The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases

scientific article published on 02 April 2008

The hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M709921200
P932PMC publication ID2397479
P698PubMed publication ID18387958

P2093author name stringPaul H Weigel
Edward N Harris
Svetlana V Kyosseva
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Stabilin-1 and -2 constitute a novel family of fasciclin-like hyaluronan receptor homologuesQ24533666
The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cellsQ24595836
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“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein AQ28131712
The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progressionQ28266918
Specificity and mechanism of action of some commonly used protein kinase inhibitorsQ28344791
Molecular cloning and functional expression of the rat 175-kDa hyaluronan receptor for endocytosisQ28579566
Hyaluronan and its binding proteins, the hyaladherinsQ28610932
Endocytosis and molecular sortingQ29616706
Purification and molecular identification of the human hyaluronan receptor for endocytosisQ33186314
Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharidesQ33209764
Hyaluronan: a multifunctional, megaDalton, stealth moleculeQ34026287
Hyaluronan-binding proteins: tying up the giantQ34102666
Hyaluronan in morphogenesisQ34211756
Signaling on the endocytic pathwayQ34271908
Endocytic function, glycosaminoglycan specificity, and antibody sensitivity of the recombinant human 190-kDa hyaluronan receptor for endocytosis (HARE).Q34328047
Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand bindingQ34372299
Signaling properties of hyaluronan receptorsQ34444928
Expression, processing, and glycosaminoglycan binding activity of the recombinant human 315-kDa hyaluronic acid receptor for endocytosis (HARE).Q34587232
Glycans as endocytosis signals: the cases of the asialoglycoprotein and hyaluronan/chondroitin sulfate receptorsQ34838026
Hyaluronan--magic glue for the regulation of the immune response?Q35077136
Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytesQ35113980
Mitogen-activated protein kinase signalingQ35684709
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expressionQ35688212
Hyaluronan: from extracellular glue to pericellular cue.Q35824079
Intracellular hyaluronan: a new frontier for inflammation?Q35828207
HyaluronanQ36001372
Hyaluronan fragments: an information-rich systemQ36528068
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.Q37105461
Purification and subunit characterization of the rat liver endocytic hyaluronan receptorQ38318298
Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migrationQ40134433
Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.Q40470094
CD44 signaling through focal adhesion kinase and its anti-apoptotic effectQ40701709
Hyaluronate-enhanced hematopoiesis: two different receptors trigger the release of interleukin-1beta and interleukin-6 from bone marrow macrophages.Q40939709
The hyaluronan receptor RHAMM regulates extracellular-regulated kinaseQ41036869
HA receptors: regulators of signalling to the cytoskeletonQ41111718
Serum hyaluronan as a disease markerQ41114766
Endocytosis of hyaluronic acid by rat liver endothelial cells. Evidence for receptor recyclingQ42821304
A blocking antibody to the hyaluronan receptor for endocytosis (HARE) inhibits hyaluronan clearance by perfused liverQ44367842
Expression of stabilin-2, a novel fasciclin-like hyaluronan receptor protein, in murine sinusoidal endothelia, avascular tissues, and at solid/liquid interfacesQ44642404
Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: comparison between invasive and non-invasive areasQ44798703
Hyaluronan in the bovine oviduct--modulation of synthases and receptors during the estrous cycle.Q44828428
Selective activation of the MEK-ERK pathway is regulated by mechanical stimuli in forming joints and promotes pericellular matrix formationQ45221658
Tissue uptake of circulating hyaluronic acid. A whole body autoradiographic study.Q54505936
Morphological studies on endocytosis of chondroitin sulphate proteoglycan by rat liver endothelial cellsQ68502661
The production of hyaluronate by spontaneously established cell lines and viral transformed lines of fibroblastic originQ68556068
Preparation of alkylamine and 125I-radiolabeled derivatives of hyaluronic acid uniquely modified at the reducing endQ71416840
The rat hepatic lectin 1 subunit of the rat asialoglycoprotein receptor is a phosphoprotein and contains phosphotyrosineQ71665557
High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancerQ73383737
Identification of the hyaluronan receptor for endocytosis (HARE)Q74206408
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)15047-15055
P577publication date2008-04-02
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe hyaluronan receptor for endocytosis mediates hyaluronan-dependent signal transduction via extracellular signal-regulated kinases
P478volume283

Reverse relations

cites work (P2860)
Q887898913-O sulfation of heparin leads to hepatotropism and longer circulatory half-life
Q34070308A hyaluronan receptor for endocytosis (HARE) link domain N-glycan is required for extracellular signal-regulated kinase (ERK) and nuclear factor-κB (NF-κB) signaling in response to the uptake of hyaluronan but not heparin, dermatan sulfate, or acety
Q37251751Abundance and location of proteoglycans and hyaluronan within normal and myxomatous mitral valves
Q35995906Activation of ERK and NF-κB during HARE-Mediated Heparin Uptake Require Only One of the Four Endocytic Motifs
Q34556913Antifibrotic effect of MMP13-encoding plasmid DNA delivered using polyethylenimine shielded with hyaluronic acid
Q50044576Endosomal Escape of ASOs Internalized by Stabilin Receptors Is Regulated by Rab5C and EEA1 During Endosomal Maturation
Q35324915HARE-Mediated Endocytosis of Hyaluronan and Heparin Is Targeted by Different Subsets of Three Endocytic Motifs
Q36286091Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis
Q47279374Hyaluronan synthase control of synthesis rate and hyaluronan product size are independent functions differentially affected by mutations in a conserved tandem B-X7-B motif
Q35106180Hyaluronic acid receptor Stabilin-2 regulates Erk phosphorylation and arterial--venous differentiation in zebrafish
Q37488558Hyaluronic acid receptor for endocytosis (HARE)-mediated endocytosis of hyaluronan, heparin, dermatan sulfate, and acetylated low density lipoprotein (AcLDL), but not chondroitin sulfate types A, C, D, or E, activates NF-κB-regulated gene expression
Q92127657Ligand Binding and Signaling of HARE/Stabilin-2
Q33955772N-Glycans on the link domain of human HARE/Stabilin-2 are needed for hyaluronan binding to purified ecto-domain, but not for cellular endocytosis of hyaluronan
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Q41177184The cytoplasmic domain of the hyaluronan receptor for endocytosis (HARE) contains multiple endocytic motifs targeting coated pit-mediated internalization
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Q36850223The hyaluronan receptor for endocytosis (HARE) activates NF-κB-mediated gene expression in response to 40-400-kDa, but not smaller or larger, hyaluronans
Q36922376The ligand-binding profile of HARE: hyaluronan and chondroitin sulfates A, C, and D bind to overlapping sites distinct from the sites for heparin, acetylated low-density lipoprotein, dermatan sulfate, and CS-E.
Q34772053Tissue-specific splice variants of HARE/Stabilin-2 are expressed in bone marrow, lymph node, and spleen
Q42406891Tumor-exosomes and leukocyte activation: an ambivalent crosstalk

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