Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression.

scientific article published on 12 August 2011

Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.229633
P932PMC publication ID3190817
P698PubMed publication ID21841002

P50authorNicola BucknerQ84762060
Peter DaviesQ42689763
P2093author name stringSu Wu
Michael L Hutton
Michael J O'Neill
Martin Citron
Claire V Cella
Tracey K Murray
Xiyun Chai
Helen Sims
Jenna Hanmer
Robert Kinley
P2860cites workAlzheimer-related tau-pathology in the perforant path target zone and in the hippocampal stratum oriens and radiatum correlates with onset and degree of dementiaQ73721145
Transmission and spreading of tauopathy in transgenic mouse brainQ24651334
Active and passive immunotherapy for neurodegenerative disordersQ24657879
Tau protein, the paired helical filament and Alzheimer's diseaseQ28258279
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17Q28274687
Tau suppression in a neurodegenerative mouse model improves memory functionQ29615831
A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresisQ33720044
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic miceQ34687145
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse modelQ35104249
Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplificationQ35946218
Laboratory Investigation of Cerebrospinal Fluid ProteinsQ36623870
Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubilityQ39420678
Tau phosphorylated at tyrosine 394 is found in Alzheimer's disease tangles and can be a product of the Abl-related kinase, Arg.Q39746633
Propagation of tau misfolding from the outside to the inside of a cell.Q39873721
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.Q40090247
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseQ41753192
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau proteinQ42491661
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.Q44205872
Intracranially Administered Anti-Αβ Antibodies Reduce β-Amyloid Deposition by Mechanisms Both Independent of and Associated with Microglial ActivationQ44433388
cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease.Q48128979
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in miceQ48166478
Accumulation of pathological tau species and memory loss in a conditional model of tauopathy.Q48217044
Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies.Q48392869
Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau proteinQ48400266
Monoclonal antibody PHF-1 recognizes tau protein phosphorylated at serine residues 396 and 404.Q53199978
Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.Q54613756
P433issue39
P407language of work or nameEnglishQ1860
P921main subjectantibodyQ79460
immunizationQ1415366
passive immunizationQ73525231
P304page(s)34457-34467
P577publication date2011-08-12
P1433published inJournal of Biological ChemistryQ867727
P1476titlePassive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression
P478volume286