N3-methyl-mafosfamide as a chemically stable, alternative prodrug of mafosfamide

scientific article published on July 1998

N3-methyl-mafosfamide as a chemically stable, alternative prodrug of mafosfamide is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0960-894X(98)00287-X
P698PubMed publication ID9873412

P2093author name stringKwon CH
Moon KY
P2860cites workPreclinical evaluation of toxicity and therapeutic efficacy of a stabilized cytostatic metabolite of cyclophosphamide (ASTA Z 7557, INN mafosfamide)Q70589453
Experimental toxicology of ASTA Z 7557 (INN mafosfamide)Q70589457
Comparative effects of ASTA Z 7557 (INN mafosfamide) and cyclophosphamide on hematopoiesis in miceQ70589461
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Cyclophosphamide cystitis—Identification of acrolein as the causative agentQ28327805
Phase-I study of mafosfamide-cyclohexylamine (ASTA-Z-7557, NSC 345 842) and limited phase-I data on mafosfamide-lysineQ36500339
Chemical characterization of ASTA Z 7557 (INN mafosfamide, CIS-4-sulfoethylthio-cyclophosphamide), a stable derivative of 4-hydroxy-cyclophosphamideQ36606835
Chemically stable N-methyl-4-(alkylthio)cyclophosphamide derivatives as prodrugs of 4-hydroxycyclophosphamideQ38531856
Chemically stable, lipophilic prodrugs of phosphoramide mustard as potential anticancer agentsQ38534100
Metabolism of oxazaphosphorinesQ39649226
Prevention of cyclophosphamide-induced carcinogenesis in the urinary bladder of rats by administration of mesnaQ42248658
Cocarcinogenic and tumor-promoting capabilities of anthralinQ42805466
Influence of mesna and cysteine on the systemic toxicity and therapeutic efficacy of activated cyclophosphamideQ44054408
Effects of N-substitution on the activation mechanisms of 4-hydroxycyclophosphamide analogues.Q54107375
Antineoplastic activity of ASTA Z 7557 (NSC-345842, INN mafosfamide) on transplantable murine tumors.Q54483151
Isolation and mass spectral identification of blood metabolities of cyclophosphamide: Evidence for phosphoramide mustard as the biologically active metaboliteQ66931110
Activation mechanisms of mafosfamide and the role of thiols in cyclophosphamide metabolismQ69729345
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Comparative in vitro cytotoxicity of cyclophosphamide, its major active metabolites and the new oxazaphosphorine ASTA Z 7557 (INN mafosfamide)Q70589430
A comparative study of therapeutic activity, myelotoxicity and DNA damage in the bone marrow of mice after cyclophosphamide and ASTA Z 7557 (INN mafosfamide)Q70589449
P433issue13
P407language of work or nameEnglishQ1860
P304page(s)1673-1678
P577publication date1998-07-01
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleN3-methyl-mafosfamide as a chemically stable, alternative prodrug of mafosfamide
P478volume8

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