Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics

scientific article published on 18 September 2015

Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics is …
instance of (P31):
scholarly articleQ13442814

External links are
P5530Altmetric DOI10.1007/S12265-015-9655-Z
P6179Dimensions Publication ID1047584932
P356DOI10.1007/S12265-015-9655-Z
P698PubMed publication ID26385009
P1154Scopus EID2-s2.0-84947488811

P50authorSreenivasan PonnambalamQ38801053
Stephen WheatcroftQ43402450
David A RussellQ52852593
P2093author name stringSreenivasan Ponnambalam
Shervanthi Homer-Vanniasinkam
Izma Abdul Zani
Jonathan De Siqueira
P2860cites workAn endothelial receptor for oxidized low-density lipoproteinQ24323462
Identification of the lectin-like receptor for oxidized low-density lipoprotein in human macrophages and its potential role as a scavenger receptorQ24531178
Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritisQ28239197
Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammationQ28566134
LOX-1 inhibition in myocardial ischemia-reperfusion injury: modulation of MMP-1 and inflammationQ28583634
Molecular imaging of atherosclerotic plaques targeted to oxidized LDL receptor LOX-1 by SPECT/CT and magnetic resonanceQ30434516
Role of LOX-1 and ROS in oxidized low-density lipoprotein induced epithelial-mesenchymal transition of NRK52EQ30990551
Significance of soluble lectin-like oxidized LDL receptor-1 levels in systemic and coronary circulation in acute coronary syndrome.Q33660782
Effects of clopidogrel added to aspirin in patients with recent lacunar strokeQ33792318
Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. ATTRACT Study GroupQ33885648
Safety and pharmacokinetics of an intramuscular monoclonal antibody (SB 209763) against respiratory syncytial virus (RSV) in infants and young children at risk for severe RSV diseaseQ33976286
LOX-1 in atherosclerosis: biological functions and pharmacological modifiers.Q34079451
Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trialQ34092311
OxLDL-dependent activation of arginase II is dependent on the LOX-1 receptor and downstream RhoA signalingQ34543359
High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trialQ34562602
Pathology of the thin-cap fibroatheroma: a type of vulnerable plaqueQ35151273
The oxidized low-density lipoprotein receptor mediates vascular effects of inhaled vehicle emissionsQ35212599
Expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in human preeclamptic placenta: possible implications in the process of trophoblast apoptosis.Q53626605
Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2).Q54005785
Blockade of LOX-1 prevents endotoxin-induced acute lung inflammation and injury in mice.Q55224652
Expression of lectin-like oxidized low-density lipoprotein receptors during ischemia-reperfusion and its role in determination of apoptosis and left ventricular dysfunctionQ73158540
Identification of soluble forms of lectin-like oxidized LDL receptor-1Q73536903
LOX-1 supports adhesion of Gram-positive and Gram-negative bacteriaQ73720901
Transforming growth factor-beta(1) increases the expression of lectin-like oxidized low-density lipoprotein receptor-1Q73838277
Intrathecal 131I-labeled antitenascin monoclonal antibody 81C6 treatment of patients with leptomeningeal neoplasms or primary brain tumor resection cavities with subarachnoid communication: phase I trial resultsQ77557098
Lectin-like oxidized low-density lipoprotein receptor 1 mediates leukocyte infiltration and articular cartilage destruction in rat zymosan-induced arthritisQ78301208
Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilageQ80969872
Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 levels are elevated in acute coronary syndrome: a novel marker for early diagnosisQ80976759
Up-regulation of LOX-1 expression by TNF-alpha promotes trans-endothelial migration of MDA-MB-231 breast cancer cellsQ81296828
Lectin-like oxidized low-density lipoprotein receptor 1 signal is a potent biomarker and therapeutic target for human rheumatoid arthritisQ82470746
Serum sLOX-1 levels are associated with the presence and severity of angiographic coronary artery disease in patients with metabolic syndromeQ82753008
Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a sensitive and specific biomarker for acute coronary syndrome--comparison with other biomarkersQ84531189
Protein kinase C-alpha activation induces NF-kB-dependent VCAM-1 expression in cultured human umbilical vein endothelial cells treated with sera from preeclamptic patientsQ84956624
Monoclonal antibodies: magic bullets with a hefty price tagQ85648827
Endothelial damage in white coat hypertension: role of lectin-like oxidized low-density lipoprotein-1Q87374197
Soluble Lectin-Like Oxidized LDL Receptor 1 as a Possible Mediator of Endothelial Dysfunction in Patients With Metabolic SyndromeQ87814798
Inhibition of lectin-like oxidized low-density lipoprotein receptor-1 reduces leukocyte adhesion within the intestinal microcirculation in experimental endotoxemia in rats.Q35561312
Pharmacokinetics of therapeutic monoclonal antibodies used in oncologyQ36218497
Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal womenQ37181325
Safety assessment and dose selection for first-in-human clinical trials with immunomodulatory monoclonal antibodiesQ37379764
The safety and side effects of monoclonal antibodiesQ37715703
Lifestyle and cardiovascular disease in JapanQ37838640
LOX-1 and angiotensin receptors, and their interplayQ37921158
Lectin-like oxidized low-density lipoprotein receptor 1 pathways.Q38099693
Statin treatment for primary prevention of vascular disease: whom to treat? Cost-effectiveness analysis.Q38464443
CRP is a novel ligand for the oxidized LDL receptor LOX-1.Q39878373
LOX index, a novel predictive biochemical marker for coronary heart disease and stroke.Q39915945
Anti-LOX-1 therapy in rats with diabetes and dyslipidemia: ablation of renal vascular and epithelial manifestationsQ40055172
LOX-1 scavenger receptor mediates calcium-dependent recognition of phosphatidylserine and apoptotic cellsQ40376526
Oxidized low density lipoprotein induces apoptosis via generation of reactive oxygen species in vascular smooth muscle cellsQ42497396
Oxidized LDL modulates Bax/Bcl-2 through the lectinlike Ox-LDL receptor-1 in vascular smooth muscle cellsQ43633677
PPARgamma ligands inhibit TNF-alpha-induced LOX-1 expression in cultured endothelial cells.Q43711390
Lectin-like oxidized low-density lipoprotein receptor-1 plays an important role in vascular inflammation in current smokersQ43975643
Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL).Q44071979
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disordersQ44150789
LOX-1 mediates oxidized low-density lipoprotein-induced expression of matrix metalloproteinases in human coronary artery endothelial cellsQ44302094
Role of caspases in Ox-LDL-induced apoptotic cascade in human coronary artery endothelial cellsQ44698977
Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol dietQ45867832
Deletion of LOX-1 attenuates renal injury following angiotensin II infusion.Q45953889
Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaqueQ46365505
Interleukin 18 stimulates release of soluble lectin-like oxidized LDL receptor-1 (sLOX-1).Q46565716
LOX-1 deletion decreases collagen accumulation in atherosclerotic plaque in low-density lipoprotein receptor knockout mice fed a high-cholesterol dietQ46614178
Soluble lectin-like oxidized low density lipoprotein receptor-1 in type 2 diabetes mellitusQ46648050
Simulative and experimental investigation on the cleavage site that generates the soluble human LOX-1.Q46930171
Lectin-like oxidized low density lipoprotein receptor 1 (LOX-1) expression in human articular chondrocytes.Q46987456
Expression of lectin-like oxidized LDL receptor-1 in smooth muscle cells after vascular injuryQ47650458
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathyQ48732854
LOX-1 mediates vascular lipid retention under hypertensive state.Q50446964
LOX-1 is a novel therapeutic target in neonatal hypoxic-ischemic encephalopathy.Q50648730
Soluble lectin-like oxidized LDL receptor-1 (sLOX-1) as a valuable diagnostic marker for rupture of thin-cap fibroatheroma: verification by optical coherence tomography.Q51029154
Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model.Q51813661
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)458-465
P577publication date2015-09-18
P1433published inJournal of Cardiovascular Translational ResearchQ6294906
P1476titleClinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and Therapeutics
P478volume8

Reverse relations

Q33564156Lectin-type oxidized LDL receptor-1 distinguishes population of human polymorphonuclear myeloid-derived suppressor cells in cancer patients.cites workP2860

Search more.