Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury

scientific article published on 16 October 2006

Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SJ.BJP.0706922
P932PMC publication ID2014640
P698PubMed publication ID17043673
P5875ResearchGate publication ID6751296

P2093author name stringS H Lee
J H Ahn
M J Kim
M-Y Kim
E J Baik
Y-S Jung
I S Yoon
C-H Moon
P2860cites workDiazoxide, an inhibitor of succinate oxidationQ68628261
Mitochondrial ATP-sensitive K+ channels modulate cardiac mitochondrial functionQ77551484
Role of protein kinase C as a cellular mediator of ischemic preconditioning: a critical reviewQ77755911
Role of protein kinase C in mitochondrial KATP channel-mediated protection against Ca2+ overload injury in rat myocardiumQ77807883
Mitochondrial PKCepsilon and MAPK form signaling modules in the murine heart: enhanced mitochondrial PKCepsilon-MAPK interactions and differential MAPK activation in PKCepsilon-induced cardioprotectionQ28205800
Mitochondrial calcium transport: physiological and pathological relevanceQ28247285
Localization of protein kinase C isozymes in cardiac myocytesQ28259191
Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection?Q28274707
PKC-epsilon is upstream and PKC-alpha is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardiumQ28275661
Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signalingQ35058606
Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels.Q35194249
KR-32570, a novel Na+/H+ exchanger-1 inhibitor, attenuates hypoxia-induced cell death through inhibition of intracellular Ca2+ overload and mitochondrial death pathway in H9c2 cellsQ38512314
KR-31378, a novel benzopyran analog, attenuates hypoxia-induced cell death via mitochondrial KATP channel and protein kinase C-epsilon in heart-derived H9c2 cellsQ38515747
Isoform-specific induction of PKC-epsilon by high glucose protects heart-derived H9c2 cells against hypoxic injuryQ38519666
KR-31466, a benzopyranylindol analog, attenuates hypoxic injury through mitochondrial K(ATP) channel and protein kinase C activation in heart-derived H9c2 cellsQ38520029
Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heartQ41655457
Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic propertiesQ42036561
Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondriaQ42211774
PKC epsilon -mediated ERK1/2 activation involved in radiation-induced cell death in NIH3T3 cellsQ42805420
Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit heartsQ43512698
Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxideQ43660504
Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotectionQ43794479
Preconditioning blocks cardiocyte apoptosis: role of K(ATP) channels and PKC-epsilonQ43917353
Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioningQ44027057
Differential effects of anesthetics on mitochondrial K(ATP) channel activity and cardiomyocyte protectionQ44072496
Differential actions of cardioprotective agents on the mitochondrial death pathwayQ44306737
Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protectionQ44832208
Modulation of mitochondrial calcium management attenuates hepatic warm ischemia-reperfusion injuryQ46509153
Protein kinase G transmits the cardioprotective signal from cytosol to mitochondriaQ46613392
Modulation of mitochondrial ATP-dependent K+ channels by protein kinase C.Q47817361
Selective loading of Rhod 2 into mitochondria shows mitochondrial Ca2+ transients during the contractile cycle in adult rabbit cardiac myocytes.Q53858985
Activation of mitochondrial ATP-sensitive K(+) channel for cardiac protection against ischemic injury is dependent on protein kinase C activity.Q53923660
P433issue8
P407language of work or nameEnglishQ1860
P921main subjecthypoxiaQ105688
P304page(s)1059-1070
P577publication date2006-10-16
P1433published inBritish Journal of PharmacologyQ919631
P1476titleDiazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury
P478volume149

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cites work (P2860)
Q26744723ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force
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Q34415652Effects of propofol on ischemia-induced ventricular arrhythmias and mitochondrial ATP-sensitive potassium channels
Q38488490Gadd45beta is a novel mediator of cardiomyocyte apoptosis induced by ischaemia/hypoxia
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Q38496407Methanolic extract of onion (Allium cepa) attenuates ischemia/hypoxia-induced apoptosis in cardiomyocytes via antioxidant effect
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