Multifunctional non-coding Epstein-Barr virus encoded RNAs (EBERs) contribute to viral pathogenesis

scientific article published on 17 August 2015

Multifunctional non-coding Epstein-Barr virus encoded RNAs (EBERs) contribute to viral pathogenesis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.VIRUSRES.2015.08.007
P698PubMed publication ID26292159

P2093author name stringDai Iwakiri
P2860cites workHuman effector CD8+ T lymphocytes express TLR3 as a functional coreceptor.Q42605140
A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responsesQ43939988
The La antigen shuttles between the nucleus and the cytoplasm in CV-1 cellsQ44308139
Epstein-Barr virus-encoded small RNA induces IL-10 through RIG-I-mediated IRF-3 signalingQ44318736
New variations of Epstein-Barr virus-encoded small RNA genes in nasopharyngeal carcinomas, gastric carcinomas, and healthy donors in northern ChinaQ45377303
Ribosomal protein L22 inhibits regulation of cellular activities by the Epstein-Barr virus small RNA EBER-1.Q45643251
Differential cellular targets of Epstein-Barr virus (EBV) infection between acute EBV-associated hemophagocytic lymphohistiocytosis and chronic active EBV infectionQ45735795
Heterogeneity of HLA and EBER expression in Epstein-Barr virus-associated nasopharyngeal carcinomaQ45739568
Detection of Epstein-Barr virus in oral papillomaQ45754313
Epstein-Barr virus (EBV) infection in salivary gland tumors: lytic EBV infection in nonmalignant epithelial cells surrounded by EBV-positive T-lymphoma cellsQ45764926
Expression of genes for the Epstein-Barr virus small RNAs EBER-1 and EBER-2 in Daudi Burkitt's lymphoma cells: effects of interferon treatmentQ45876131
Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cellsQ47978435
APC-independent activation of NK cells by the Toll-like receptor 3 agonist double-stranded RNAQ75197384
Expression and processing of a small nucleolar RNA from the Epstein-Barr virus genomeQ21090514
The viral and cellular microRNA targetome in lymphoblastoid cell linesQ21131404
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferonQ24301655
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemiaQ24311601
mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive propertiesQ24530264
Multiple domains of EBER 1, an Epstein-Barr virus noncoding RNA, recruit human ribosomal protein L22Q24543923
Identification of two RNA-binding proteins associated with human telomerase RNAQ24548517
The 3;21 translocation in myelodysplasia results in a fusion transcript between the AML1 gene and the gene for EAP, a highly conserved protein associated with the Epstein-Barr virus small RNA EBER 1Q24561767
The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytesQ24563545
Toll-like receptor signallingQ24570126
Biogenesis and function of multivesicular bodiesQ24601502
AUF1/hnRNP D is a novel protein partner of the EBER1 noncoding RNA of Epstein-Barr virusQ24624988
Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosusQ24634814
The members of an Epstein-Barr virus microRNA cluster cooperate to transform B lymphocytesQ24634928
A mammalian microRNA expression atlas based on small RNA library sequencingQ24644709
An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survivalQ24649032
Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressedQ25257225
A novel persistence associated EBV miRNA expression profile is disrupted in neoplasiaQ27349177
Hepatitis C Virus 3'X Region Interacts with Human Ribosomal ProteinsQ27469767
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3Q27860854
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
5'-Triphosphate RNA is the ligand for RIG-IQ28131726
The widespread regulation of microRNA biogenesis, function and decayQ28131796
Identification of microRNAs of the herpesvirus familyQ29618671
Functional delivery of viral miRNAs via exosomesQ29619574
Epstein-Barr virus noncoding RNAs are confined to the nucleus, whereas their partner, the human La protein, undergoes nucleocytoplasmic shuttlingQ30444219
Localization of Epstein-Barr virus-encoded RNAs EBER-1 and EBER-2 in interphase and mitotic Burkitt lymphoma cellsQ30794920
A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized miceQ33394809
Lymphoid hyperplasia and lymphoma in transgenic mice expressing the small non-coding RNA, EBER1 of Epstein-Barr virusQ33531732
Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNAQ33625562
Micro RNAs of Epstein-Barr Virus Promote Cell Cycle Progression and Prevent Apoptosis of Primary Human B CellsQ33680515
Characterization of Epstein-Barr Virus miRNAome in Nasopharyngeal Carcinoma by Deep SequencingQ33700293
The binding site of the RNA-dependent protein kinase (PKR) on EBER1 RNA from Epstein-Barr virusQ33758060
EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3Q33793531
A viral microRNA cluster strongly potentiates the transforming properties of a human herpesvirusQ33838266
Epstein-Barr virus small nuclear RNAs are not expressed in permissively infected cells in AIDS-associated leukoplakiaQ33891606
Malignant transformation of B lymphoma cell line BJAB by Epstein-Barr virus-encoded small RNAsQ33924474
Multiple functions are mediated by the miRNAs of Epstein-Barr virusQ34112079
Human tumor virus utilizes exosomes for intercellular communication.Q34377767
Virus-encoded microRNAs: an overview and a look to the futureQ34544400
MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAsQ34593731
Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNAQ35036524
LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activationQ35052575
Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAsQ35127714
Epstein-Barr virus-encoded small RNAs (EBERs) are present in fractions related to exosomes released by EBV-transformed cellsQ35181445
High prevalence of the EBER variant EB-8m in endemic nasopharyngeal carcinomasQ35586536
In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA librariesQ35852608
The Epstein-Barr Virus BART microRNAs target the pro-apoptotic protein Bim.Q35924384
EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latencyQ35932258
Camels and zebrafish, viruses and cancer: a microRNA updateQ36294678
Structure of genes for virus-associated RNAI and RNAII of adenovirus type 2.Q36386607
Viruses and microRNAsQ36493262
Functions of microRNAs and related small RNAs in plantsQ36493266
Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responsesQ36500879
Identification of transcribed regions of Epstein-Barr virus DNA in Burkitt lymphoma-derived cellsQ36502732
The role of AUF1 in regulated mRNA decayQ36717222
Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free systemQ36747113
Function of RIG-I-like receptors in antiviral innate immunityQ36774929
Epstein-Barr virus maintains lymphomas via its miRNAs.Q36948327
Striking similarities are exhibited by two small Epstein-Barr virus-encoded ribonucleic acids and the adenovirus-associated ribonucleic acids VAI and VAII.Q36957370
Viral dsRNA inhibitors prevent self-association and autophosphorylation of PKR.Q37008351
Two small RNAs encoded by Epstein-Barr virus can functionally substitute for the virus-associated RNAs in the lytic growth of adenovirus 5Q37344746
Growth-promoting properties of Epstein-Barr virus EBER-1 RNA correlate with ribosomal protein L22 bindingQ37355983
Analysis of human alphaherpesvirus microRNA expression in latently infected human trigeminal gangliaQ37365331
Localization of Epstein-Barr virus-encoded small RNAs by in situ hybridizationQ37409158
Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAsQ37491595
The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunitiesQ37974382
MicroRNAs as mediators of viral evasion of the immune systemQ38082296
The cellular RNA-binding protein EAP recognizes a conserved stem-loop in the Epstein-Barr virus small RNA EBER 1.Q38322996
Epstein-Barr virus small RNA (EBER) genes: unique transcription units that combine RNA polymerase II and III promoter elementsQ38344383
A primate herpesvirus uses the integrator complex to generate viral microRNAsQ38528105
Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomasQ39023364
Exosomes derived from Epstein-Barr virus-infected cells are internalized via caveola-dependent endocytosis and promote phenotypic modulation in target cells.Q39124304
Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β productionQ39277512
Epstein-Barr virus small RNAs potentiate tumorigenicity of Burkitt lymphoma cells independently of an effect on apoptosisQ39539644
Cellular gene expression that correlates with EBER expression in Epstein-Barr Virus-infected lymphoblastoid cell linesQ39605687
Epstein-Barr virus RNA confers resistance to interferon-alpha-induced apoptosis in Burkitt's lymphomaQ39646759
Systematic analysis of viral and cellular microRNA targets in cells latently infected with human gamma-herpesviruses by RISC immunoprecipitation assayQ39711736
Epstein-Barr virus infection in immortalized nasopharyngeal epithelial cells: regulation of infection and phenotypic characterization.Q39749474
Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivationQ39763904
Epstein-Barr virus (EBV)-encoded small RNA is released from EBV-infected cells and activates signaling from Toll-like receptor 3.Q39805733
The microRNAs of Epstein-Barr Virus are expressed at dramatically differing levels among cell linesQ39883935
La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity.Q40065925
Epstein-Barr virus (EBV)-encoded RNA 2 (EBER2) but not EBER1 plays a critical role in EBV-induced B-cell growth transformationQ40096496
Two families of sequences in the small RNA-encoding region of Epstein-Barr virus (EBV) correlate with EBV types A and B.Q40100585
Oncogenic role of Epstein-Barr virus-encoded small RNAs (EBERs) in nasopharyngeal carcinomaQ40204013
Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytesQ40213284
EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN.Q40237206
Stable expression of EBERs in immortalized nasopharyngeal epithelial cells confers resistance to apoptotic stress.Q40387417
Epstein-Barr virus-encoded poly(A)(-) RNA supports Burkitt's lymphoma growth through interleukin-10 inductionQ40388552
Epstein-Barr virus-encoded small RNA induces insulin-like growth factor 1 and supports growth of nasopharyngeal carcinoma-derived cell lines.Q40479182
A cluster of virus-encoded microRNAs accelerates acute systemic Epstein-Barr virus infection but does not significantly enhance virus-induced oncogenesis in vivoQ40529310
Epstein-Barr virus (EBV)-encoded RNA promotes growth of EBV-infected T cells through interleukin-9 inductionQ40529464
Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI.Q40530889
Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomasQ42007977
Critical role of Epstein-Barr Virus (EBV)-encoded RNA in efficient EBV-induced B-lymphocyte growth transformationQ42122014
Nasopharyngeal carcinoma progression is mediated by EBER-triggered inflammation via the RIG-I pathwayQ42159282
P921main subjectEpstein–Barr virusQ6900
P304page(s)30-38
P577publication date2015-08-17
P1433published inVirus ResearchQ15749215
P1476titleMultifunctional non-coding Epstein-Barr virus encoded RNAs (EBERs) contribute to viral pathogenesis
P478volume212

Reverse relations

cites work (P2860)
Q99711932A survey of RNA secondary structural propensity encoded within human herpesvirus genomes: global comparisons and local motifs
Q39016336Current Trends and Alternative Scenarios in EBV Research
Q52340925Exosomes in Nasopharyngeal Carcinoma.
Q36380247Expression profile of Epstein-Barr virus and human adenovirus small RNAs in tonsillar B and T lymphocytes
Q47586766Extracellular vesicles: novel vehicles in herpesvirus infection.
Q54225670Long Non-Coding RNAs: Novel Players in Regulation of Immune Response Upon Herpesvirus Infection.
Q36553653Long noncoding RNAs in viral infections
Q60930576MiR-3470b promotes bovine ephemeral fever virus replication via directly targeting mitochondrial antiviral signaling protein (MAVS) in baby hamster Syrian kidney cells
Q59351571More than just oncogenes: mechanisms of tumorigenesis by human viruses
Q47304703RNA2DMut: A web tool for the design and analysis of RNA structure mutations
Q26747049Recent advances in primary Sjogren's syndrome
Q39365927Roles of LncRNAs in Viral Infections
Q41919859Rotavirus-encoded virus-like small RNA triggers autophagy by targeting IGF1R via the PI3K/Akt/mTOR pathway
Q61809078The Opening of Pandora's Box: An Emerging Role of Long Noncoding RNA in Viral Infections
Q47425387The regulatory role of protein phosphorylation in human gammaherpesvirus associated cancers.
Q101155923The roles of miRNAs and lncRNAs in Epstein-Barr virus associated epithelial cell tumors
Q64076950The search for a PKR code-differential regulation of protein kinase R activity by diverse RNA and protein regulators
Q64226989Viral RNA structure-based strategies to manipulate translation

Search more.