NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells

scientific article published on 11 August 2013

NFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1024059768
P356DOI10.1007/S10616-013-9585-Z
P932PMC publication ID3973803
P698PubMed publication ID23934330

P2093author name stringYuji Kashiwakura
Shogo Tokudome
Masaaki Hashiguchi
Hidefumi Kojima
Akira Kurosu
Tetsuji Kobata
Yumiko Kanno
Ayano Kobayashi
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CD4(-)c-kit(-)CD3epsilon(-)IL-2Ralpha(+) Peyer's patch cells are a novel cell subset which secrete IL-5 in response to IL-2: implications for their role in IgA productionQ47299650
CD28 costimulation controls histone hyperacetylation of the interleukin 5 gene locus in developing th2 cellsQ47897416
T cell-intrinsic expression of c-Rel regulates Th1 cell responses essential for resistance to Toxoplasma gondiiQ47991732
Eomesodermin controls interleukin-5 production in memory T helper 2 cells through inhibition of activity of the transcription factor GATA3.Q50981198
The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation.Q51738175
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Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.Q53026962
Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elementsQ57228054
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GATA-3-dependent enhancer activity in IL-4 gene regulationQ61357104
Molecular properties and regulation of mRNA expression for murine T cell-replacing factor/IL-5Q69913489
Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytesQ70461004
p38 mitogen-activated protein kinase regulates human T cell IL-5 synthesisQ73098769
GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-betQ73153297
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A novel transcription factor, T-bet, directs Th1 lineage commitmentQ22253874
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokinesQ24294720
STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cellsQ24534351
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The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
NF-AT components define a family of transcription factors targeted in T-cell activationQ28114991
Transcription factors of the NFAT family: regulation and functionQ28237645
Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cellsQ28302789
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Opposing roles for RelB and Bcl-3 in regulation of T-box expressed in T cells, GATA-3, and Th effector differentiationQ28513506
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gammaQ28590652
Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseasesQ29547555
TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional propertiesQ29547848
The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cellsQ29614226
Plat-E: an efficient and stable system for transient packaging of retrovirusesQ29614830
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Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiationQ34796730
GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cellsQ35834668
T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcriptionQ36228437
Essential role of nuclear factor kappaB in the induction of eosinophilia in allergic airway inflammationQ36401739
IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508.Q36403717
Regulation of Th2 differentiation and Il4 locus accessibility.Q36427376
Epigenetic control of T-helper-cell differentiationQ37371624
Interleukin 5 in the link between the innate and acquired immune responseQ37397525
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Protein kinase A regulates GATA-3-dependent activation of IL-5 gene expression in Th2 cellsQ40665498
P433issue3
P304page(s)373-382
P577publication date2013-08-11
P1433published inCytotechnologyQ15752151
P1476titleNFκB attenuates IL-5 production and upregulates T-box transcription factors in Th2-like T cells
P478volume66