Biological Networks Governing the Acquisition, Maintenance, and Dissolution of Pluripotency: Insights from Functional Genomics Approaches

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Biological Networks Governing the Acquisition, Maintenance, and Dissolution of Pluripotency: Insights from Functional Genomics Approaches is …
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scholarly articleQ13442814

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P356DOI10.1101/SQB.2015.80.027326
P698PubMed publication ID26582790

P50authorKevin Andrew Uy GonzalesQ84489251
Huck Hui NgQ42691422
P2093author name stringKevin Andrew Uy Gonzales
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RNA-guided human genome engineering via Cas9Q24598394
Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3Q24600230
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Derivation of novel human ground state naive pluripotent stem cellsQ46977037
Vascularized and functional human liver from an iPSC-derived organ bud transplantQ48453997
A Direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regenerationQ51071233
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
Mutations affecting segment number and polarity in DrosophilaQ28273492
Dissecting self-renewal in stem cells with RNA interferenceQ28506922
Genetic exploration of the exit from self-renewal using haploid embryonic stem cellsQ28587174
Exit from Pluripotency Is Gated by Intracellular Redistribution of the bHLH Transcription Factor Tfe3Q28594750
Cerebral organoids model human brain development and microcephalyQ28973619
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modificationQ29029259
The ground state of embryonic stem cell self-renewalQ29547196
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3Q29614624
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New cell lines from mouse epiblast share defining features with human embryonic stem cellsQ29614820
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DNA targeting specificity of RNA-guided Cas9 nucleasesQ29615793
Improving CRISPR-Cas nuclease specificity using truncated guide RNAsQ29616043
Genome-scale CRISPR-Cas9 knockout screening in human cellsQ29616044
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cellsQ29616045
Naive and primed pluripotent statesQ29616638
Genetic screens in human cells using the CRISPR-Cas9 systemQ29617411
Derivation of Embryonic Stem-Cell Lines from Human BlastocystsQ29999326
Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease.Q30458169
A kinase inhibitor screen identifies small-molecule enhancers of reprogramming and iPS cell generation.Q30539955
Genetic screens in mammalian cells by enhanced retroviral mutagensQ30645249
High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cellsQ33340187
Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotencyQ33529565
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Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma modelQ33693027
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editingQ33875102
A PiggyBac-Based Recessive Screening Method to Identify Pluripotency RegulatorsQ33886516
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complexQ34042665
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The art and design of genetic screens: zebrafishQ34104121
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency.Q34107595
Genome-wide functional analysis reveals factors needed at the transition steps of induced reprogramming.Q34122283
The art and design of genetic screens: Drosophila melanogasterQ34125137
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogrammingQ34125369
The art and design of genetic screens: caenorhabditis elegansQ34126620
Resetting transcription factor control circuitry toward ground-state pluripotency in humanQ34173263
Quantitative optical imaging of primary tumor organoid metabolism predicts drug response in breast cancer.Q34205196
A genome-wide RNAi screen identifies opposing functions of Snai1 and Snai2 on the Nanog dependency in reprogrammingQ34287955
Systematic identification of culture conditions for induction and maintenance of naive human pluripotencyQ34288016
An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancerQ34345765
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Genome-Scale CRISPR-Mediated Control of Gene Repression and ActivationQ34443093
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A genome-wide RNAi screen reveals MAP kinase phosphatases as key ERK pathway regulators during embryonic stem cell differentiation.Q34524686
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA libraryQ35096218
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growthQ35173269
In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.Q35250612
piggyBac insertional mutagenesis screen identifies a role for nuclear RHOA in human ES cell differentiationQ35623836
A genome-wide RNAi screen in mouse embryonic stem cells identifies Mp1 as a key mediator of differentiation.Q35627696
CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library.Q35689038
Origin and evolution of high throughput screeningQ35995255
Systematic identification of factors for provirus silencing in embryonic stem cellsQ36390458
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouseQ36512789
Regulation of pluripotency and cellular reprogramming by the ubiquitin-proteasome systemQ36547551
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.Q36791239
RNAi screens in mice identify physiological regulators of oncogenic growthQ37174807
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases.Q37420333
Derivation of naive human embryonic stem cells.Q37674318
Systematic identification of barriers to human iPSC generationQ38305710
Prospective derivation of a living organoid biobank of colorectal cancer patients.Q38877277
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast.Q39046785
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells.Q39181191
A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.Q39643148
Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cellsQ39794349
Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent CellsQ39803761
Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cellsQ39997700
Basic fibroblast growth factor supports undifferentiated human embryonic stem cell growth without conditioned medium.Q40450001
Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways.Q40671579
An RNAi screen of chromatin proteins identifies Tip60-p400 as a regulator of embryonic stem cell identity.Q42151370
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomasQ42870965
A genome-wide RNAi screen identifies a new transcriptional module required for self-renewalQ43148740
Activin A maintains pluripotency of human embryonic stem cells in the absence of feeder layersQ46404347
P921main subjectfunctional genomicsQ1068690
pluripotencyQ1894941
P304page(s)189-198
P577publication date2015-11-18
P1433published inCold Spring Harbor Symposia on Quantitative BiologyQ15758412
P1476titleBiological Networks Governing the Acquisition, Maintenance, and Dissolution of Pluripotency: Insights from Functional Genomics Approaches
P478volume80

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Q92616891Inter-genus gene expression analysis in livestock fibroblasts using reference gene validation based upon a multi-species primer setcites workP2860

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