Cidofovir Activity against Poxvirus Infections

scientific article

Cidofovir Activity against Poxvirus Infections is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3390/V2122803
P932PMC publication ID3185586
P698PubMed publication ID21994641
P5875ResearchGate publication ID51711972

P50authorRobert SnoeckQ47921736
Graciela AndreiQ47921752
P2860cites workTreatment with intravenous (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine of acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with AIDS.Q45780404
Activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) against guinea pig cytomegalovirus infection in cultured cells and in guinea pigsQ46223611
Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosineQ46492680
Severe eczema vaccinatum in a household contact of a smallpox vaccineeQ46639360
Cowpox infection transmitted from a domestic cat.Q46804034
Pharmacokinetics of cidofovir in renal insufficiency and in continuous ambulatory peritoneal dialysis or high-flux hemodialysisQ46860962
Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)-cytosine and 9-(1,3-dihydroxy-2-propoxymethyl)-guanine in the treatment of intracerebral murine cytomegalovirus infections in immunocompetent and immunodeficient miceQ48312954
Topical and intralesional cidofovir: a review of pharmacology and therapeutic effects.Q54117357
SmallpoxQ60060914
Kinetic analysis of the interaction of cidofovir diphosphate with human cytomegalovirus DNA polymeraseQ71077818
CidofovirQ71615638
Metabolic diversity and antiviral activities of acyclic nucleoside phosphonatesQ72173262
Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gammaQ72871557
Topical cidofovir for molluscum contagiosum in childrenQ73337514
Bioavailability and metabolism of cidofovir following topical administration to rabbitsQ73497838
Topical cidofovir for severe cutaneous human papillomavirus and molluscum contagiosum infections in patients with HIV/AIDS. A pilot studyQ74159968
Topical cidofovir for severe molluscum contagiosumQ77904834
Dramatic rescue relieves rare case of smallpox infectionQ80265175
Transmission of monkeypox among persons exposed to infected prairie dogs in Indiana in 2003Q23909258
Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphateQ24530586
Cellular uptake of phosphonylmethoxyalkylpurine derivativesQ28325396
Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongationQ28379498
Efficacy of Multiple- or Single-Dose Cidofovir against Vaccinia and Cowpox Virus Infections in MiceQ28396760
Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infectionQ30231576
The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.Q30759685
Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine].Q32084536
Cidofovir: a review of its use in cytomegalovirus retinitis in patients with AIDS.Q33726237
Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitroQ33804593
Clinical uses of cidofovirQ33867391
Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.Q33892331
Characterization of wild-type and cidofovir-resistant strains of camelpox, cowpox, monkeypox, and vaccinia virusesQ34107597
Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitroQ34111476
Cidofovir in the treatment of poxvirus infectionsQ34134474
Efficacy of cidofovir in a murine model of disseminated progressive vacciniaQ34140816
A review of topical and intralesional cidofovirQ34236016
Acyclic nucleoside phosphonates: a key class of antiviral drugsQ34464655
A case of human orf in an immunocompromised patient treated successfully with cidofovir creamQ34516537
Antiviral activity of HPMPC (cidofovir) against orf virus infected lambsQ34571871
Qualitative assessment of risk for monkeypox associated with domestic trade in certain animal species, United StatesQ34576518
Therapeutic paint of cidofovir/sucralfate gel combination topically administered by spraying for treatment of orf virus infectionsQ34606754
Role of cidofovir in the treatment of DNA virus infections, other than CMV infections, in immunocompromised patients.Q35023111
In vitro activity of potential anti-poxvirus agentsQ35077243
A review of compounds exhibiting anti-orthopoxvirus activity in animal modelsQ35077248
Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.Q35103702
Anticytomegaloviral activity and safety of cidofovir in patients with human immunodeficiency virus infection and cytomegalovirus viruriaQ35113383
Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patientsQ35115039
Mutations in the E9L polymerase gene of cidofovir-resistant vaccinia virus strain WR are associated with the drug resistance phenotypeQ35215440
Oral treatment of cowpox and vaccinia virus infections in mice with ether lipid esters of cidofovir.Q35547866
Clinical Potential of the Acyclic Nucleoside Phosphonates Cidofovir, Adefovir, and Tenofovir in Treatment of DNA Virus and Retrovirus InfectionsQ35558801
Human monkeypox: an emerging zoonosisQ35628219
Aerosolized cidofovir is retained in the respiratory tract and protects mice against intranasal cowpox virus challengeQ35685188
Differential pathogenesis of cowpox virus intranasal infections in mice induced by low and high inoculum volumes and effects of cidofovir treatmentQ36631850
Isolation and characterization of cidofovir resistant vaccinia virusesQ36678276
Coadministration of cidofovir and smallpox vaccine reduced vaccination side effects but interfered with vaccine-elicited immune responses and immunity to monkeypoxQ37033408
Cowpox virus infection: an emerging health threatQ37100940
The 3'-to-5' exonuclease activity of vaccinia virus DNA polymerase is essential and plays a role in promoting virus genetic recombinationQ37157260
Cowpox virus transmission from pet rats to humans, FranceQ37203679
Cowpox virus transmission from pet rats to humans, GermanyQ37203719
Progress in the discovery of compounds inhibiting orthopoxviruses in animal modelsQ37331541
Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: current state of the art.Q37401749
Oral treatment of murine cytomegalovirus infections with ether lipid esters of cidofovirQ37488882
Inhibitory activity of alkoxyalkyl and alkyl esters of cidofovir and cyclic cidofovir against orthopoxvirus replication in vitroQ37734396
Biochemical pharmacology of acyclic nucleotide analoguesQ37783046
Efficacy of therapeutic intervention with an oral ether-lipid analogue of cidofovir (CMX001) in a lethal mousepox modelQ38460330
Design and development of oral drugs for the prophylaxis and treatment of smallpox infection.Q38477864
Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney.Q38482641
Cidofovir resistance in vaccinia virus is linked to diminished virulence in miceQ38760673
Cidofovir inhibits genome encapsidation and affects morphogenesis during the replication of vaccinia virusQ39804417
Inhibition of vaccinia virus replication by two small interfering RNAs targeting B1R and G7L genes and their synergistic combination with cidofovirQ39869286
Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activityQ40065243
Renal transport of adefovir, cidofovir, and tenofovir by SLC22A family members (hOAT1, hOAT3, and hOCT2).Q40156820
Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compoundsQ40171474
Enhanced antiproliferative effects of alkoxyalkyl esters of cidofovir in human cervical cancer cells in vitroQ40325993
Activities of acyclic nucleoside phosphonates against Orf virus in human and ovine cell monolayers and organotypic ovine raft culturesQ40348369
Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidinesQ40358241
Synthesis and antiviral activity of 2,4-diamino-5-cyano-6-[2-(phosphonomethoxy)ethoxy]pyrimidine and related compoundsQ40552798
5-Substituted-2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidines-acyclic nucleoside phosphonate analogues with antiviral activityQ40621753
Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infectionsQ40666918
A novel selective broad-spectrum anti-DNA virus agentQ40804246
Parapoxviruses are strongly inhibited in vitro by cidofovirQ40829323
Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host cellsQ41148686
Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidinesQ41270617
Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirusQ41343033
Mechanism of antiviral drug resistance of vaccinia virus: identification of residues in the viral DNA polymerase conferring differential resistance to antipoxvirus drugsQ41361126
Cidofovir and (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine are highly effective inhibitors of vaccinia virus DNA polymerase when incorporated into the template strandQ41915115
Human cowpox in a veterinary studentQ43119827
Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro.Q43261185
Treatment of aerosolized cowpox virus infection in mice with aerosolized cidofovirQ43485506
Phase II double-blind, placebo-controlled study of the safety and efficacy of cidofovir topical gel for the treatment of patients with human papillomavirus infectionQ43690814
Topical cidofovir is more effective than is parenteral therapy for treatment of progressive vaccinia in immunocompromised miceQ43719348
Human renal organic anion transporter 1 (hOAT1) and its role in the nephrotoxicity of antiviral nucleotide analogsQ43741891
Topical use of cidofovir induced acute renal failureQ43914181
Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrugQ44025971
Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in Vero cellsQ44164228
Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.Q44329265
Comparative effects of cidofovir and cyclic HPMPC on lethal cowpox and vaccinia virus respiratory infections in miceQ44483465
Activity of the anti-orthopoxvirus compound ST-246 against vaccinia, cowpox and camelpox viruses in cell monolayers and organotypic raft culturesQ44594293
(S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine (cidofovir): results of a phase I/II study of a novel antiviral nucleotide analogueQ44677601
Intralesional cidofovir and surgical excision for laryngeal papillomatosisQ44683735
Disseminated vaccinia in a military recruit with human immunodeficiency virus (HIV) diseaseQ44718436
Topical cidofovir and cryotherapy--combination treatment for recalcitrant molluscum contagiosum in a patient with HIV infectionQ44792068
A 17-year-old girl with a black eschar. Cowpox virus infectionQ44840225
Cutaneous infections of mice with vaccinia or cowpox viruses and efficacy of cidofovirQ44936207
Cidofovir plasma assays after local injection in respiratory papillomatosisQ44964837
Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection.Q44970891
Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitroQ45212219
Cidofovir diphosphate inhibits molluscum contagiosum virus DNA polymerase activityQ45399247
In vivo imaging of cidofovir treatment of cowpox virus infection.Q45403628
Progressive ORF virus infection in a patient with lymphoma: successful treatment using imiquimodQ45404387
Effects of cidofovir treatment on cytokine induction in murine models of cowpox and vaccinia virus infectionQ45415555
The efficacy of cidofovir treatment of mice infected with ectromelia (mousepox) virus encoding interleukin-4.Q45493777
Intranasal treatment of cowpox virus respiratory infections in mice with cidofovirQ45740776
Topical cidofovir: a novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus 1.Q45741202
Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challengeQ45745500
Resolution of recalcitrant molluscum contagiosum virus lesions in human immunodeficiency virus-infected patients treated with cidofovirQ45761008
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue12
P304page(s)2803-2830
P577publication date2010-12-22
P1433published inVirusesQ7935305
P1476titleCidofovir Activity against Poxvirus Infections
P478volume2

Reverse relations

cites work (P2860)
Q44205846Autoinoculation with Orf virus (ecthyma contagiosum).
Q47547852Challenges and Achievements in Prevention and Treatment of Smallpox
Q47558565Disaster Preparedness: Biological Threats and Treatment Options
Q34606386Emergence of cowpox: study of the virulence of clinical strains and evaluation of antivirals
Q37544535KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo
Q37173398Orthopoxvirus targets for the development of new antiviral agents.
Q28294254Poxvirus DNA replication
Q37539293Serro 2 Virus Highlights the Fundamental Genomic and Biological Features of a Natural Vaccinia Virus Infecting Humans
Q47107948Suppression of Poxvirus Replication by Resveratrol
Q39118775The vaccinia virus DNA polymerase and its processivity factor
Q38797660Treatment of CMV infection after allogeneic hematopoietic stem cell transplantation.

Search more.