Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness

scientific article published on March 2014

Cholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CMET.2014.01.019
P932PMC publication ID3969850
P698PubMed publication ID24606897
P5875ResearchGate publication ID260644212

P50authorJunjie LiQ52681468
P2093author name stringTimothy L Ratliff
Ji-Xin Cheng
Liang Cheng
Bing Song
Xiaoqi Liu
Timothy A Masterson
Hyeon Jeong Lee
Shuhua Yue
Tian Shao
Seung-Young Lee
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Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cellsQ40002578
Human prostate cancer cells lack feedback regulation of low-density lipoprotein receptor and its regulator, SREBP2.Q40833413
Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP.Q41120850
Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP.Q41164689
The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factorQ41731121
Lipid droplets finally get a little R-E-S-P-E-C-T.Q41828556
Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cellsQ42457991
High ACAT1 expression in estrogen receptor negative basal-like breast cancer cells is associated with LDL-induced proliferationQ42461741
Lipofuscin granules in normal, benign and malignant human prostatic tissueQ43465734
Fatty acid regulates gene expression and growth of human prostate cancer PC-3 cellsQ43589116
Establishment and characterization of androgen-independent human prostate cancer LNCaP cell modelQ43900265
Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independenceQ44802900
Mechanisms of androgen-refractory prostate cancerQ45094999
Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancerQ46923183
High throughput quantification of cholesterol and cholesteryl ester by electrospray ionization tandem mass spectrometry (ESI-MS/MS).Q46928125
Androgen-Independent Prostate Cancer Is a Heterogeneous Group of DiseasesQ57693579
Cholesterol esters as growth regulators of lymphocytic leukaemia cellsQ60540979
Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examplesQ69740657
Enhancement of the LC/MS analysis of fatty acids through derivatization and stable isotope codingQ80306826
The phosphatidylinositol 3-Kinase AKT pathway in human cancerQ29547860
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesisQ29615683
Abiraterone and increased survival in metastatic prostate cancerQ29617512
Arachidonic acid stimulates prostate cancer cell growth: critical role of 5-lipoxygenaseQ30470670
Quantitative label-free imaging of lipid composition and packing of individual cellular lipid droplets using multiplex CARS microscopyQ30484406
Highly Sensitive Vibrational Imaging by Femtosecond Pulse Stimulated Raman LossQ30501662
Remodeling of lipid droplets during lipolysis and growth in adipocytesQ30512876
Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2Q30523968
1H NMR visible lipids in the life and death of cellsQ30604603
Nonperturbative chemical imaging of organelle transport in living cells with coherent anti-stokes Raman scattering microscopyQ33240794
Fatty acid synthase: a metabolic enzyme and candidate oncogene in prostate cancerQ33421665
High-speed vibrational imaging and spectral analysis of lipid bodies by compound Raman microscopyQ33440785
Dietary fat and prostate cancer: current statusQ33539814
Metabolomic characterization of human prostate cancer bone metastases reveals increased levels of cholesterolQ33769607
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesisQ33914549
Eicosanoids and cancerQ33966203
The biogenesis and functions of lipid bodies in animals, plants and microorganismsQ34084932
Shedding new light on lipid biology with coherent anti-Stokes Raman scattering microscopyQ34187941
Pharmacology of the ACAT inhibitor avasimibe (CI-1011).Q35069596
Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growthQ35168294
Polo-like kinase 1 facilitates loss of Pten tumor suppressor-induced prostate cancer formationQ35371690
Targeting the PI3K-Akt pathway in human cancer: rationale and promiseQ35571372
Label-free imaging of lipid-droplet intracellular motion in early Drosophila embryos using femtosecond-stimulated Raman loss microscopy.Q35866792
Monitoring of lipid storage in Caenorhabditis elegans using coherent anti-Stokes Raman scattering (CARS) microscopyQ35990206
Cholesterol sensing, trafficking, and esterification.Q36497100
The role of cholesterol in prostate cancerQ36508469
Statin drugs and risk of advanced prostate cancerQ36688183
Cellular cholesterol trafficking and compartmentalizationQ37064008
PTEN and the PI3-kinase pathway in cancerQ37259680
Targeting the PI3K/AKT pathway for the treatment of prostate cancerQ37564760
Lipid metabolism in cancerQ38012542
How cancer metabolism is tuned for proliferation and vulnerable to disruptionQ38059777
Nonlinear vibrational microscopy applied to lipid biology.Q38139725
Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.Q38467346
An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathwayQ38926285
Comparative effects of high and low-dose simvastatin on prostate epithelial cells: the role of LDL.Q39450194
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)393-406
P577publication date2014-03-01
P1433published inCell MetabolismQ1254684
P1476titleCholesteryl ester accumulation induced by PTEN loss and PI3K/AKT activation underlies human prostate cancer aggressiveness
P478volume19

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