Current State of Stem Cell Therapy for Ischemic Heart Disease

scientific article published in January 2016

Current State of Stem Cell Therapy for Ischemic Heart Disease is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1014811607
P356DOI10.1007/S11886-015-0693-6
P698PubMed publication ID26768743

P2093author name stringThomas J Povsic
P2860cites workEffects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studiesQ81851071
Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signalingQ83323467
A double-blind, randomized, controlled, multicenter study to assess the safety and cardiovascular effects of skeletal myoblast implantation by catheter delivery in patients with chronic heart failure after myocardial infarctionQ85063680
A phase 3, randomized, double-blinded, active-controlled, unblinded standard of care study assessing the efficacy and safety of intramyocardial autologous CD34+ cell administration in patients with refractory angina: design of the RENEW studyQ86853989
Autologous transplantation of mononuclear bone marrow cells in patients with acute myocardial infarction: the effect of the dose of transplanted cells on myocardial function.Q50774320
Intramyocardial transplantation of autologous CD34+ stem cells for intractable angina: a phase I/IIa double-blind, randomized controlled trial.Q50981942
CD34(+) cell infusion after ST elevation myocardial infarction is associated with improved perfusion and is dose dependent.Q53254720
Prospective randomized trial of direct endomyocardial implantation of bone marrow cells for treatment of severe coronary artery diseases (PROTECT-CAD trial).Q53455003
Circulating progenitor cells can be reliably identified on the basis of aldehyde dehydrogenase activity.Q53512458
Comparative effects of mesenchymal progenitor cells, endothelial progenitor cells, or their combination on myocardial infarct regeneration and cardiac function.Q53518783
Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trialQ56610959
Cardiopoietic Stem Cell Therapy in Heart FailureQ57779306
Functional impairment of hematopoietic progenitor cells in patients with coronary heart diseaseQ58863641
Reparative Effects of Allogeneic Mesenchymal Precursor Cells Delivered Transendocardially in Experimental Nonischemic CardiomyopathyQ58865316
Intracoronary infusion of mononuclear cells from bone marrow or peripheral blood compared with standard therapy in patients after acute myocardial infarction treated by primary percutaneous coronary intervention: results of the randomized controlledQ59260969
Mesenchymal Stem Cells Provide Better Results Than Hematopoietic Precursors for the Treatment of Myocardial InfarctionQ59938198
Short- and long-term outcomes of intracoronary and endogenously mobilized bone marrow stem cells in the treatment of ST-segment elevation myocardial infarction: a meta-analysis of randomized control trialsQ61649093
Regenerating functional myocardium: Improved performance after skeletal myoblast transplantationQ61776512
Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre Myocardial Regeneration by IntQ61942700
Number and Function of Endothelial Progenitor Cells as a Marker of Severity for Diabetic VasculopathyQ63285824
Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemiaQ73395331
Chimerism of the transplanted heartQ77452324
Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human heartsQ77885470
Autologous bone-marrow stem-cell transplantation for myocardial regenerationQ78761519
Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarctionQ79289222
CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cellsQ79317344
Intramyocardial delivery of CD133+ bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studiesQ79826696
Sustained effect of autologous bone marrow mononuclear cell injection in patients with refractory angina pectoris and chronic myocardial ischemia: twelve-month follow-up resultsQ80333368
Intracoronary Bone Marrow–Derived Progenitor Cells in Acute Myocardial InfarctionQ22250889
Evidence for cardiomyocyte renewal in humansQ24594522
The multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodesQ28199117
Isolation of putative progenitor endothelial cells for angiogenesisQ28302884
Heart regeneration in zebrafishQ29619776
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trialQ29620043
Paracrine mechanisms in adult stem cell signaling and therapyQ29620571
Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials.Q30444845
Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarctionQ30496413
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarctionQ30824170
Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trialQ31033745
Infarct remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insights from serial contrast-enhanced magnetic resonance imagingQ33193903
Intracoronary infusion of autologous bone marrow cells and left ventricular function after acute myocardial infarction: a meta-analysisQ33258314
Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarctionQ33273736
Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysisQ33285990
Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic reviewQ33340205
Effects of intracoronary injection of mononuclear bone marrow cells on left ventricular function, arrhythmia risk profile, and restenosis after thrombolytic therapy of acute myocardial infarction.Q33374961
Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trialQ33950809
The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) trial: first randomized placebo-controlled study of myoblast transplantation.Q34010010
Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trialQ34074673
Patients with coronary artery disease not amenable to traditional revascularization: prevalence and 3-year mortality.Q34113038
Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trialQ34332467
Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a meta-analysis of randomised controlled clinical trialsQ34372154
Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trialQ34467911
Intramyocardial injection of bone marrow mononuclear cells in chronic myocardial ischemia patients after previous placebo injection improves myocardial perfusion and anginal symptoms: an intra-patient comparisonQ34471244
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trialQ34544699
Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe anginaQ34547211
Antianginal efficacy of ranolazine when added to treatment with amlodipine: the ERICA (Efficacy of Ranolazine in Chronic Angina) trialQ34569443
Meta-analysis of stem cell therapy in chronic ischemic cardiomyopathy.Q34691429
Bone Marrow Stem Cell Treatment for Ischemic Heart Disease in Patients with No Option of Revascularization: A Systematic Review and Meta-AnalysisQ34804229
Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularizationQ35111623
Predictors of long-term clinical endpoints in patients with refractory anginaQ35135665
Intramyocardial, autologous CD34+ cell therapy for refractory anginaQ35308043
Meta-analysis of cell therapy trials for patients with heart failureQ35551127
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cellsQ35799278
Surgical treatment for congestive heart failure with autologous adult stem cell transplantation: a prospective randomized studyQ36322384
Effect of transendocardial delivery of autologous bone marrow mononuclear cells on functional capacity, left ventricular function, and perfusion in chronic heart failure: the FOCUS-CCTRN trialQ36694346
Mesenchymal stem cells for vascular regenerationQ37000697
Aging and disease as modifiers of efficacy of cell therapyQ37183949
Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial designQ37340293
Depletion of circulating progenitor cells precedes overt diabetes: a substudy from the VA enhanced fitness trialQ37418276
Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarctionQ37444118
Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysisQ38021450
Treatment of refractory angina in patients not suitable for revascularizationQ38173640
Intramyocardial bone marrow cell injection for chronic myocardial ischemia: a randomized controlled trialQ38381605
PreSERVE-AMI: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Intracoronary Administration of Autologous CD34+ Cells in Patients With Left Ventricular Dysfunction Post STEMI.Q38384991
Repeated Intramyocardial Bone Marrow Cell Injection in Previously Responding Patients With Refractory Angina Again Improves Myocardial Perfusion, Anginal Complaints, and Quality of LifeQ38406348
Intracoronary stem cell infusion after acute myocardial infarction: a meta-analysis and update on clinical trialsQ39222871
Long-term survival in patients with refractory anginaQ39227491
Final results of a phase IIa, randomised, open-label trial to evaluate the percutaneous intramyocardial transplantation of autologous skeletal myoblasts in congestive heart failure patients: the SEISMIC trialQ39272735
Circulating endothelial progenitor cells, vascular function, and cardiovascular riskQ39513285
Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomised clQ40525372
Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemiaQ40608302
Mobilization of bone marrow-derived Oct-4+ SSEA-4+ very small embryonic-like stem cells in patients with acute myocardial infarctionQ41189527
A Phase II Dose-Escalation Study of Allogeneic Mesenchymal Precursor Cells in Patients With Ischemic or Nonischemic Heart FailureQ41608655
Common endothelial progenitor cell assays identify discrete endothelial progenitor cell populationsQ41907027
Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery diseaseQ42485863
Mobilization of endothelial progenitor cells in patients with acute myocardial infarctionQ43636896
One-year follow-up of feasibility and safety of the first U.S., randomized, controlled study using 3-dimensional guided catheter-based delivery of autologous skeletal myoblasts for ischemic cardiomyopathy (CAuSMIC study).Q44237365
Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failureQ44270472
Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunctionQ44392643
Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failureQ44411377
Stem cell therapy is a promising tool for refractory angina: a meta-analysis of randomized controlled trialsQ44493479
Catheter-based intramyocardial injection of autologous skeletal myoblasts as a primary treatment of ischemic heart failure: clinical experience with six-month follow-upQ44697038
Autologous peripheral stem cell transplantation in patients with congestive heart failure due to ischemic heart diseaseQ44799055
Autologous skeletal myoblast transplantation for the treatment of postinfarction myocardial injury: phase I clinical study with 12 months of follow-up.Q45075945
Intracoronary injection of CD133-positive enriched bone marrow progenitor cells promotes cardiac recovery after recent myocardial infarction: feasibility and safetyQ46700940
Repeat Cell Therapy for Refractory Angina: Déjà vu All Over Again?Q47991504
Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial (MSC-HF trial).Q48039597
Efficacy of a device to narrow the coronary sinus in refractory anginaQ48050685
Long term effects of intramyocardial bone marrow cell injection on anginal symptoms and quality of life in patients with chronic myocardial ischemiaQ48253059
Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens.Q48414650
Direct intramyocardial mesenchymal stromal cell injections in patients with severe refractory angina: one-year follow-upQ48459462
Effect of intracoronary injection of mononuclear bone marrow stem cells on left ventricular function in patients with acute myocardial infarctionQ48831721
P433issue2
P304page(s)17
P577publication date2016-01-01
P1433published inCurrent cardiology reportsQ26842345
P1476titleCurrent State of Stem Cell Therapy for Ischemic Heart Disease
P478volume18

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cites work (P2860)
Q38688641A Novel Role for CAMKK1 in the Regulation of the Mesenchymal Stem Cell Secretome.
Q64104219Effect of stem cell transplantation on patients with ischemic heart failure: a systematic review and meta-analysis of randomized controlled trials
Q55649548Midterm outcomes of transmyocardial laser revascularization with intramyocardial injection of adipose derived stromal cells for severe refractory angina.
Q52685704Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy?
Q57730655Strategies for non-invasive imaging of polymeric biomaterial in vascular tissue engineering and regenerative medicine using ultrasound and photoacoustic techniques

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