Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin.

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Involvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin. is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0183565
P932PMC publication ID5568415
P698PubMed publication ID28832656

P50authorHala F. ZakiQ53791624
Rehab HegazyQ87486307
P2093author name stringAzza Hassan
Amina Attia
Nawal Gomaa
Sara Kenawy
Siham El-Shenawy
P2860cites workComparison of caffeine-induced locomotor activity between adolescent and adult rats.Q51870382
Aging and Alzheimer's disease: lessons from the Nun Study.Q53217158
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's diseaseQ57132920
Improved method for the determination of blood glutathioneQ79579725
Adenosine monophosphate-activated protein kinase in diabetic nephropathyQ26745623
Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathwaysQ28396841
Insulin signallingQ28611467
Assay for lipid peroxides in animal tissues by thiobarbituric acid reactionQ29616762
Metformin attenuates Alzheimer's disease-like neuropathology in obese, leptin-resistant miceQ30419141
Senescence-accelerated OXYS rats: a model of age-related cognitive decline with relevance to abnormalities in Alzheimer diseaseQ30760387
The Role of Ethnicity in Alzheimer's Disease: Findings From The C-PATH Online Data Repository.Q31047635
Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer's diseaseQ33887359
Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesisQ34112184
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholineQ34474707
Methods for detection of reactive metabolites of oxygen and nitrogen: in vitro and in vivo considerationsQ35648421
Glycogen synthase kinase 3: a drug target for CNS therapiesQ35800094
Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 PathwayQ35858703
Insulin resistance, inflammation, and cognition in Alzheimer's Disease: lessons for multiple sclerosisQ36456393
Diabetes medications: Impact on inflammation and wound healingQ36805643
Immunomodulatory effect of tumor necrosis factorQ37764567
Linking Alzheimer's disease to insulin resistance: the FoxO response to oxidative stressQ37802185
Synapses, NMDA receptor activity and neuronal Aβ production in Alzheimer's disease.Q37875108
Brain insulin signaling: a key component of cognitive processes and a potential basis for cognitive impairment in type 2 diabetesQ37930196
The senescence hypothesis of disease progression in Alzheimer disease: an integrated matrix of disease pathways for FAD and SAD.Q38094984
Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer's Disease: in Search of a Relevant MechanismQ38368300
Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy ActivationQ38416332
AMPK-mediated regulation of neuronal metabolism and function in brain diseasesQ38539535
Targeting Insulin Signaling for the Treatment of Alzheimer's DiseaseQ38565622
Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System.Q38718365
Metformin: an Old Therapy that Deserves a New Indication for the Treatment of ObesityQ38737909
Metformin: A Hopeful Promise in Aging ResearchQ38756907
Investing in Health to Create a Third Demographic DividendQ38781327
Role of oxidative stress in Alzheimer's diseaseQ38819665
Neuroinflammation in Alzheimer's disease: Current evidence and future directionsQ38834651
Oxidative stress, protein modification and Alzheimer diseaseQ38868767
Defining Rehabilitation Success in Older Adults with Dementia--Results from an Inpatient Geriatric Rehabilitation UnitQ39901920
Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult RatsQ40135757
Methods for Vascular Access and Collection of Body Fluids from the Laboratory RatQ40151522
Antidiabetic drugs restore abnormal transport of amyloid-β across the blood-brain barrier and memory impairment in db/db miceQ40695283
Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes.Q41841220
A glutamate dehydrogenase-based method for the assay of L-glutamic acid: formation of pyridine nucleotide fluorescent derivativesQ42020888
Morris water maze test for learning and memory deficits in Alzheimer's disease model miceQ42153622
Neuronal expression of GFAP in patients with Alzheimer pathology and identification of novel GFAP splice formsQ44557854
Inflammation and the redox-sensitive AGE-RAGE pathway as a therapeutic target in Alzheimer's diseaseQ46617604
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptidesQ47349499
Saxagliptin: a dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease.Q47895598
Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenaseQ47903414
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetesQ48157980
A central role for astrocytes in the inflammatory response to beta-amyloid; chemokines, cytokines and reactive oxygen species are producedQ48179910
Neuroprotective effects of ginseng protein on PI3K/Akt signaling pathway in the hippocampus of D-galactose/AlCl3 inducing rats model of Alzheimer's diseaseQ49066628
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmetforminQ19484
dementiaQ83030
insulin resistanceQ1053470
P304page(s)e0183565
P577publication date2017-08-23
P1433published inPLOS OneQ564954
P1476titleInvolvement of insulin resistance in D-galactose-induced age-related dementia in rats: Protective role of metformin and saxagliptin
P478volume12

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cites work (P2860)
Q60047498A Ketogenic Diet Improves Cognition and Has Biochemical Effects in Prefrontal Cortex That Are Dissociable From Hippocampus
Q91650986Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin
Q64091586Antidiabetic treatment on memory and spatial learning: From the pancreas to the neuron
Q64110048Combination of chick embryo and nutrient mixture prevent D-galactose-induced cognitive deficits, immune impairment and oxidative stress in aging rat model
Q91810119Escitalopram Ameliorates Cognitive Impairment in D-Galactose-Injected Ovariectomized Rats: Modulation of JNK, GSK-3β, and ERK Signalling Pathways
Q89446735Metformin and trimetazidine ameliorate diabetes-induced cognitive impediment in status epileptic rats
Q92693018Naringenin protects AlCl3/D-galactose induced neurotoxicity in rat model of AD via attenuation of acetylcholinesterase levels and inhibition of oxidative stress
Q60932964Pathogenic Feed-Forward Mechanisms in Alzheimer's and Parkinson's Disease Converge on GSK-3

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