Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS.

scientific article

Targeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCITRANSLMED.AAL5253
P698PubMed publication ID28615361

P50authorRebecca EllstonQ38804485
Anna D StaniszewskaQ52430540
Alexey S RevenkoQ91736030
Sarah J RossQ95966782
Sanjay K PandeyQ95966784
Linda K BuckettQ95966785
Stephanie K KleinQ95966786
Paul D LyneQ95966787
Robert MacleodQ95966790
P2093author name stringMichael Zinda
Kevin Hudson
Brett P Monia
Claire Rooney
David C Blakey
Mitchell Revill
Nicky Whalley
Lyndsey L Hanson
P433issue394
P407language of work or nameEnglishQ1860
P577publication date2017-06-01
P1433published inScience Translational MedicineQ1573955
P1476titleTargeting KRAS-dependent tumors with AZD4785, a high-affinity therapeutic antisense oligonucleotide inhibitor of KRAS.
P478volume9

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cites work (P2860)
Q59791008Aberrant RNA Splicing in Cancer and Drug Resistance
Q64970925Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells.
Q48010762Cancer: RNA-based approaches target KRAS.
Q64099030Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor
Q93015891Development and Clinical Trials of Nucleic Acid Medicines for Pancreatic Cancer Treatment
Q64100452Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines
Q57462015Epigenetic Reprogramming with Antisense Oligonucleotides Enhances the Effectiveness of Androgen Receptor Inhibition in Castration-Resistant Prostate Cancer
Q64982130Genetic characterisation of molecular targets in carcinoma of unknown primary.
Q94533157Grifolin, neogrifolin and confluentin from the terricolous polypore Albatrellus flettii suppress KRAS expression in human colon cancer cells
Q48531718Impact of a five-dimensional framework on R&D productivity at AstraZeneca
Q98224914Innovative Therapeutic and Delivery Approaches Using Nanotechnology to Correct Splicing Defects Underlying Disease
Q55263196KRAS mutant allele-specific expression knockdown in pancreatic cancer model with systemically delivered bi-shRNA KRAS lipoplex.
Q92733424KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe
Q92128564MEK nuclear localization promotes YAP stability via sequestering β-TrCP in KRAS mutant cancer cells
Q90706520New Horizons in KRAS-Mutant Lung Cancer: Dawn After Darkness
Q96302844RAS-targeted therapies: is the undruggable drugged?
Q56888903RNAi-Mediated β-Catenin Inhibition Promotes T Cell Infiltration and Antitumor Activity in Combination with Immune Checkpoint Blockade
Q90471584Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer
Q48246978Recent advances in the biology and therapy of medullary thyroid carcinoma.
Q90429889Role of Alternative Splicing in Prostate Cancer Aggressiveness and Drug Resistance in African Americans
Q90702089Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease
Q54962055Targeting KRAS in metastatic colorectal cancer: current strategies and emerging opportunities.
Q93105571Targeting castration-resistant prostate cancer with androgen receptor antisense oligonucleotide therapy
Q49519966Therapeutic Applications of Targeted Alternative Splicing to Cancer Treatment
Q52677752Therapeutic oligonucleotides in cardiovascular and metabolic diseases: insights for the internist.
Q94564366Transcription and Translation Inhibitors in Cancer Treatment

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