| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1517/14728222.2015.1067303 |
| P698 | PubMed publication ID | 26220155 |
| P2093 | author name string | Chen Wang | |
| Qin Zhou | |||
| Qiang Wang | |||
| Xing Liu | |||
| P2860 | cites work | DENV inhibits type I IFN production in infected cells by cleaving human STING | Q21131391 |
| Dengue virus targets the adaptor protein MITA to subvert host innate immunity | Q21558785 | ||
| Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases | Q22010206 | ||
| Mitochondrial DNA stress primes the antiviral innate immune response | Q23030015 | ||
| A Toll-like receptor recognizes bacterial DNA | Q24290668 | ||
| Activation of STAT6 by STING is critical for antiviral innate immunity | Q24293312 | ||
| Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity | Q24297286 | ||
| IFI16 is an innate immune sensor for intracellular DNA | Q24301720 | ||
| IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection | Q24302985 | ||
| Immune signaling by RIG-I-like receptors | Q24304438 | ||
| Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway | Q24306635 | ||
| The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA | Q24306840 | ||
| ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization | Q24310014 | ||
| RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate | Q24315639 | ||
| The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation | Q24316038 | ||
| RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway | Q24317317 | ||
| DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response | Q24317784 | ||
| AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC | Q24319706 | ||
| Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice | Q38347654 | ||
| Sensing and responding to cytosolic viruses invasions: An orchestra of kaleidoscopic ubiquitinations | Q38415543 | ||
| DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity | Q38908391 | ||
| The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling | Q38949484 | ||
| Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction | Q40437839 | ||
| The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING. | Q41590212 | ||
| Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling | Q41851410 | ||
| Dnase2a deficiency uncovers lysosomal clearance of damaged nuclear DNA via autophagy | Q42060185 | ||
| Adding to the STING. | Q42176514 | ||
| DAI (DLM-1/ZBP1) as a genetic adjuvant for DNA vaccines that promotes effective antitumor CTL immunity. | Q42208751 | ||
| Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis | Q42261339 | ||
| Features of systemic lupus erythematosus in Dnase1-deficient mice | Q42801296 | ||
| Bis-(3',5')-cyclic dimeric adenosine monophosphate: strong Th1/Th2/Th17 promoting mucosal adjuvant | Q44205583 | ||
| The E3 ubiquitin ligase RNF5 targets virus-induced signaling adaptor for ubiquitination and degradation | Q45375900 | ||
| Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus | Q50671884 | ||
| Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome. | Q51751254 | ||
| A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. | Q54631516 | ||
| TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines | Q56897738 | ||
| Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages | Q59062762 | ||
| STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors. | Q37502349 | ||
| The potential of 3',5'-cyclic diguanylic acid (c-di-GMP) as an effective vaccine adjuvant | Q37701568 | ||
| DNA vaccines: an historical perspective and view to the future | Q37825523 | ||
| Cyclic di-nucleotides: new era for small molecules as adjuvants. | Q37940637 | ||
| Immune sensing of DNA | Q38109307 | ||
| Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins | Q38129554 | ||
| STING-dependent cytosolic DNA sensing pathways | Q38169005 | ||
| Innate signaling in the inflammatory immune disorders | Q38227689 | ||
| IFI16: At the interphase between innate DNA sensing and genome regulation | Q38229892 | ||
| Role of DNA/RNA sensors and contribution to autoimmunity | Q38246400 | ||
| Self-DNA, STING-dependent signaling and the origins of autoinflammatory disease | Q38280213 | ||
| TLR9-/- and TLR9+/+ mice display similar immune responses to a DNA vaccine. | Q38337732 | ||
| AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA | Q24319765 | ||
| An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome | Q24319799 | ||
| STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling | Q24336398 | ||
| Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity | Q24337582 | ||
| The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells | Q24616649 | ||
| c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response | Q24616827 | ||
| A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP | Q24642631 | ||
| Trex1 prevents cell-intrinsic initiation of autoimmunity | Q24648757 | ||
| Roles of cyclic diguanylate in the regulation of bacterial pathogenesis | Q24656979 | ||
| Cytosolic sensing of viruses | Q26852473 | ||
| Species-specific detection of the antiviral small-molecule compound CMA by STING | Q27677466 | ||
| Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase | Q27678007 | ||
| Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity | Q27678294 | ||
| Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING | Q27678540 | ||
| The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop | Q27681456 | ||
| Pathogen recognition and innate immunity | Q27861084 | ||
| Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 | Q28115232 | ||
| Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA | Q28118718 | ||
| DNA vaccines: immunology, application, and optimization* | Q28145651 | ||
| Mutation of DNASE1 in people with systemic lupus erythematosus | Q28210015 | ||
| Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus | Q28252435 | ||
| Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation | Q28256216 | ||
| Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver | Q28508639 | ||
| STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity | Q28509328 | ||
| The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response | Q28510485 | ||
| Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA | Q28587147 | ||
| NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING | Q28975619 | ||
| The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses | Q29614469 | ||
| Recognition of cytosolic DNA activates an IRF3-dependent innate immune response | Q29616156 | ||
| RNF26 temporally regulates virus-triggered type I interferon induction by two distinct mechanisms | Q29871504 | ||
| Bruton's tyrosine kinase phosphorylates DDX41 and activates its binding of dsDNA and STING to initiate type 1 interferon response | Q30009223 | ||
| The prokaryote messenger c-di-GMP triggers stalk cell differentiation in Dictyostelium. | Q30573128 | ||
| c-di-GMP (3'-5'-cyclic diguanylic acid) inhibits Staphylococcus aureus cell-cell interactions and biofilm formation | Q33857476 | ||
| Innate immune sensing of DNA | Q33886132 | ||
| cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. | Q34084866 | ||
| Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling | Q34152661 | ||
| Endogenous circulating DNA in systemic lupus erythematosus. Occurrence as multimeric complexes bound to histone | Q34255110 | ||
| STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway | Q34259150 | ||
| TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination | Q34284881 | ||
| 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential | Q34303159 | ||
| Cyclic GMP-AMP displays mucosal adjuvant activity in mice | Q34309082 | ||
| Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid | Q34339243 | ||
| The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING | Q34346633 | ||
| Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects | Q34367481 | ||
| The mechanism of double-stranded DNA sensing through the cGAS-STING pathway | Q34624278 | ||
| Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease | Q34719398 | ||
| Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. | Q34745565 | ||
| A role for DNA-dependent activator of interferon regulatory factor in the recognition of herpes simplex virus type 1 by glial cells | Q35200588 | ||
| Binding-pocket and lid-region substitutions render human STING sensitive to the species-specific drug DMXAA. | Q35238345 | ||
| STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. | Q35263440 | ||
| DNase II: genes, enzymes and function | Q35596096 | ||
| Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis | Q35663520 | ||
| Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease | Q35717955 | ||
| Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production | Q35903465 | ||
| DNA degradation in development and programmed cell death | Q36072468 | ||
| Disrupting tumour blood vessels | Q36146900 | ||
| The chemotherapeutic agent DMXAA potently and specifically activates the TBK1-IRF-3 signaling axis | Q36229527 | ||
| STING manifests self DNA-dependent inflammatory disease | Q36436812 | ||
| Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules | Q36535512 | ||
| MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals | Q36845998 | ||
| STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. | Q37236401 | ||
| Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent | Q37340510 | ||
| RNA recognition and signal transduction by RIG-I-like receptors | Q37361441 | ||
| Pattern recognition receptors and control of adaptive immunity | Q37361471 | ||
| Antiviral defense: RIG-Ing the immune system to STING. | Q37391017 | ||
| The roles of TLRs, RLRs and NLRs in pathogen recognition | Q37402176 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | endoplasmic reticulum | Q79927 |
| bites and stings | Q54911704 | ||
| P304 | page(s) | 1397-1409 | |
| P577 | publication date | 2015-07-28 | |
| P1433 | published in | Expert Opinion on Therapeutic Targets | Q5421214 |
| P1476 | title | Cytosolic sensing of aberrant DNA: arming STING on the endoplasmic reticulum | |
| P478 | volume | 19 |
| Q38719858 | Cancer Immunotherapy: Selected Targets and Small-Molecule Modulators |
| Q42362086 | Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. |
| Q38864692 | High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins |
| Q37718357 | Intracellular STING inactivation sensitizes breast cancer cells to genotoxic agents |
| Q36251447 | SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing |
| Q53047113 | Small Molecules Drive Big Improvements in Immuno-Oncology Therapies. |
| Q36300913 | The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response. |
| Q47171677 | The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition |
| Q58618043 | The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway |
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