Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer

scientific article published on 25 June 2015

Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3389/FONC.2015.00138
P932PMC publication ID4479729
P698PubMed publication ID26161361
P5875ResearchGate publication ID279986736

P50authorStephen A WhelanQ58326849
Wagner B DiasQ58326856
P2093author name stringIsadora A Oliveira
Adriane Regina Todeschini
Andréia Vasconcelos-Dos-Santos
Miguel Clodomiro Lucena
Natalia Rodrigues Mantuano
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A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferasesQ22008686
Cloning and expression of a proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I. A seventh member of the human beta4-galactosyltransferase gene familyQ22010511
Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigensQ22010719
Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase familyQ24290427
Phosphofructokinase 1 glycosylation regulates cell growth and metabolismQ24297510
Engagement of I-branching {beta}-1, 6-N-acetylglucosaminyltransferase 2 in breast cancer metastasis and TGF-{beta} signalingQ24313363
A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3Q24314565
Expression cloning of cDNA encoding a human beta-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesisQ24314988
The expanding beta 4-galactosyltransferase gene family: messages from the databanksQ24318549
Expression of the developmental I antigen by a cloned human cDNA encoding a member of a beta-1,6-N-acetylglucosaminyltransferase gene familyQ24322660
A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancerQ24336874
Structure of human O-GlcNAc transferase and its complex with a peptide substrateQ24337218
Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytesQ24648559
Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferaseQ24672069
Haploinsufficiency of C2GnT-I glycosyltransferase renders T lymphoma cells resistant to cell deathQ24685820
N-glycans in cell survival and death: cross-talk between glycosyltransferasesQ27027708
Crystal structures of the bovine beta 4galactosyltransferase catalytic domain and its complex with uridine diphosphogalactoseQ27618915
Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding siteQ27639089
Structural insights into mechanism and specificity of O-GlcNAc transferaseQ27652304
O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysisQ27674743
A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferaseQ27675565
Specificity of Processing  -Glucosidase I Is Guided by the Substrate Conformation: CRYSTALLOGRAPHIC AND IN SILICO STUDIESQ27677099
Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitorsQ27680651
On the Origin of Cancer CellsQ27861025
Prognostic significance of UDP‐N‐acetyl‐α‐D‐galactosamine:polypeptide N‐acetylgalactosaminyltransferase‐3 (GalNAc‐T3) expression in patients with gastric carcinomaQ28199057
Expression of uridine diphosphate N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase 3 in adenocarcinoma of the pancreasQ28209189
Mucins in cancer: protection and control of the cell surfaceQ28235006
Expression of core 2 beta1,6-N-acetylglucosaminyltransferase facilitates prostate cancer progressionQ28254372
Glycolysis inhibition for anticancer treatmentQ28256222
Purification of two glycoproteins expressing beta 1-6 branched Asn-linked oligosaccharides from metastatic tumour cellsQ28275660
Siglecs and their roles in the immune systemQ28294469
Molecular cloning and expression of a novel beta-1, 6-N-acetylglucosaminyltransferase that forms core 2, core 4, and I branchesQ28294981
Cycling of O-linked beta-N-acetylglucosamine on nucleocytoplasmic proteinsQ28299550
Five specificity patterns of (1----3)-alpha-L-fucosyltransferase activity defined by use of synthetic oligosaccharide acceptors. Differential expression of the enzymes during human embryonic development and in adult tissuesQ28316034
A bisubstrate analog inhibitor for alpha(1----2)-fucosyltransferaseQ28342980
Differential expression of the Lewis Y antigen defined by monoclonal antibody C14/1/46/10 in colonic polypsQ69636906
Suppressed expression of blood group B antigen and blood group galactosyltransferase in a preleukemic subjectQ69963428
Effect of inhibitors of glycosylation and carbohydrate processing on invasion of malignant mouse MO4 cells in organ cultureQ69976955
Glycoprotein modifications of sarcoma L-1 tumor cells by tunicamycin, swainsonine, bromoconduritol or 1-desoxynojirimycin treatment inhibits their metastatic lung colonization in Balb/c-miceQ70049884
Blood group-related antigens in human germ cell tumorsQ70200256
Activity of the human blood group ABO, Se, H, Le, and X gene-encoded glycosyltransferases in normal and malignant bladder urotheliumQ70394893
Castanospermine, a tetrahydroxylated alkaloid that inhibits beta-glucosidase and beta-glucocerebrosidaseQ70429718
Inhibition of N-linked oligosaccharide processing in tumor cells is associated with enhanced tissue inhibitor of metalloproteinases (TIMP) gene expressionQ70568015
Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancerQ70840050
Involvement of N-acetyl-lactosamine-containing sugar structures in the liver metastasis of mouse colon carcinoma (colon 26) cellsQ71675210
Benzyl-N-acetyl-alpha-D-galactosaminide inhibits the sialylation and the secretion of mucins by a mucin secreting HT-29 cell subpopulationQ71762333
Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endotheliumQ72067065
Expression of Sialyl Lewisa as a new prognostic factor for patients with advanced colorectal carcinomaQ72112395
Up-regulation of the oligosaccharide sialyl LewisX: a new prognostic parameter in metastatic prostate cancerQ72187133
Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical studyQ72226978
Progress in pharmacology of cerebral ischemiaQ72483455
Processing O-glycan core 1, Gal beta 1-3GalNAc alpha-R. Specificities of core 2, UDP-GlcNAc: Gal beta 1-3 GalNAc-R(GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase and CMP-sialic acid: Gal beta 1-3GalNAc-R alpha 3-sialyltransferaseQ72750319
Induction of suppressor T cells by neuraminic acid derivativesQ72771528
A search for pyrophosphate mimics for the development of substrates and inhibitors of glycosyltransferasesQ73354887
Synthesis and biological evaluation of new UDP-GalNAc analogues for the study of polypeptide-alpha-GalNAc-transferasesQ73400279
Endothelial and epithelial expression of sialyl Lewis(x) and sialyl Lewis(a) in lesions of breast carcinomaQ73507939
Characterization of the N-oligosaccharides attached to the atypical Asn-X-Cys sequence of recombinant human epidermal growth factor receptorQ73580767
Thomsen-Friedenreich antigen presents as a prognostic factor in colorectal carcinoma: A clinicopathologic study of 264 patientsQ73595096
Overexpression of sialyltransferase CMP-sialic acid:Galbeta1,3GalNAc-R alpha6-Sialyltransferase is related to poor patient survival in human colorectal carcinomasQ73963471
The C-disaccharide alpha-C(1-->3)-mannopyranoside of N-acetylgalactosamine is an inhibitor of glycohydrolases and of human alpha-1,3-fucosyltransferase VI. Its epimer alpha-(1-->3)-mannopyranoside of N-acetyltalosamine is notQ73983003
Synthesis of the First Tricomponent Bisubstrate Analogue That Exhibits Potent Inhibition against GlcNAc:beta-1,4-GalactosyltransferaseQ74835614
Overexpression of alpha1-6 fucosyltransferase in hepatoma cells suppresses intrahepatic metastasis after splenic injection in athymic miceQ77415654
Acceptor substrate-based selective inhibition of galactosyltransferasesQ77749861
Panosialins, inhibitors of an alpha1,3-fucosyltransferase Fuc-TVII, suppress the expression of selectin ligands on U937 cellsQ77937139
UDP-Gal: GlcNAc-R beta1,4-galactosyltransferase--a target enzyme for drug design. Acceptor specificity and inhibition of the enzymeQ79151523
Non-isosteric C-glycosyl analogues of natural nucleotide diphosphate sugars as glycosyltransferase inhibitorsQ79914266
Stachybotrydial, a potent inhibitor of fucosyltransferase and sialyltransferaseQ81729837
Different levels of sialyl-Tn antigen expressed on MUC16 in patients with endometriosis and ovarian cancerQ83517332
N-glycan biosynthesis inhibitors induce in vitro anticancer activity in colorectal cancer cellsQ84061409
Identification and assessment of new biomarkers for colorectal cancer with serum N-glycan profilingQ84792401
Clinical utility of high-throughput glycome analysis in patients with pancreatic cancerQ85888507
Immunohistochemical expression of core 2 β1,6-N-acetylglucosaminyl transferase 1 (C2GnT1) in endometrioid-type endometrial carcinoma: a novel potential prognostic factorQ86655191
Inhibition of sialyltransferases of murine lymphocytes by disaccharide nucleosidesQ93594207
Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeatsQ28508776
Cell surface and Golgi pools of beta-1,4-galactosyltransferase are differentially regulated during embryonal carcinoma cell differentiationQ28511313
Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brainQ28581590
The biology of cancer: metabolic reprogramming fuels cell growth and proliferationQ29547301
Plasma membrane domain organization regulates EGFR signaling in tumor cellsQ30480578
Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification.Q30490721
Hyper-O-GlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cellsQ30540051
Human fucosyltransferase 6 enables prostate cancer metastasis to boneQ30559315
The cancer glycocalyx mechanically primes integrin-mediated growth and survivalQ30656235
Selective inhibition of beta-1,4- and alpha-1,3-galactosyltransferases: donor sugar-nucleotide based approachQ30675849
Synthesis of novel donor mimetics of UDP-Gal, UDP-GlcNAc, and UDP-GalNAc as potential transferase inhibitorsQ30870958
Small molecule inhibitors of mucin-type O-linked glycosylation from a uridine-based libraryQ31056671
Cell surface-specific N-glycan profiling in breast cancerQ31137153
The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.Q31705505
Molecular cloning and functional expression of a fifth-type alpha 2,3-sialyltransferase (mST3Gal V: GM3 synthase).Q31942000
Purification and characterization of UDP-GlcNAc:Galbeta1-4GlcNAcbeta1-3*Galbeta1-4Glc(NAc)-R(GlcNAc to *Gal) beta1,6N-acetylglucosaminyltransferase from hog small intestineQ32003154
Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylationQ32058522
The chicken genome contains two functional nonallelic beta1,4-galactosyltransferase genes. Chromosomal assignment to syntenic regions tracks fate of the two gene lineages in the human genome.Q32184176
Phase I trial of the anti-Lewis Y drug immunoconjugate BR96-doxorubicin in patients with lewis Y-expressing epithelial tumorsQ33180441
Rational design, synthesis, and characterization of novel inhibitors for human beta1,4-galactosyltransferaseQ33223341
Tumor beta-1,4-galactosyltransferase IV overexpression is closely associated with colorectal cancer metastasis and poor prognosisQ33229798
N-Acetylgalactosaminyltransferase-14 as a potential biomarker for breast cancer by immunohistochemistryQ33548177
The endoplasmic reticulum chaperone Cosmc directly promotes in vitro folding of T-synthaseQ33593911
O-GlcNAcylation: The Sweet Side of the CancerQ33701447
Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancerQ33703870
Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancerQ33783766
Oligosaccharyltransferase: a complex multisubunit enzyme of the endoplasmic reticulumQ33797976
Trypanosoma cruzi subverts host cell sialylation and may compromise antigen-specific CD8+ T cell responsesQ33809905
Tissue distribution of histo-blood group antigensQ33852459
Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residueQ33885664
alpha1,6fucosyltransferase is highly and specifically expressed in human ovarian serous adenocarcinomasQ33926327
Neuronal expression of Mgat1 rescues the shortened life span of Drosophila Mgat11 null mutants and increases life spanQ34006812
Glycosylation defining cancer malignancy: new wine in an old bottleQ34074081
alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivoQ34098948
Serum N-glycan alteration associated with renal cell carcinoma detected by high throughput glycan analysisQ35021015
The identification and characterization of novel N-glycan-based biomarkers in gastric cancer.Q35023434
Polypeptide N-acetylgalactosaminyltransferase 6 expression in pancreatic cancer is an independent prognostic factor indicating better overall survivalQ35034722
gem-Diamine 1-N-iminosugars and related iminosugars, candidate of therapeutic agents for tumor metastasisQ35061492
Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycinQ35309992
Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition processQ35470512
Biosynthesis and Function of ß 1,6 Branched Mucin-Type GlycansQ35554091
Tumor-Associated Carbohydrate Antigens Defining Tumor Malignancy: Basis for Development of Anti-Cancer VaccinesQ35554103
Oligosaccharide modification by swainsonine treatment inhibits pulmonary colonization by B16-F10 murine melanoma cellsQ35595004
Enhancement of metastatic ability by ectopic expression of ST6GalNAcI on a gastric cancer cell line in a mouse model.Q35745593
O-GlcNAc signalling: implications for cancer cell biologyQ35793071
Cross talk between O-GlcNAcylation and phosphorylation: roles in signaling, transcription, and chronic diseaseQ35804446
Gene expression of O-GlcNAc cycling enzymes in human breast cancersQ35809895
Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasisQ35879559
MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7.Q35922278
Tight complex formation between Cosmc chaperone and its specific client non-native T-synthase leads to enzyme activity and client-driven dissociationQ35939823
O-GlcNAcylation of kinasesQ36070732
Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viabilityQ36233025
Galectin-3 protein regulates mobility of N-cadherin and GM1 ganglioside at cell-cell junctions of mammary carcinoma cellsQ36294909
Three-dimensional structures of carbohydrate determinants of Lewis system antigens: implications for effective antibody targeting of cancerQ36304930
Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigenQ36436153
Glycolysis inhibitor screening identifies the bis-geranylacylphloroglucinol protonophore moronone from Moronobea coccinea.Q36494623
Fucosyltransferase 8 as a functional regulator of nonsmall cell lung cancerQ36535243
The mTOR inhibitor AZD8055 inhibits proliferation and glycolysis in cervical cancer cellsQ36611732
Overexpression of alpha(1,3)-fucosyltransferase VII is sufficient for the acquisition of lung colonization phenotype in human lung adenocarcinoma HAL-24Luc cellsQ36618060
UDP-Gal: betaGlcNAc beta1, 3-galactosyltransferase, polypeptide 3 (GALT3) is a tumour antigen recognised by HLA-A2-restricted cytotoxic T lymphocytes from patients with brain tumourQ36624402
Suppression of FUT1 attenuates cell proliferation in the HER2-overexpressing cancer cell line NCI-N87Q36642333
Development of orally active inhibitors of protein and cellular fucosylationQ36747458
The potential importance of swainsonine in therapy for cancers and immunologyQ36839125
Carbohydrate antigen sialyl Lewis a--its pathophysiological significance and induction mechanism in cancer progressionQ36924223
miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.Q36926211
Galectin-3- and phospho-caveolin-1-dependent outside-in integrin signaling mediates the EGF motogenic response in mammary cancer cellsQ36961108
Inhibition of N-linked glycosylation disrupts receptor tyrosine kinase signaling in tumor cellsQ36967036
O-GlcNAc modification in diabetes and Alzheimer's diseaseQ36973321
The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serumQ39879986
Role of E-cadherin N-glycosylation profile in a mammary tumor modelQ39892493
Enhanced expression of beta 3-galactosyltransferase 5 activity is sufficient to induce in vivo synthesis of extended type 1 chains on lactosylceramides of selected human colonic carcinoma cell lines.Q39896654
O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins.Q39931631
Human tumor antigens Tn and sialyl Tn arise from mutations in CosmcQ40002603
Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesisQ40023034
Inhibitors of the Biosynthesis and Processing of N-Linked OligosaccharideQ40116930
Complex N-glycan number and degree of branching cooperate to regulate cell proliferation and differentiation.Q40147884
A mutant chaperone converts a wild-type protein into a tumor-specific antigenQ40220542
Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.Q40233254
N-acetylglucosaminyltransferase III antagonizes the effect of N-acetylglucosaminyltransferase V on alpha3beta1 integrin-mediated cell migrationQ40238492
beta1,4-N-Acetylglucosaminyltransferase III potentiates beta1 integrin-mediated neuritogenesis induced by serum deprivation in Neuro2a cellsQ40306035
Soyasaponin I decreases the expression of alpha2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cellsQ40326598
Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity.Q40401752
Pilot study of a heptavalent vaccine-keyhole limpet hemocyanin conjugate plus QS21 in patients with epithelial ovarian, fallopian tube, or peritoneal cancerQ40444431
Stable expression of sialyl-Tn antigen in T47-D cells induces a decrease of cell adhesion and an increase of cell migration.Q40446171
Farnesyltransferase inhibitor R115777 (Zarnestra, Tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.Q40455268
Soyasaponin-I-modified invasive behavior of cancer by changing cell surface sialic acids.Q40468532
Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-12 in gastric and colonic cancer cell lines and in human colorectal cancer.Q40489058
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigenQ40507967
Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis.Q40508811
Synthesis of N-acetyllactosamine derivatives with variation in the aglycon moiety for the study of inhibition of sialyl Lewis x expressionQ40636020
Role of oligomannosidic N-glycans in the proliferation, adhesion and signalling of C6 glioblastoma cellsQ40645340
Immunization of ovarian cancer patients with a synthetic Lewis(y)-protein conjugate vaccine: a phase 1 trialQ40872664
The level of cell surface beta1,4-galactosyltransferase I influences the invasive potential of murine melanoma cells.Q40940802
Increase of rat colon carcinoma cells tumorigenicity by alpha(1-2) fucosyltransferase gene transfectionQ41122410
Suppression of sialyl Lewis X expression and E-selectin-mediated cell adhesion in cultured human lymphoid cells by transfection of antisense cDNA of an alpha1-->3 fucosyltransferase (Fuc-T VII).Q41145801
Biosynthesis of O-glycans in leukocytes from normal donors and from patients with leukemia: increase in O-glycan core 2 UDP-GlcNAc:Gal beta 3 GalNAc alpha-R (GlcNAc to GalNAc) beta(1-6)-N-acetylglucosaminyltransferase in leukemic cells.Q41178692
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistanceQ41179543
Metabolic inhibition of sialyl-Lewis X biosynthesis by 5-thiofucose remodels the cell surface and impairs selectin-mediated cell adhesion.Q41461652
O-glycan biosynthesis in human colorectal adenoma cells during progression to cancerQ41464494
Functional role of N-glycosylation in alpha 5 beta 1 integrin receptor. De-N-glycosylation induces dissociation or altered association of alpha 5 and beta 1 subunits and concomitant loss of fibronectin binding activity.Q41473286
Perspectives on the significance of altered glycosylation of glycoproteins in cancerQ41594921
Carbohydrate-mediated cell adhesion involved in hematogenous metastasis of cancer.Q41594926
Increased UDP-GlcNAc:Gal beta 1-3GaLNAc-R (GlcNAc to GaLNAc) beta-1, 6-N-acetylglucosaminyltransferase activity in metastatic murine tumor cell lines. Control of polylactosamine synthesisQ41699139
Synthesis of glycopyranosylphosphonate analogues of certain natural nucleoside diphosphate sugars as potential inhibitors of glycosyltransferasesQ42216218
Synthesis of certain nucleoside methylenediphosphonate sugars as potential inhibitors of glycosyltransferasesQ42216220
Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycomeQ42321222
Importance of E‐selectin (ELAM‐1) and sialyl lewisa in the adhesion of pancreatic carcinoma cells to acttvated endotheliumQ42483494
Lewis Y antigen as detected by the monoclonal antibody BR96 is expressed strongly in prostatic adenocarcinomaQ42484753
Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization.Q42728392
Cytochemical staining for beta 1,6 branching of asparagine-linked oligosaccharides in variants of metastatic human colon carcinoma cellsQ42753998
GLUT1 expression in malignant tumors and its use as an immunodiagnostic marker.Q42787448
Core fucosylation and alpha2-3 sialylation in serum N-glycome is significantly increased in prostate cancer comparing to benign prostate hyperplasia.Q43547830
Selective inhibition of glycosyltransferases by bivalent imidazolium saltsQ43581055
Soyasaponin I, a potent and specific sialyltransferase inhibitorQ43631707
Heterologous over-expression of alpha-1,6-fucosyltransferase from Rhizobium sp.: application to the synthesis of the trisaccharide beta-D-GlcNAc(1-->4)-[alpha-L-Fuc-(1-->6)]-D-GLcNAc, study of the acceptor specificity and evaluation of polyhydroxylaQ43669120
Over-expression of beta-1,4-galactosyltransferase I, II, and V in human astrocytomaQ43704811
STn and prognosis in breast cancer.Q43807787
An inhibitor of the human UDP-GlcNAc 4-epimerase identified from a uridine-based library: a strategy to inhibit O-linked glycosylationQ43884212
Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.Q44258575
Clinical and prognostic implications of β1, 6-N-acetylglucosaminyltransferase V in patients with gastric cancerQ44788875
Inhibition of fucosyltransferase VII by gallic acid and its derivativesQ44842720
Differences in prognosis of colorectal cancer patients based on the expression of sialyl Lewisa, sialyl Lewisx and sialyl Tn antigens in serum and tumor tissue.Q45031048
Asymmetric synthesis and affinity of potent sialyltransferase inhibitors based on transition-state analogues.Q45108458
C1GALT1 enhances proliferation of hepatocellular carcinoma cells via modulating MET glycosylation and dimerization.Q45158681
Prognostic influence of loss of blood group A antigen expression in pathologic stage I non-small-cell lung cancer.Q45231458
Expression of histo-blood-group-A/B-gene-defined glycosyltransferases in normal and malignant epithelia: correlation with A/B-carbohydrate expressionQ45767094
MDA-MB-435 human breast carcinoma cell homo- and heterotypic adhesion under flow conditions is mediated in part by Thomsen-Friedenreich antigen-galectin-3 interactions.Q45984505
Endothelial-selectin ligands sialyl Lewis(x) and sialyl Lewis(a) are differentiation antigens immunogenic in human melanoma.Q45997022
Bidirectional N-acetylglucosamine transfer mediated by beta-1,4-N-acetylglucosaminyltransferase III.Q46190757
Inhibition of mucin glycosylation by aryl-N-acetyl-alpha-galactosaminides in human colon cancer cells.Q46374429
Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas.Q37040588
Exploring the glycosylation of serum CA125.Q37139074
N-Glycans in cancer progressionQ37243167
Breast cancer humoral immune response: involvement of Lewis y through the detection of circulating immune complexes and association with Mucin 1 (MUC1).Q37346082
Increasing O-GlcNAc levels: An overview of small-molecule inhibitors of O-GlcNAcase.Q37576207
N-glycan structures: recognition and processing in the ER.Q37620688
Glycosynaptic microdomains controlling tumor cell phenotype through alteration of cell growth, adhesion, and motilityQ37623994
Metabolism, cell surface organization, and diseaseQ37671886
Mgat1-dependent N-glycans are essential for the normal development of both vertebrate and invertebrate metazoansQ37703536
Functional Roles of the Bisecting GlcNAc in Integrin-Mediated Cell AdhesionQ37785143
Modulation of E-cadherin function and dysfunction by N-glycosylation.Q37812004
The Tn antigen-structural simplicity and biological complexityQ37831859
O-GlcNAc in cancer biologyQ38120210
Chemical tools to probe cellular O-GlcNAc signalling.Q38155213
Complex N-glycans: the story of the "yellow brick road".Q38157785
Expression and function of α2,3‐sialyl‐ and α,3/l,4‐fucosyltransferases in colon adenocarcinoma cell lines: Role in synthesis of E‐selectin counter‐receptorsQ38289196
Increased glycosylation of beta 1 integrins affects the interaction of transformed S115 mammary epithelial cells with laminin-1.Q38293968
Inhibition of UDP-GlcNAc:Gal beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from acute myeloid leukaemia cells by photoreactive nitrophenyl substrate derivativesQ38311889
α2,3-Sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissuesQ38315106
Glycosyltransferases as cell adhesion moleculesQ38315602
Glycogenes mediate the invasive properties and chemosensitivity of human hepatocarcinoma cellsQ38320455
Effect of benzyl-alpha-GalNAc, an inhibitor of mucin glycosylation, on cancer-associated antigens in human colon cancer cellsQ38331636
Enhanced expression of alpha(1,3)-fucosyltransferase genes correlates with E-selectin-mediated adhesion and metastatic potential of human lung adenocarcinoma cells.Q38338605
Effects of swainsonine and polyinosinic:polycytidylic acid on murine tumor cell growth and metastasisQ38350429
Transcriptional regulation of the N-acetylglucosaminyltransferase V gene in human bile duct carcinoma cells (HuCC-T1) is mediated by Ets-1.Q38352116
Effects of tunicamycin on B16 metastatic melanoma cell surface glycoproteins and blood-borne arrest and survival propertiesQ38356075
Poly N-acetyllactosamine substitutions on N- and not O-oligosaccharides or Thomsen-Friedenreich antigen facilitate lung specific metastasis of melanoma cells via galectin-3.Q38359737
Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells.Q38845236
2-Deoxyglucose induces cell cycle arrest and apoptosisin colorectal cancer cells independent of its glycolysis inhibitionQ38902242
Inhibition of cancer cell growth by GRP78 siRNA lipoplex via activation of unfolded protein responseQ39008885
Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinomaQ39077984
ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51.Q39097758
The mucin-type glycosylating enzyme polypeptide N-acetylgalactosaminyltransferase 14 promotes the migration of ovarian cancer by modifying mucin 13.Q39147421
A novel I-branching beta-1,6-N-acetylglucosaminyltransferase involved in human blood group I antigen expressionQ34162929
O-GlcNAc signaling: a metabolic link between diabetes and cancer?Q34172895
Expression of sialyl-Tn antigen in breast cancer cells transfected with the human CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase (ST6GalNac I) cDNA.Q34207920
ABH and Lewis histo-blood group antigens in cancerQ34215529
Control of glycoprotein synthesis. Bovine colostrum UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase I. Separation from UDP-N-acetylglucosamine:alpha-D-mannoside beta 2-N-acetylglucosaminyltransferase II, partial [...]Q34260660
Association between expression levels of CA 19-9 and N-acetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissueQ34269464
Suppression of beta 1,3galactosyltransferase beta 3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly N-acetyllactosamines and sialyl-Lewis x on O-glycansQ34285184
Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration.Q34302948
A unique small molecule inhibitor of enolase clarifies its role in fundamental biological processesQ34336513
Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic conditionQ34337315
Histochemical demonstration and analysis of poly-N-acetyllactosamine structures in normal and malignant human tissuesQ34389864
Fucosyltransferases: structure/function studiesQ34392726
Lewis (y) antigen overexpression increases the expression of MMP-2 and MMP-9 and invasion of human ovarian cancer cellsQ34396078
Evidences for the involvement of cell surface glycans in stem cell pluripotency and differentiationQ34407362
Suppression of cancer progression by MGAT1 shRNA knockdown.Q34407965
Transcriptional regulation of N-acetylglucosaminyltransferase V by the src oncogeneQ34433644
The sweet and sour of cancer: glycans as novel therapeutic targetsQ34439560
The ST6GalNAc-I sialyltransferase localizes throughout the Golgi and is responsible for the synthesis of the tumor-associated sialyl-Tn O-glycan in human breast cancer.Q34471553
Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysisQ34549268
Suppression of core 1 Gal-transferase is associated with reduction of TF and reciprocal increase of Tn, sialyl-Tn and Core 3 glycans in human colon cancer cellsQ34639786
Increase of O-glycosylated oncofetal fibronectin in high glucose-induced epithelial-mesenchymal transition of cultured human epithelial cells.Q34673248
Mucin-type O-glycans in human colon and breast cancer: glycodynamics and functionsQ34683362
O-GlcNAc transferase integrates metabolic pathways to regulate the stability of c-MYC in human prostate cancer cells.Q34747232
Polypeptide N-acetylgalactosaminyltransferase 6 disrupts mammary acinar morphogenesis through O-glycosylation of fibronectinQ34763642
Molecular imaging of cancer with positron emission tomographyQ34810431
New castanospermine glycoside analogues inhibit breast cancer cell proliferation and induce apoptosis without affecting normal cellsQ35016962
Expression of a differentiation antigen and poly-N-acetyllactosaminyl O-glycans directed by a cloned core 2 beta-1,6-N-acetylglucosaminyltransferase.Q46426976
Synthesis of poly-N-acetyllactosamine in core 2 branched O-glycans. The requirement of novel beta-1,4-galactosyltransferase IV and beta-1,3-n-acetylglucosaminyltransferaseQ46525727
Altered melanoma cell surface glycosylation mediates organ specific adhesion and metastasis via lectin receptors on the lung vascular endotheliumQ46678523
Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cellsQ46828658
CD45 modulates galectin-1-induced T cell death: regulation by expression of core 2 O-glycansQ46897587
C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells.Q46898189
Lithocholic acid analogues, new and potent alpha-2,3-sialyltransferase inhibitors.Q46919457
Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG.Q46989470
Cell-cell interaction-dependent regulation of N-acetylglucosaminyltransferase III and the bisected N-glycans in GE11 epithelial cells. Involvement of E-cadherin-mediated cell adhesionQ46990459
Systematic nomenclature for sialyltransferasesQ48783973
Kinetic analysis of a recombinant UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase.Q50759829
Blood vessel invasion and expression of sialyl Lewisx and proliferating cell nuclear antigen in stage I non-small cell lung cancer. Relation to postoperative recurrence.Q50775156
Purification and characterization of UDP-GlcNAc:Gal beta 1-4Glc(NAc) beta-1,3-N-acetylglucosaminyltransferase (poly-N-acetyllactosamine extension enzyme) from calf serum.Q50777388
Optimised chemical synthesis of 5-substituted UDP-sugars and their evaluation as glycosyltransferase inhibitors.Q51756028
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues.Q51767552
O-GlcNAc transferase: a sweet new cancer target.Q53251909
Expression and enzyme activity of alpha(1,6)fucosyltransferase in human colorectal cancer.Q53321104
Enzymatic basis for the structural changes of asparagine-linked sugar chains of membrane glycoproteins of baby hamster kidney cells induced by polyoma transformation.Q53544439
Susceptibility of rat colon carcinoma cells to lymphokine activated killer-mediated cytotoxicity is decreased by alpha1,2-fucosylation.Q54052675
Prediction of bladder cancer based on urinary content of MGEA5 and OGT mRNA level.Q54301420
MUC1 in human and murine mammary carcinoma cells decreases the expression of core 2 β1,6-N-acetylglucosaminyltransferase and β-galactoside α2,3-sialyltransferase.Q54312855
UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (ppGalNAc-T6) mRNA as a potential new marker for detection of bone marrow-disseminated breast cancer cells.Q54610237
Chemo-enzymatic synthesis of fluorinated sugar nucleotide: useful mechanistic Probes for glycosyltransferasesQ56953153
Inhibition of experimental metastasis by castanospermine in mice: blockage of two distinct stages of tumor colonization by oligosaccharide processing inhibitorsQ58058353
Association of N-Glycosylation with Breast Carcinoma and Systemic Features Using High-Resolution Quantitative UPLCQ60531021
Novel Glycan Biomarkers for the Detection of Lung CancerQ60678388
Levels of specific serum N-glycans identify breast cancer patients with higher circulating tumor cell countsQ60678398
Regulation of Rat‐Liver Glycoprotein: N‐Acetylneuraminic Acid Transferase Activity by Pyrimidine NucleotidesQ67324054
Amphomycin inhibition of mannose and GlcNAc incorporation into lipid-linked saccharidesQ67417774
Poly-N-acetyllactosaminyl O-glycans attached to leukosialin. The presence of sialyl Le(x) structures in O-glycansQ67945544
Synthesis of a new inhibitor of the UDP-GalNAc:polypeptide galactosaminyl transferaseQ67986571
Evaluation of deoxygenated oligosaccharide acceptor analogs as specific inhibitors of glycosyltransferasesQ68010600
Beta 1-6 branched oligosaccharides as a marker of tumor progression in human breast and colon neoplasiaQ68179327
Blood group and blood-group-related antigens in normal pancreas and pancreas cancer: enhanced expression of precursor type 1, Tn and sialyl-Tn in pancreas cancerQ68183867
Glycosylation inhibitors for N-linked glycoproteinsQ69076427
Inhibition of experimental pulmonary metastasis of mouse colon adenocarcinoma 26 sublines by a sialic acid:nucleoside conjugate having sialyltransferase inhibiting activityQ69609449
E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V.Q39152300
Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumoursQ39169405
A correlation between altered O-GlcNAcylation, migration and with changes in E-cadherin levels in ovarian cancer cellsQ39176619
β-1,4-Galactosyltransferase III enhances invasive phenotypes via β1-integrin and predicts poor prognosis in neuroblastomaQ39187979
ppGalNAc T1 as a potential novel marker for human bladder cancer.Q39211086
Core2 O-glycan-expressing prostate cancer cells are resistant to NK cell immunityQ39242218
Swainsonine promotes apoptosis in human oesophageal squamous cell carcinoma cells in vitro and in vivo through activation of mitochondrial pathwayQ39244938
B4GALT1 gene knockdown inhibits the hedgehog pathway and reverses multidrug resistance in the human leukemia K562/adriamycin-resistant cell lineQ39268689
Estrogen induced β-1,4-galactosyltransferase 1 expression regulates proliferation of human breast cancer MCF-7 cellsQ39278007
The TF-antigen binding lectin from Sclerotium rolfsii inhibits growth of human colon cancer cells by inducing apoptosis in vitro and suppresses tumor growth in vivoQ39338882
MUC1 carrying core 2 O-glycans functions as a molecular shield against NK cell attack, promoting bladder tumor metastasisQ39374390
pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen.Q39401563
Functional analysis of α1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cellsQ39430940
Metabolic glycoengineering through the mammalian GalNAc salvage pathwayQ39431599
Down-regulation of FUT3 and FUT5 by shRNA alters Lewis antigens expression and reduces the adhesion capacities of gastric cancer cellsQ39462216
regulation of the invasion and metastasis of human glioma cells by polypeptide N-acetylgalactosaminyltransferase 2.Q39482946
O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantationQ39565095
O-GlcNAcylation is a novel regulator of lung and colon cancer malignancyQ39604562
A novel sialyltransferase inhibitor suppresses FAK/paxillin signaling and cancer angiogenesis and metastasis pathwaysQ39609194
Specificity of β1,4-galactosyltransferase inhibition by 2-naphthyl 2-butanamido-2-deoxy-1-thio-β-D-glucopyranosideQ39639800
Synthetic Antitumor Vaccines from Tetanus Toxoid Conjugates of MUC1 Glycopeptides with the Thomsen–Friedenreich Antigen and a Fluorine‐Substituted AnalogueQ39650206
Inhibitors of the biosynthesis and processing of N-linked oligosaccharide chainsQ39664965
Angiotensin AT1 receptor activation mediates high glucose-induced epithelial-mesenchymal transition in renal proximal tubular cells.Q39686680
Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral alpha-glucosidase inhibitory activity as antitumour agents.Q39692460
Molecular imaging of N-linked glycosylation suggests glycan biosynthesis is a novel target for cancer therapyQ39711705
Critical roles of mucin 1 glycosylation by transactivated polypeptide N-acetylgalactosaminyltransferase 6 in mammary carcinogenesisQ39730101
Nutrient sensor O-GlcNAc transferase regulates breast cancer tumorigenesis through targeting of the oncogenic transcription factor FoxM1.Q39734008
Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharidesQ39735775
A novel sialyltransferase inhibitor AL10 suppresses invasion and metastasis of lung cancer cells by inhibiting integrin-mediated signaling.Q39746392
Core 2 N-acetylglucosaminyltransferase-1 expression induces aggressive potential of testicular germ cell tumorQ39762155
alpha1,2-Fucosylated and beta-N-acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancerQ39763616
Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.Q39795184
High glucose-induced transforming growth factor beta1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cellsQ39796701
P921main subjectglycosylationQ898365
P304page(s)138
P577publication date2015-06-25
P1433published inFrontiers in OncologyQ26839986
P1476titleBiosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer
P478volume5