Statistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals

scientific article published on 08 August 2017

Statistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1091025256
P356DOI10.1038/S41598-017-06106-1
P932PMC publication ID5548860
P698PubMed publication ID28790338

P50authorJiankui HeQ59223278
Zhoufang LiQ100695175
P2093author name stringGeng Tian
Xiaohua Li
Bo Zhou
Fang Deng
Chaoyu Liu
Shixin Lu
Ligang Xia
Weiren Huang
Yuancai Xie
Hongyu Dai
Feiyue Xu
Xiaonian Tu
Lidong Zeng
P2860cites workExtensive Variation in the Mutation Rate Between and Within Human Genes Associated with Mendelian Disease.Q50717100
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ctDNA is a specific and sensitive biomarker in multiple human cancersQ87625205
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Estimate of the mutation rate per nucleotide in humansQ24548130
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Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesisQ28386212
Time-to-Progression of NSCLC from Early to Advanced Stages: An Analysis of data from SEER Registry and a Single InstituteQ31110762
Landscape of somatic mutations in 560 breast cancer whole-genome sequencesQ34046731
Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genesQ34356721
Integrated digital error suppression for improved detection of circulating tumor DNAQ34520008
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skinQ35752935
Circulating tumor cells (Ctc) and kras mutant circulating free Dna (cfdna) detection in peripheral blood as biomarkers in patients diagnosed with exocrine pancreatic cancerQ35820329
Individualized Mutation Detection in Circulating Tumor DNA for Monitoring Colorectal Tumor Burden Using a Cancer-Associated Gene Sequencing PanelQ35884196
Circulating nucleic acids in plasma and serum (CNAPS): applications in oncologyQ37014663
ctDNA dynamics: a novel indicator to track resistance in metastatic breast cancer treated with anti-HER2 therapyQ37662351
Enumeration and targeted analysis of KRAS, BRAF and PIK3CA mutations in CTCs captured by a label-free platform: Comparison to ctDNA and tissue in metastatic colorectal cancerQ37709148
Next generation sequencing reveals genetic landscape of hepatocellular carcinomasQ38051922
Cell-free DNA (cfDNA): Clinical Significance and Utility in Cancer Shaped By Emerging TechnologiesQ38390077
Genomic complexity of urothelial bladder cancer revealed in urinary cfDNA.Q40116927
Breast cancer: Tracking ctDNA to evaluate relapse risk.Q48651745
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectstatisticsQ12483
P304page(s)7526
P577publication date2017-08-08
P1433published inScientific ReportsQ2261792
P1476titleStatistical analysis of mutant allele frequency level of circulating cell-free DNA and blood cells in healthy individuals
P478volume7

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cites work (P2860)
Q93122680Life and death of circulating cell-free DNA
Q49740946Liquid Biopsy in Clinical Management of Breast, Lung, and Colorectal Cancer
Q92767070Mutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis
Q90331376Noninvasive cancer biomarkers in solid malignancies: circulating tumor DNA-clinical utility, current limitations and future perspectives
Q93077051Resectable lung lesions malignancy assessment and cancer detection by ultra-deep sequencing of targeted gene mutations in plasma cell-free DNA
Q92721586Single-molecule detection of cancer mutations using a novel PCR-LDR-qPCR assay
Q89525803The potential of combined mutation sequencing of plasma circulating cell-free DNA and matched white blood cells for treatment response prediction
Q90884383eVIDENCE: a practical variant filtering for low-frequency variants detection in cell-free DNA

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