Endothelin Receptor Antagonists: New Hope for Renal Protection?

scientific article published on July 2015

Endothelin Receptor Antagonists: New Hope for Renal Protection? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1026849723
P356DOI10.1007/S11906-015-0568-7
P698PubMed publication ID26068660

P50authorSheldon W. TobeQ58091532
P2093author name stringDonald E Kohan
Ranjit Singarayer
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Clinical trials with endothelin receptor antagonists: what went wrong and where can we improve?Q34660839
Addition of atrasentan to renin-angiotensin system blockade reduces albuminuria in diabetic nephropathyQ34726905
New therapeutics that antagonize endothelin: promises and frustrationsQ35013988
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Endothelin receptors, renal effects and blood pressure.Q38301944
The endothelin receptor antagonist bosentan improves peripheral endothelial function in patients with type 2 diabetes mellitus and microalbuminuria: a randomised trial.Q40013771
Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cellsQ41086982
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Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats. Evidence for a role of endothelin in vascular hypertrophyQ42283633
Constitutive expression of endothelin gene in cultured human mesangial cells and its modulation by transforming growth factor-beta, thrombin, and a thromboxane A2 analogue.Q42466255
Endothelin production in cultured mesangial cells of spontaneously hypertensive ratsQ42486301
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ETA and ETB receptors differentially modulate afferent and efferent arteriolar responses to endothelinQ43054826
A selective endothelin-receptor antagonist to reduce blood pressure in patients with treatment-resistant hypertension: a randomised, double-blind, placebo-controlled trialQ43277549
Do results of the ENABLE (Endothelin Antagonist Bosentan for Lowering Cardiac Events in Heart Failure) study spell the end for non-selective endothelin antagonism in heart failure?Q44123593
Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trialQ44315403
Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention.Q44328081
Regulation of endothelin-1 production in cultured rat mesangial cellsQ44484903
Blood pressure-independent reduction in proteinuria and arterial stiffness after acute endothelin-a receptor antagonism in chronic kidney disease.Q45977797
Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitusQ46696790
An overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin®), a potent endothelin receptor antagonist developed for pulmonary arterial hypertensionQ47644192
Endothelin-induced endocytosis of cell surface ETA receptors. Endothelin remains intact and bound to the ETA receptorQ49165131
Distinct cardiac and renal effects of ETA receptor antagonist and ACE inhibitor in experimental type 2 diabetes.Q50789643
Endothelin-receptor antagonists for diabetic nephropathy: A meta-analysis.Q51000648
Clinical efficacy of the selective endothelin A receptor antagonist, atrasentan, in patients with diabetes and chronic kidney disease (CKD).Q53387958
Haemodynamic and renal effects of endothelin receptor antagonism in patients with chronic kidney diseaseQ56987897
Influence of Cardiovascular Damage and Residual Renal Function on Plasma Endothelin in Chronic Renal FailureQ58951354
Canadian Society of Nephrology Commentary on the 2012 KDIGO Clinical Practice Guideline for the Management of Blood Pressure in CKDQ59600909
Comparative sensitivities of isolated rat renal arterioles to endothelinQ67586610
Enhanced secretion of endothelin-1 by elevated glucose levels from cultured bovine aortic endothelial cellsQ68340174
Renal microvascular effects of endothelinQ68534119
Direct visualization of effects of endothelin on the renal microvasculatureQ68928651
Localization of endothelin ETA and ETB receptor-mediated constriction in the renal microcirculation of ratsQ71851592
Cardiac natriuretic peptides inhibit cyclosporine-induced production of endothelin in cultured rat mesangial cellsQ72618785
Endothelin receptor subtype B mediates autoinduction of endothelin-1 in rat mesangial cellsQ72645728
Effects of chronic ETA-receptor blockade in angiotensin II-induced hypertensionQ73086588
ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertensionQ74132786
Safety and efficacy of the specific endothelin-A receptor antagonist ZD4054 in patients with hormone-resistant prostate cancer and bone metastases who were pain free or mildly symptomatic: a double-blind, placebo-controlled, randomised, phase 2 triaQ82766552
Selective endothelin-A receptor antagonism reduces proteinuria, blood pressure, and arterial stiffness in chronic proteinuric kidney diseaseQ83489879
P433issue7
P304page(s)57
P577publication date2015-07-01
P1433published inCurrent Hypertension ReportsQ15746362
P1476titleEndothelin Receptor Antagonists: New Hope for Renal Protection?
P478volume17

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cites work (P2860)
Q38806647Atrasentan for the treatment of diabetic nephropathy.
Q37391757Endothelin-1 Immunoreactivity and its Association with Intramedullary Hemorrhage and Myelomalacia in Naturally Occurring Disk Extrusion in Dogs

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