Physicochemical interaction of antitumor acridinone derivatives with DNA in view of QSAR studies.

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Physicochemical interaction of antitumor acridinone derivatives with DNA in view of QSAR studies. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00044-010-9487-Y
P932PMC publication ID3185225
P698PubMed publication ID22003274
P5875ResearchGate publication ID51720228

P50authorTomasz BaczekQ56849433
Marcin KobaQ61994361
P2860cites workThe relevance of enzymatic oxidation by horseradish peroxidase to antitumour potency of imidazoacridinone derivativesQ77561034
Molecular mechanism of the enzymatic oxidation investigated for imidazoacridinone antitumor drug, C-1311Q79175571
Antitumour imidazoacridone C-1311 induces cell death by mitotic catastrophe in human colon carcinoma cellsQ81400239
Induction of unique structural changes in guanine-rich DNA regions by the triazoloacridone C-1305, a topoisomerase II inhibitor with antitumor activitiesQ24811057
Cell killing by the novel imidazoacridinone antineoplastic agent, C-1311, is inhibited at high concentrations coincident with dose-differentiated cell cycle perturbationQ36136247
Preclinical evaluation of novel imidazoacridinone derivatives with potent activity against experimental colorectal cancerQ36136293
Cellular uptake, cytotoxicity and DNA-binding studies of the novel imidazoacridinone antineoplastic agent C1311.Q36619630
Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cellsQ36641685
Pharmacological and toxicological aspects of new imidazoacridinone antitumor agentsQ36797525
Comparative cytotoxicity of C-1311 in colon cancer in vitro and in vivo using the hollow fiber assayQ40036736
Comparative evaluation of C1311 cytotoxic activity and interference with cell cycle progression in a panel of human solid tumour and leukaemia cell lines.Q40085052
C421 allele-specific ABCG2 gene amplification confers resistance to the antitumor triazoloacridone C-1305 in human lung cancer cells.Q40137056
Induction of G2/M phase arrest and apoptosis of human leukemia cells by potent antitumor triazoloacridinone C-1305.Q40232516
Cell growth inhibition, G2M cell cycle arrest and apoptosis induced by the imidazoacridinone C1311 in human tumour cell linesQ40778077
In vivo metabolism of the antitumor imidazoacridinone C1311 in the mouse and in vitro comparison with humans.Q42536366
The antitumor triazoloacridone C-1305 is a topoisomerase II poison with unusual propertiesQ42827284
Interactions of antitumor triazoloacridinones with DNA.Q42829013
Increased susceptibility of poly(ADP-ribose) polymerase-1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrestQ44961884
Development and validation of an LC-UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage formQ46495454
Pharmaceutical development of a parenteral lyophilised dosage form for the novel anticancer agent C1311.Q46826201
Compatibility and stability of the novel anti-cancer agent C1311 in infusion devices and its in vitro biocompatibilityQ46929841
Sequential induction of mitotic catastrophe followed by apoptosis in human leukemia MOLT4 cells by imidazoacridinone C-1311.Q46960032
Experimental antitumor activity and toxicity of the selected triazolo- and imidazoacridinones.Q51040409
Retention prediction of peptides based on uninformative variable elimination by partial least squares.Q51938282
QSAR of acridines, III. Structure-activity relationship for antitumour imidazoacridinones and intercorrelations between in vivo and in vitro tests.Q52320015
Chromophore-modified antineoplastic imidazoacridinones. Synthesis and activity against murine leukemiasQ67733861
8-Substituted 5-[(aminoalkyl)amino]-6H-v-triazolo[4,5,1-de]acridin-6-ones as potential antineoplastic agents. Synthesis and biological activityQ68560515
Inhibition of DNA topoisomerase II by imidazoacridinones, new antineoplastic agents with strong activity against solid tumorsQ71061316
Structure-activity relationship for antineoplastic imidazoacridinones: synthesis and antileukemic activity in vivoQ71176181
Intercalation of imidazoacridinones to DNA and its relevance to cytotoxic and antitumor activityQ74084156
The intercalation of imidazoacridinones into DNA induces conformational changes in their side chainQ74231882
Pharmacokinetics and tissue distribution of the imidazoacridinone C1311 in tumour-bearing miceQ77408664
P433issue8
P304page(s)1385-1393
P577publication date2010-11-17
P1433published inMedicinal Chemistry ResearchQ3304000
P1476titlePhysicochemical interaction of antitumor acridinone derivatives with DNA in view of QSAR studies
P478volume20

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cites work (P2860)
Q38213469Acridine and its derivatives: a patent review (2009 - 2013).
Q34718278Acridone derivative 8a induces oxidative stress-mediated apoptosis in CCRF-CEM leukemia cells: application of metabolomics in mechanistic studies of antitumor agents
Q49417795Acridone suppresses the proliferation of human breast cancer cells in vitro via ATP-binding cassette subfamily G member 2.
Q38986162Synthesis, characterization and biological evaluation of carboranylmethylbenzo[b]acridones as novel agents for boron neutron capture therapy

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