A Bright Future for Antibiotics?

scientific article

A Bright Future for Antibiotics? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1146/ANNUREV-BIOCHEM-061516-044617
P698PubMed publication ID28654325

P50authorAda YonathQ7426
Donna MatzovQ54687679
Anat BashanQ28027621
P2860cites workRibosomal protection proteins and their mechanism of tetracycline resistanceQ24628384
The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioningQ24652742
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Designing Safer and Greener AntibioticsQ27022324
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Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.Q27631119
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Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteriaQ27635569
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Structural Insight into the Antibiotic Action of Telithromycin against Resistant MutantsQ27641602
Presence of variations in ribosomal protein L16 corresponding to susceptibility of enterococci to oligosaccharides (Avilamycin and evernimicin).Q39475744
Multidrug-resistant Enterococcus faecium. An untreatable nosocomial pathogenQ40397051
The development of peptide ligands that target helix 69 rRNA of bacterial ribosomes.Q40588080
Mutations in the bacterial ribosomal protein l3 and their association with antibiotic resistance.Q40676510
Structural rearrangements of a polyketide synthase module during its catalytic cycleQ41456081
Structure of a modular polyketide synthaseQ41608053
A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanismQ41872353
Selective protein synthesis by ribosomes with a drug-obstructed exit tunnelQ44890226
Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulinQ45156906
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistanceQ46455040
Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus.Q46877406
Cryocrystallography of ribosomal particlesQ47584452
Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture).Q48307712
The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.Q50900973
Deregulation of translation due to post-transcriptional modification of rRNA explains why erm genes are inducible.Q50924008
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation.Q52930336
A tunnel in the large ribosomal subunit revealed by three-dimensional image reconstructionQ69004129
Where will new antibiotics come from?Q79817299
SnapShot: Antibiotic inhibition of protein synthesis IQ84574037
The Structures of Antibiotics Bound to the E Site Region of the 50 S Ribosomal Subunit of Haloarcula marismortui: 13-Deoxytedanolide and GirodazoleQ27643897
Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivityQ27644059
Structural basis for aminoglycoside inhibition of bacterial ribosome recyclingQ27646911
A Steric Block in Translation Caused by the Antibiotic SpectinomycinQ27647153
Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcinQ27650303
Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunitQ27650650
Structural basis for hygromycin B inhibition of protein biosynthesisQ27650910
The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibioticsQ27658997
The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosomeQ27659850
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug actionQ27664697
Revisiting the structures of several antibiotics bound to the bacterial ribosomeQ27664704
Crystal structure of the eukaryotic ribosomeQ27666069
Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunitQ27666800
Antibiotic resistance is ancientQ27672681
Structural basis for TetM-mediated tetracycline resistanceQ27673851
The structure of the eukaryotic ribosome at 3.0 Å resolutionQ27675638
Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)Q27676345
The Antibiotic Thermorubin Inhibits Protein Synthesis by Binding to Inter-Subunit Bridge B2a of the RibosomeQ27676704
A new understanding of the decoding principle on the ribosomeQ27678131
Identification of the molecular attributes required for aminoglycoside activity against LeishmaniaQ27679272
Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptideQ27682411
The bacterial ribosome as a target for antibioticsQ28279726
Antibiotics for emerging pathogensQ29615377
Origins and evolution of antibiotic resistanceQ29617791
Macrolide antibiotics allosterically predispose the ribosome for translation arrestQ30584257
Novel avilamycin derivatives with improved polarity generated by targeted gene disruptionQ30970624
Personalized Nutrition by Prediction of Glycemic Responses.Q33445995
Selection of small peptides, inhibitors of translationQ33478199
The antituberculosis antibiotic capreomycin inhibits protein synthesis by disrupting interaction between ribosomal proteins L12 and L10.Q33622886
The shared antibiotic resistome of soil bacteria and human pathogensQ33804392
Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.Q34049640
Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.Q34107147
Multidrug-resistant to extensively drug resistant tuberculosis: what is next?Q37390251
Regulation of gene expression by macrolide-induced ribosomal frameshiftingQ37418561
Long-term nonsense suppression therapy moderates MPS I-H disease progression.Q37619694
The A-Z of bacterial translation inhibitorsQ37636017
Call of the wild: antibiotic resistance genes in natural environmentsQ37700168
Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and actionQ37970718
Elements of ribosomal drug resistance and specificity.Q38043799
Ribosome-targeting antibiotics and mechanisms of bacterial resistance.Q38171225
Probing the initiation complex formation on E coli ribosomes using short complementary DNA oligomersQ38334574
Effects of antisense DNA against the alpha-sarcin stem-loop structure of the ribosomal 23S rRNA.Q38352201
Structure and Function of the Mitochondrial RibosomeQ38792620
Electrochemically monitoring the antibiotic susceptibility of Pseudomonas aeruginosa biofilms.Q38961144
Specific, efficient, and selective inhibition of prokaryotic translation initiation by a novel peptide antibioticQ34248263
Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolatesQ34315537
Sequence selectivity of macrolide-induced translational attenuationQ34442039
Increased selectivity toward cytoplasmic versus mitochondrial ribosome confers improved efficiency of synthetic aminoglycosides in fixing damaged genes: a strategy for treatment of genetic diseases caused by nonsense mutationsQ34475657
Structure-based drug design meets the ribosomeQ34489129
Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureusQ34497915
The general mode of translation inhibition by macrolide antibioticsQ34526342
Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA bindingQ34543629
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosomeQ34580969
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencingQ34630593
Mechanisms of antibiotic resistance in Staphylococcus aureusQ34657311
High-resolution structures of large ribosomal subunits from mesophilic eubacteria and halophilic archaea at various functional StatesQ34948150
Environmental pollution by antibiotics and by antibiotic resistance determinantsQ34989442
Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistanceQ35005203
Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPasesQ35007821
A novel site of antibiotic action in the ribosome: interaction of evernimicin with the large ribosomal subunit.Q35037268
Role of antibiotic ligand in nascent peptide-dependent ribosome stallingQ35081639
Antibiotics acting on the translational machineryQ35086152
Bactobolin A binds to a site on the 70S ribosome distinct from previously seen antibioticsQ35095601
Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNAQ35101167
Low fitness cost of the multidrug resistance gene cfr.Q35139469
Cryo-EM structure of the tetracycline resistance protein TetM in complex with a translating ribosome at 3.9-Å resolutionQ35567060
High-resolution structure of the Escherichia coli ribosome.Q35598643
Oxacillin sensitization of methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus pseudintermedius by antisense peptide nucleic acids in vitroQ35839071
Term-seq reveals abundant ribo-regulation of antibiotics resistance in bacteriaQ36000911
A platform for the discovery of new macrolide antibiotics.Q36021739
Species-specific antibiotic-ribosome interactions: implications for drug developmentQ36334935
Multidrug-resistance efflux pumps - not just for resistanceQ36538111
Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitorsQ36593851
Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.Q36701091
Erythromycin Resistance Peptides Selected from Random Peptide LibrariesQ36869393
Structural basis for cross-resistance to ribosomal PTC antibioticsQ37020720
Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosomeQ37086516
Advances in MRSA drug discovery: where are we and where do we need to be?Q37112508
Programmed drug-dependent ribosome stallingQ37378026
P921main subjectantibioticQ12187
P1104number of pages17
P304page(s)567-583
P577publication date2017-06-01
P1433published inAnnual Review of BiochemistryQ567356
P1476titleA Bright Future for Antibiotics?
P478volume86

Reverse relations

cites work (P2860)
Q93170718A screening platform to monitor RNA processing and protein-RNA interactions in ribonuclease P uncovers a small molecule inhibitor
Q91304272Discovery of Small-Molecule Antibiotics against a Unique tRNA-Mediated Regulation of Transcription in Gram-Positive Bacteria
Q48178037Life under the Microscope: Single-Molecule Fluorescence Highlights the RNA World
Q61984910RETRACTED: Translation Elongation Factor 4 (LepA) Contributes to Tetracycline Susceptibility by Stalling Elongating Ribosomes
Q49605103Regulatory Roles of Mitochondrial Ribosome in Lung Diseases and Single Cell Biology
Q92527744Structures of lipoprotein signal peptidase II from Staphylococcus aureus complexed with antibiotics globomycin and myxovirescin

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