NCIC Clinical Trials Group study BR29.Q54410290
Bevacizumab plus chemotherapy versus chemotherapy alone as second-line treatment for patients with HER2-negative locally recurrent or metastatic breast cancer after first-line treatment with bevacizumab plus chemotherapy (TANIA): an open-label, randoQ57579457
Cediranib Plus FOLFOX/CAPOX Versus Placebo Plus FOLFOX/CAPOX in Patients With Previously Untreated Metastatic Colorectal Cancer: A Randomized, Double-Blind, Phase III Study (HORIZON II)Q58023765
The role of fibroblast growth factors in vascular developmentQ78384186
Comprehensive dissection of PDGF-PDGFR signaling pathways in PDGFR genetically defined cellsQ33386807
A phase I, open-label dose-escalation study of continuous treatment with BIBF 1120 in combination with paclitaxel and carboplatin as first-line treatment in patients with advanced non-small-cell lung cancerQ33399785
Rapid angiogenesis onset after discontinuation of sunitinib treatment of renal cell carcinoma patientsQ33588739
(Pre-)clinical pharmacology and activity of pazopanib, a novel multikinase angiogenesis inhibitorQ33590458
Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistanceQ33627739
Complete longitudinal analyses of the randomized, placebo-controlled, phase III trial of sunitinib in patients with gastrointestinal stromal tumor following imatinib failureQ33648995
Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastomaQ34038480
Phase I study of the angiogenesis inhibitor BIBF 1120 in patients with advanced solid tumors.Q34089525
Phase I open-label study of continuous treatment with BIBF 1120, a triple angiokinase inhibitor, and pemetrexed in pretreated non-small cell lung cancer patientsQ34114767
Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid TumorsQ34129930
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapyQ34157098
Cabozantinib in progressive medullary thyroid cancerQ34185084
The discovery of placenta growth factor and its biological activity.Q34245619
Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switchQ34282342
A randomised, double-blind phase III study of pazopanib in patients with advanced and/or metastatic renal cell carcinoma: final overall survival results and safety update.Q34322740
PDGF-BB induces intratumoral lymphangiogenesis and promotes lymphatic metastasisQ34359534
Targeting the PDGF signaling pathway in tumor treatmentQ34393461
Pharmacokinetics and metabolism of BIBF 1120 after oral dosing to healthy male volunteersQ34626130
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial.Q34633525
Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trialQ34638316
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimenQ34642136
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trialQ34645665
Axitinib versus sorafenib as second-line treatment for advanced renal cell carcinoma: overall survival analysis and updated results from a randomised phase 3 trialQ34650664
Docetaxel plus nintedanib versus docetaxel plus placebo in patients with previously treated non-small-cell lung cancer (LUME-Lung 1): a phase 3, double-blind, randomised controlled trialQ34658812
Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial.Q34662482
Biomarkers for anti-angiogenic therapy in cancer.Q34695003
Role of anti-angiogenesis therapy in the management of hepatocellular carcinoma: The jury is still out.Q34728237
Discovery of brivanib alaninate ((S)-((R)-1-(4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy)propan-2-yl)2-aminopropanoate), a novel prodrug of dual vascular endothelial growth factor receptor-2 and fibroblast groQ34752683
Linifanib versus Sorafenib in patients with advanced hepatocellular carcinoma: results of a randomized phase III trialQ34786090
Pharmacodynamic and pharmacogenetic angiogenesis-related markers of first-line FOLFOXIRI plus bevacizumab schedule in metastatic colorectal cancerQ34806780
Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinaseQ34819659
Adverse effects of anticancer agents that target the VEGF pathwayQ34990961
Regorafenib effects on human colon carcinoma xenografts monitored by dynamic contrast-enhanced computed tomography with immunohistochemical validationQ35010176
A phase I open-label dose-escalation study of oral BIBF 1120 combined with standard paclitaxel and carboplatin in patients with advanced gynecological malignanciesQ35011280
The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancerQ35021680
Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLCQ35050210
Rapid vascular regrowth in tumors after reversal of VEGF inhibitionQ35052385
Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma modelsQ35163538
Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trialQ35195766
The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesisQ35563524
Phase I study of BIBF 1120 with docetaxel and prednisone in metastatic chemo-naive hormone-refractory prostate cancer patients.Q35623311
Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesisQ35791487
PDGF receptor kinase inhibitors for the treatment of PDGF driven diseasesQ35811090
Angiopoietins in tumours: the angiogenic switchQ35861359
Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.Q35966757
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesisQ36111400
Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasisQ36300824
The VEGF pathway in cancer and disease: responses, resistance, and the path forward.Q36526512
Structure and physiology of the RET receptor tyrosine kinaseQ36555201
Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancerQ36822111
Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trialQ36910409
The FGF family: biology, pathophysiology and therapyQ36933339
VEGF Trap induces antiglioma effect at different stages of diseaseQ37284357
ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedsideQ37312735
FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?Q37333639
Positive and negative modulation of angiogenesis by VEGFR1 ligandsQ37401612
Silencing or fueling metastasis with VEGF inhibitors: antiangiogenesis revisitedQ37403323
Intricacies of bevacizumab-induced toxicities and their managementQ37406599
Pathways mediating VEGF-independent tumor angiogenesisQ37652164
Lymphangiogenesis: Molecular mechanisms and future promiseQ37697245
BIBF 1120 for the treatment of non-small cell lung cancerQ37750755
Targeting the ANGPT-TIE2 pathway in malignancyQ37774852
Ramucirumab (IMC-1121B): Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2.Q37827451
Targeting the angiopoietin/Tie2 pathway: cutting tumor vessels with a double-edged sword?Q37970070
Anti-angiogenesis therapy in cancer: current challenges and future perspectivesQ37994504
Cediranib: a VEGF receptor tyrosine kinase inhibitorQ38029363
P433issue6
P921main subjectendotheliumQ111140
P304page(s)660-673
P577publication date2015-05-22
P1433published inOncologistQ2122327
P1476titleTargeting Angiogenesis in Cancer Therapy: Moving Beyond Vascular Endothelial Growth Factor
P478volume20

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cites work (P2860)
Q8877143386/90Y-Based Theranostics Targeting Angiogenesis in a Murine Breast Cancer Model
Q3379929799mTc-labeled bevacizumab for detecting atherosclerotic plaque linked to plaque neovascularization and monitoring antiangiogenic effects of atorvastatin treatment in ApoE-/- mice
Q41367937A systems medicine approach for finding target proteins affecting treatment outcomes in patients with non-Hodgkin lymphoma.
Q37189966Addressing the Symptoms or Fixing the Problem? Developing Countermeasures against Normal Tissue Radiation Injury.
Q92816090Advances of Zinc Signaling Studies in Prostate Cancer
Q90569887An Insight into the Angiogenic and Lymphatic Interplay in Pre-eclampsia Comorbid with HIV Infection
Q38631373An overview of tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer.
Q37416749Androgen receptor (AR) signaling promotes RCC progression via increased endothelial cell proliferation and recruitment by modulating AKT → NF-κB → CXCL5 signaling
Q39368829Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis.
Q96135356Angiogenesis in Breast Cancer Progression, Diagnosis, and Treatment
Q38763633Angiogenesis in NSCLC: is vessel co-option the trunk that sustains the branches?
Q41258130Anti-angiogenic agents for the treatment of solid tumors: Potential pathways, therapy and current strategies - A review.
Q92764365Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer
Q91940207Anti-metastasis traditional Chinese medicine monomer screening system based on perinucleolar compartment analysis in hepatocellular carcinoma cells
Q38744423Antiangiogenic Effects of Nerve Growth Factor Loop 4 Monomeric Dipeptide Mimetic
Q36334914Antiangiogenic effects of oridonin
Q42366549Antitumor immunity induced by VE-cadherin modified DC vaccine
Q94545744Association of angiogenesis and inflammation-related gene functional polymorphisms with early-stage breast cancer prognosis
Q36958382BRAF kinase inhibitor exerts anti-tumor activity against breast cancer cells via inhibition of FGFR2.
Q92126848Biological Functions and Molecular Mechanisms of Antibiotic Tigecycline in the Treatment of Cancers
Q27853358Biomarkers of evasive resistance predict disease progression in cancer patients treated with antiangiogenic therapies
Q58605561Body fatness, adipose tissue compartments and biomarkers of inflammation and angiogenesis in colorectal cancer: the ColoCare Study
Q36390700Bone marrow derived myeloid cells orchestrate antiangiogenic resistance in glioblastoma through coordinated molecular networks
Q98163452Both p53 codon 72 Arg/Arg and pro/Arg genotypes in glioblastoma multiforme are associated with a better prognosis in bevacizumab treatment
Q90446036C-type lectin family XIV members and angiogenesis
Q47313921Cancer Hallmarks Analytics Tool (CHAT): a text mining approach to organize and evaluate scientific literature on cancer
Q39991182Cervical cancer systemic inflammation score: a novel predictor of prognosis
Q90571077Chemoresistance of Cancer Cells: Requirements of Tumor Microenvironment-mimicking In Vitro Models in Anti-Cancer Drug Development
Q47627726Clinical implications of in silico mathematical modeling for glioblastoma: a critical review.
Q90737495Clinical significance of a pvrl 4 encoded gene Nectin-4 in metastasis and angiogenesis for tumor relapse
Q92945264Combination of Epigallocatechin-3-gallate and Silibinin: A Novel Approach for Targeting Both Tumor and Endothelial Cells
Q64064784Coptidis Rhizoma: a comprehensive review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
Q94471894Correlation of gene polymorphisms of vascular endothelial growth factor with grade and prognosis of lung cancer
Q52661758Crosstalk between VEGFR and other receptor tyrosine kinases for TKI therapy of metastatic renal cell carcinoma.
Q47176438Curcumin inhibits gastric cancer-derived mesenchymal stem cells mediated angiogenesis by regulating NF-κB/VEGF signaling
Q41103676Design, synthesis, and evaluation of VEGFR-targeted macromolecular MRI contrast agent based on biotin-avidin-specific binding
Q47597969Designing Fcabs: well-expressed and stable high affinity antigen-binding Fc fragments.
Q55031374Diminished oligomerization in the synthesis of new anti-angiogenic cyclic peptide using solution instead of solid-phase cyclization.
Q92863794Down-regulation of TGF-β, VEGF, and bFGF in vascular endothelial cells of chicken induced by a brittle star (Ophiocoma erinaceus) extract
Q37718673Dual roles of protein tyrosine phosphatase kappa in coordinating angiogenesis induced by pro-angiogenic factors.
Q38737411Effects of toceranib phosphate (Palladia) monotherapy on multidrug resistant lymphoma in dogs
Q47105124Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumor after failure with imatinib and sunitinib treatment: A meta-analysis
Q45124523Endostar in combination with postoperative adjuvant chemotherapy prolongs the disease free survival of stage IIIA NSCLC patients with high VEGF expression
Q26771513Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker
Q37637658Erlotinib for advanced hepatocellular carcinoma. A systematic review of phase II/III clinical trials
Q61798748Evaluation of Riboflavin Transporters as Targets for Drug Delivery and Theranostics
Q90581934Extracellular Vesicles (EVs) from Lung Adenocarcinoma Cells Promote Human Umbilical Vein Endothelial Cell (HUVEC) Angiogenesis through Yes Kinase-associated Protein (YAP) Transport
Q44643445Fibroblast Growth Factor Receptor 2 Signaling in Breast Cancer
Q91796711Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets
Q36772187Gamabufotalin, a major derivative of bufadienolide, inhibits VEGF-induced angiogenesis by suppressing VEGFR-2 signaling pathway.
Q52668325How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive.
Q37731561Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma
Q52665656Hypoxia-dependent mitochondrial fission regulates endothelial progenitor cell migration, invasion, and tube formation.
Q57041735Impaired tumor growth and angiogenesis in mice heterozygous for Vegfr2 (Flk1)
Q55019812In silico prediction of targets for anti-angiogenesis and their in vitro evaluation confirm the involvement of SOD3 in angiogenesis.
Q47118750Inhibition of STAT3/VEGF/CDK2 axis signaling is critically involved in the antiangiogenic and apoptotic effects of arsenic herbal mixture PROS in non-small lung cancer cells
Q91760986Inhibition of Sphingosine Phosphate Receptor 1 Signaling Enhances the Efficacy of VEGF Receptor Inhibition
Q48330378Isolation and screening of proangiogenic and antiangiogenic metabolites producing rare actinobacteria from soil.
Q58698138It Takes Two: Endothelial-Perivascular Cell Cross-Talk in Vascular Development and Disease
Q38743870KIF26B, a novel oncogene, promotes proliferation and metastasis by activating the VEGF pathway in gastric cancer
Q26773408Killing cancer with platycodin D through multiple mechanisms
Q54977595Lymphatics-associated genes are downregulated at transcription level in non-small cell lung cancer.
Q28073613Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment
Q37745389MiRNA199a-3p suppresses tumor growth, migration, invasion and angiogenesis in hepatocellular carcinoma by targeting VEGFA, VEGFR1, VEGFR2, HGF and MMP2.
Q42654040MicroRNA-16-5p overexpression suppresses proliferation and invasion as well as triggers apoptosis by targeting VEGFA expression in breast carcinoma
Q99632062Modulating barriers of tumor microenvironment through nanocarrier systems for improved cancer immunotherapy: a review of current status and future perspective
Q47998495Mouse models of neurodegenerative disease: preclinical imaging and neurovascular component.
Q47797389N-tert-butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe (BOC2) inhibits the angiogenic activity of heparin-binding growth factors
Q38772275Nanotherapy silencing the interleukin-8 gene produces regression of prostate cancer by inhibition of angiogenesis
Q57493127Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications
Q47221234New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness
Q49800025New insights into the regulatory role of microRNA in tumor angiogenesis and clinical implications
Q86756703Nintedanib and ovarian cancer: standardise surgery in trials?
Q51824301Nintedanib in ovarian cancer.
Q42516349Nintedanib treatment delays prostate dorsolateral lobe cancer progression in the TRAMP model: Contribution to the epithelial-stromal interaction balance
Q37003836Peptide-coated gold nanoparticles for modulation of angiogenesis in vivo
Q41329829Pharmacokinetics of calycopterin and xanthmicrol, two polymethoxylated hydroxyflavones with anti-angiogenic activities from Dracocephalum kotschyi Bioss
Q38753875Pharmacological Activities of Ruthenium Complexes Related to Their NO Scavenging Properties
Q50419857Potential lymphangiogenesis therapies: Learning from current antiangiogenesis therapies-A review.
Q47326758Potentiating angiogenesis arrest in vivo via laser irradiation of peptide functionalised gold nanoparticles.
Q92787614Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models
Q33897971Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue
Q91584750Prognostic genes of melanoma identified by weighted gene co-expression network analysis and drug repositioning using a network-based method
Q45852322Prohibitin, relocated to the front ends, can control the migration directionality of colorectal cancer cells
Q38829362RNAi-mediated downregulation of oral cancer overexpressed 1 (ORAOV1) inhibits vascular endothelial cell proliferation, migration, invasion, and tube formation
Q64103672Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy
Q58607138Receptor Tyrosine Kinase-Targeted Cancer Therapy
Q90094407Reimaging biological barriers affecting distribution and extravasation of PEG/peptide- modified liposomes in xenograft SMMC7721 tumor
Q126338271Retracted Article: Panax notoginseng saponins regulate VEGF to suppress esophageal squamous cell carcinoma progression via DVL3-mediated Wnt/β-catenin signaling
Q33732986Revisiting the hallmarks of cancer
Q47150792Role of VEGFA gene polymorphisms in colorectal cancer patients who treated with bevacizumab
Q57169852Role of hypoxia-induced exosomes in tumor biology
Q52675438Role of the Nervous System in Tumor Angiogenesis.
Q49866596Roles of toll-like receptors: From inflammation to lung cancer progression
Q50107409SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models
Q58750993SOX5 induces lung adenocarcinoma angiogenesis by inducing the expression of VEGF through STAT3 signaling
Q26801785Sequencing Overview of Ewing Sarcoma: A Journey across Genomic, Epigenomic and Transcriptomic Landscapes
Q38767147Short peptides interfering with signaling pathways as new therapeutic tools for cancer treatment
Q89881990Silencing of HOXB9 suppresses cellular proliferation, angiogenesis, migration and invasion of prostate cancer cells
Q99614305Surufatinib in advanced pancreatic neuroendocrine tumours (SANET-p): a randomised, double-blind, placebo-controlled, phase 3 study
Q57055294Targeted and Immune-based Therapies for Hepatocellular Carcinoma
Q45874034Targeted delivery of miR-199a-3p using self-assembled dipeptide nanoparticles efficiently reduces hepatocellular carcinoma
Q26801841The Contribution of Angiogenesis to the Process of Metastasis
Q64962531The Efficacy and Safety of Apatinib Treatment for Patients with Unresectable or Relapsed Liver Cancer: a retrospective study.
Q50864970The Precision of Hepatic Arterial Infusion Scintigraphy as a Quantitative Biomarker of Tumor Microvasculature.
Q39120772The Role of PDGFs and PDGFRs in Colorectal Cancer.
Q47553825The Role of Wnt Signalling in Angiogenesis
Q91742138The Role of YAP and TAZ in Angiogenesis and Vascular Mimicry
Q55437410The coordinated effects of Apatinib and Tripterine on the proliferation, invasiveness and apoptosis of human hepatoma Hep3B cells.
Q61803634The effect of cycling hypoxia on MCF-7 cancer stem cells and the impact of their microenvironment on angiogenesis using human umbilical vein endothelial cells (HUVECs) as a model
Q55518573The β3-integrin endothelial adhesome regulates microtubule-dependent cell migration.
Q64055886Tumor Neovascularization and Developments in Therapeutics
Q39393740Tumor angiogenesis revisited: Regulators and clinical implications.
Q64913955Ultrasonic Cavitation Ameliorates Antitumor Efficacy of Residual Cancer After Incomplete Radiofrequency Ablation in Rabbit VX2 Liver Tumor Model.
Q28073155Unraveling the Anticancer Effect of Curcumin and Resveratrol
Q47918409VEGF as a potential target in lung cancer
Q92012918Vascular PPARβ/δ Promotes Tumor Angiogenesis and Progression
Q52655088Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo.
Q92308319Yu Ping Feng San Exert Anti-Angiogenesis Effects through the Inhibition of TSLP-STAT3 Signaling Pathways in Hepatocellular Carcinoma
Q35996844α-Mangostin, a Natural Agent, Enhances the Response of NRAS Mutant Melanoma to Retinoic Acid

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