The role of oxysterols in vascular ageing.

scientific article

The role of oxysterols in vascular ageing. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JP271168
P932PMC publication ID4933108
P698PubMed publication ID26648329

P50authorGabriella TestaQ83310717
Paola GambaQ58954690
Gabriella LeonarduzziQ58954705
P2093author name stringGiuseppe Poli
Simona Gargiulo
P2860cites workRelative contribution of individual oxidized components in ox-LDL to inhibition on endothelium-dependent relaxation in rat aortaQ82222626
Arterial tissue and plasma concentration of enzymatic-driven oxysterols are associated with severe peripheral atherosclerotic disease and systemic inflammatory activityQ86166137
Oxidized low-density lipoprotein increases the proliferation and migration of human coronary artery smooth muscle cells through the upregulation of osteopontinQ95560918
NAD(P)H oxidase Nox-4 mediates 7-ketocholesterol-induced endoplasmic reticulum stress and apoptosis in human aortic smooth muscle cellsQ24559719
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Increased mitochondrial oxidative stress in the Sod2 (+/-) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosisQ28587044
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Fast LC-MS/MS analysis of free oxysterols derived from reactive oxygen species in human plasma and carotid plaqueQ33458531
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TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify.Q34145009
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Oxidized low-density lipoproteinQ35860737
The role of oxysterols in control of endothelial stiffnessQ36020280
Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesionQ36095658
Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion moleculesQ46432121
7-ketocholesterol, a major oxysterol, promotes pi-induced vascular calcification in cultured smooth muscle cellsQ46499797
TNF-alpha activates death pathway in human aorta smooth muscle cell in the presence of 7-ketocholesterolQ46579373
Phospholipidosis and down-regulation of the PI3-K/PDK-1/Akt signalling pathway are vitamin E inhibitable events associated with 7-ketocholesterol-induced apoptosis.Q46582802
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Mechanisms of selenium inhibition of cell apoptosis induced by oxysterols in rat vascular smooth muscle cellsQ46615468
Oxidation as a crucial reaction for cholesterol to induce tissue degeneration: CD36 overexpression in human promonocytic cells treated with a biologically relevant oxysterol mixture.Q46709404
Redox regulation of 4-hydroxy-2-nonenal-mediated endothelial barrier dysfunction by focal adhesion, adherens, and tight junction proteinsQ48418506
Oxysterol-induced apoptosis of smooth muscle cells is under the control of a soluble adenylyl cyclase.Q50942948
Multiplexed flow cytometric analyses of pro- and anti-inflammatory cytokines in the culture media of oxysterol-treated human monocytic cells and in the sera of atherosclerotic patients.Q51229793
Expression of Egr1 and p53 in human carotid plaques and apoptosis induced by 7-oxysterol or p53.Q53143917
Purmorphamine and oxysterols accelerate and promote osteogenic differentiation of mesenchymal stem cells in vitro.Q53287130
p53 expression in human carotid atheroma is significantly related to plaque instability and clinical manifestations.Q53349571
Oxidized low-density lipoprotein increases bone sialoprotein expression in vascular smooth muscle cells via runt-related transcription factor 2.Q54180489
Endothelial Protection, AT1 Blockade and Cholesterol-Dependent Oxidative Stress: The EPAS TrialQ60734598
Effect of cholesterol oxides on prostacyclin production and platelet adhesionQ72606933
Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins. Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxationQ73047649
Apoptosis regulates human vascular calcification in vitro: evidence for initiation of vascular calcification by apoptotic bodiesQ73221508
25-Hydroxycholesterol activates a cytochrome c release-mediated caspase cascadeQ73235462
25-hydroxycholesterol increases eicosanoids and alters morphology in cultured pulmonary artery smooth muscle and endothelial cellsQ73257365
Inhibition by cholesterol oxides of NO release from human vascular endothelial cellsQ74794160
Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species productionQ77630779
Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterolQ77746442
Low-density lipoproteins induce the renin-angiotensin system and their receptors in human endothelial cellsQ81575302
Lipid accumulation and lysosomal pathways contribute to dysfunction and apoptosis of human endothelial cells caused by 7-oxysterolsQ39534529
7beta-Hydroxycholesterol and 25-hydroxycholesterol-induced interleukin-8 secretion involves a calcium-dependent activation of c-fos via the ERK1/2 signaling pathway in THP-1 cells: oxysterols-induced IL-8 secretion is calcium-dependentQ40006045
Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cellsQ40363965
Oral alpha-tocopherol supplementation inhibits lipid oxidation in established human atherosclerotic lesions.Q40540239
Oxysterols regulate differentiation of mesenchymal stem cells: pro-bone and anti-fatQ40569483
Generation of an oxidative stress precedes caspase activation during 7beta-hydroxycholesterol-induced apoptosis in U937 cellsQ40583392
Oxysterols induce apoptosis and accumulation of cell cycle at G(2)/M phase in the human monocytic THP-1 cell lineQ40677748
Oxysterol activators of liver X receptor and 9-cis-retinoic acid promote sequential steps in the synthesis and secretion of tumor necrosis factor-alpha from human monocytesQ40763763
Oxysterol-induced endothelial cell dysfunction in cultureQ41086973
7-Ketocholesterol and 5,6-secosterol induce human endothelial cell dysfunction by differential mechanisms.Q41389623
Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3).Q41433246
27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharideQ41604856
Mitochondrial function contributes to oxysterol-induced osteogenic differentiation in mouse embryonic stem cellsQ41671202
Endothelial function and oxidant stress.Q41677781
Molecular signaling involved in oxysterol-induced β₁-integrin over-expression in human macrophages.Q42111774
7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophagesQ42265578
Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescenceQ42272254
Increased expression of matrix metalloproteinase-2 in the thickened intima of aged ratsQ42467432
7-ketocholesterol inhibits Na,K-ATPase activity by decreasing expression of its α1-subunit and membrane fluidity in human endothelial cells.Q42479647
Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanismQ42821910
Proinflammatory effect of cholesterol and its oxidation products on CaCo-2 human enterocyte-like cells: effective protection by epigallocatechin-3-gallate.Q42869311
Oxidative stress and endothelial dysfunction in aortas of aged spontaneously hypertensive rats by NOX1/2 is reversed by NADPH oxidase inhibitionQ42981880
7-Ketocholesterol and cholesterol-5alpha,6alpha-epoxide induce smooth muscle cell migration and proliferation through the epidermal growth factor receptor/phosphoinositide 3-kinase/Akt signaling pathwaysQ43064474
Molecular signaling operated by a diet-compatible mixture of oxysterols in up-regulating CD36 receptor in CD68 positive cellsQ43120227
Pro-oxidant and proapoptotic effects of cholesterol oxidation products on human colonic epithelial cells: a potential mechanism of inflammatory bowel disease progressionQ43271871
Selective distribution of oxysterols in atherosclerotic lesions and human plasma lipoproteinsQ43621649
Up-regulation of the fibrogenic cytokine TGF-beta1 by oxysterols: a mechanistic link between cholesterol and atherosclerosis.Q43654469
Interaction of caveolin with 7-ketocholesterolQ43786545
Oxysterol profiles of normal human arteries, fatty streaks and advanced lesionsQ43791108
Dietary cholesterol oxidation products accelerate plaque destabilization and rupture associated with monocyte infiltration/activation via the MCP-1-CCR2 pathway in mouse brachiocephalic arteries: therapeutic effects of ezetimibe.Q43996274
Measurement of oxysterols and alpha-tocopherol in plasma and tissue samples as indices of oxidant stress status.Q44280509
Vitamin E supplementation in patients with carotid atherosclerosis: reversal of altered oxidative stress status in plasma but not in plaqueQ44639029
Cholesterol-3-beta, 5-alpha, 6-beta-triol induced genotoxicity through reactive oxygen species formation.Q45274192
Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemiaQ45871892
Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterolsQ46167808
Nitric oxide is the mediator of both endothelium-dependent relaxation and hyperpolarization of the rabbit carotid artery.Q36111652
Vascular endothelium and blood flow.Q36603028
Aging: a revisited theory based on free radicals generated by NOX family NADPH oxidasesQ36663405
Activation of the mitochondrial pathway of apoptosis by oxysterolsQ36664440
Endothelial function and dysfunction: testing and clinical relevanceQ36758044
The reality of aging viewed from the arterial wallQ36823269
Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigrationQ36957712
Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNEQ37107499
Cellular signaling and NO productionQ37173867
Cholesterol oxidation products and disease: an emerging topic of interest in medicinal chemistry.Q37387429
Cholesterol oxidation products in the vascular remodeling due to atherosclerosis.Q37402920
Oxysterols and mechanisms of apoptotic signaling: implications in the pathology of degenerative diseasesQ37432832
Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5.Q37805535
Inflammation-related gene expression by lipid oxidation-derived products in the progression of atherosclerosis.Q37950827
Molecular mechanisms of hypertension--reactive oxygen species and antioxidants: a basic science update for the clinicianQ37996665
Vascular ageing: the role of oxidative stress.Q38073022
Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosisQ38094613
The role of prostaglandin E2 in human vascular inflammationQ38113595
Oxysterols and symptomatic versus asymptomatic human atherosclerotic plaqueQ38176158
Angiotensin II and vascular injuryQ38206728
A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress.Q38239644
Nox family NADPH oxidases: Molecular mechanisms of activationQ38243365
Endothelial cell senescence and age-related vascular diseasesQ38255622
Involvement of oxysterols in age-related diseases and ageing processes.Q38259138
The Effect of Ageing on Vascular Smooth Muscle Cell Behaviour--A Mini-ReviewQ38282530
Imaging of cellular aging in human retinal blood vesselsQ38394371
Oxidized LDL (oxLDL) activates the angiotensin II type 1 receptor by binding to the lectin-like oxLDL receptorQ38886788
Relation between TLR4/NF-κB signaling pathway activation by 27-hydroxycholesterol and 4-hydroxynonenal, and atherosclerotic plaque instability.Q38901560
Survival signaling elicited by 27-hydroxycholesterol through the combined modulation of cellular redox state and ERK/Akt phosphorylationQ38967259
27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophagesQ39224829
Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line.Q39254387
Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependentQ39277101
Angiotensin AT1 receptor blockers suppress oxidized low-density lipoprotein-derived formation of foam cellsQ39408697
Plaque oxysterols induce unbalanced up-regulation of matrix metalloproteinase-9 in macrophagic cells through redox-sensitive signaling pathways: Implications regarding the vulnerability of atherosclerotic lesionsQ39526342
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2095-2113
P577publication date2016-01-19
P1433published inJournal of PhysiologyQ7743612
P1476titleThe role of oxysterols in vascular ageing
P478volume594

Reverse relations

cites work (P2860)
Q3878149127-Hydroxycholesterol accelerates cellular senescence in human lung resident cells.
Q41454286Aerobic Exercise Training Selectively Changes Oxysterol Levels and Metabolism Reducing Cholesterol Accumulation in the Aorta of Dyslipidemic Mice.
Q89181989Cardiovascular and skeletal muscle ageing: consequences for longevity
Q91929324Excessive early-life cholesterol exposure may have later-life consequences for nonalcoholic fatty liver disease
Q92477685The Effect of Effort Test on the Levels of Ischemia Modified Albumin, 7-ketocholesterol and Cholestan-3β , 5α , 6β -triol and their Role in the Diagnosis of Coronary Artery Disease
Q90396189The Protective Effect of Dabigatran and Rivaroxaban on DNA Oxidative Changes in a Model of Vascular Endothelial Damage with Oxidized Cholesterol

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