KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway

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KIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1085928828
P356DOI10.1038/BJC.2017.165
P8608Fatcat IDrelease_qllxvj5mo5hxvl437czcim4pie
P932PMC publication ID5520515
P698PubMed publication ID28595260

P2093author name stringJie Wang
Jianxin Jiang
Xingjun Guo
Chencheng Xie
P2860cites workKIF5B/RET fusion gene in surgically-treated adenocarcinoma of the lung.Q50927897
Proteomic analysis to identify plasma orosomucoid 2 and kinesin 18A as potential biomarkers of cholangiocarcinoma.Q51754748
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Progress in Discovery of KIF5B-RET Kinase Inhibitors for the Treatment of Non-Small-Cell Lung Cancer.Q55068423
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Kinesin-12, a mitotic microtubule-associated motor protein, impacts axonal growth, navigation, and branching.Q24632164
The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.Q27324657
The crystal structure and biochemical characterization of Kif15: a bifunctional molecular motor involved in bipolar spindle formation and neuronal developmentQ27681300
Comprehensive structural model of the mechanochemical cycle of a mitotic motor highlights molecular adaptations in the kinesin family.Q27681421
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Kinesin-12 Kif15 targets kinetochore fibers through an intrinsic two-step mechanismQ30595517
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KIF2A silencing inhibits the proliferation and migration of breast cancer cells and correlates with unfavorable prognosis in breast cancerQ33825733
Growth arrest signaling of the Raf/MEK/ERK pathway in cancerQ33836237
Kinesin family deregulation coordinated by bromodomain protein ANCCA and histone methyltransferase MLL for breast cancer cell growth, survival, and tamoxifen resistanceQ34069945
Modulated microtubule dynamics enable Hklp2/Kif15 to assemble bipolar spindlesQ34227164
Expression of the mitotic kinesin Kif15 in postmitotic neurons: Implications for neuronal migration and developmentQ34276933
ERK implication in cell cycle regulationQ34594561
Kif15 cooperates with eg5 to promote bipolar spindle assemblyQ35007385
Kinesin family member 4A: a potential predictor for progression of human oral cancerQ35081235
Evaluation of KIF23 variant 1 expression and relevance as a novel prognostic factor in patients with hepatocellular carcinomaQ35870679
Cancer-related CD15/FUT4 overexpression decreases benefit to agents targeting EGFR or VEGF acting as a novel RAF-MEK-ERK kinase downstream regulator in metastatic colorectal cancer.Q36110794
Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancerQ36454371
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Pancreatic Adenocarcinoma, version 2.2012: featured updates to the NCCN Guidelines.Q37252144
KIF23 is an independent prognostic biomarker in glioma, transcriptionally regulated by TCF-4.Q37269393
Role and regulation of kinesin-8 motors through the cell cycleQ38241195
Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancerQ38294104
Overexpression of integrin αv facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin αvβ8 with type Ⅰ collagenQ38304434
The Kinesin-12 Kif15 is a processive track-switching tetramerQ38497128
PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: Structural and pharmacological perspectivesQ38710627
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma.Q38769261
Overexpression of KIF23 predicts clinical outcome in primary lung cancer patientsQ38802739
KIF1B promotes glioma migration and invasion via cell surface localization of MT1-MMP.Q38818997
Kinesin 18A expression: clinical relevance to colorectal cancer progression.Q39611073
Molecular pathways: adaptive kinome reprogramming in response to targeted inhibition of the BRAF-MEK-ERK pathway in cancerQ39697330
Curcumin inhibits constitutive STAT3 phosphorylation in human pancreatic cancer cell lines and downregulation of survivin/BIRC5 gene expressionQ39745459
Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytesQ39918833
A unique gene having homology with the kinesin family member 18A encodes a tumour-associated antigen recognised by cytotoxic T lymphocytes from HLA-A2+ colon cancer patientsQ40413050
Myc induces cyclin D1 expression in the absence of de novo protein synthesis and links mitogen-stimulated signal transduction to the cell cycle.Q41426806
C-Kit Promotes Growth and Migration of Human Cardiac Progenitor Cells via the PI3K-AKT and MEK-ERK PathwaysQ41813361
Reconstruction of an integrated genome-scale co-expression network reveals key modules involved in lung adenocarcinomaQ43095950
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 InternationalQ42553662
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
P304page(s)245-255
P577publication date2017-06-08
P1433published inBritish Journal of CancerQ326309
P1476titleKIF15 promotes pancreatic cancer proliferation via the MEK-ERK signalling pathway
P478volume117

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cites work (P2860)
Q100431708B7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer
Q89613632Development of a 15-gene signature for predicting prognosis in advanced colorectal cancer
Q61453962Distinct Diagnostic and Prognostic Values of Kinesin Family Member Genes Expression in Patients with Breast Cancer
Q65000057ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer.
Q90426057Effect of KIF22 on promoting proliferation and migration of gastric cancer cells via MAPK-ERK pathways
Q91928964Exploring the Molecular Mechanism of the Drug-Treated Breast Cancer Based on Gene Expression Microarray
Q97073426GINS2 affects cell viability, cell apoptosis, and cell cycle progression of pancreatic cancer cells via MAPK/ERK pathway
Q93173697Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma
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Q93047521Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway
Q97543664KIF11 and KIF15 mitotic kinesins are potential therapeutic vulnerabilities for malignant peripheral nerve sheath tumors
Q89929998KIF15 Expression in Tumor-associated Monocytes Is a Prognostic Biomarker in Hepatocellular Carcinoma
Q92134426KIF15 Promotes Proliferation and Growth of Hepatocellular Carcinoma
Q93164713KIF15 facilitates gastric cancer via enhancing proliferation, inhibiting apoptosis, and predict poor prognosis
Q64099522KIF15 promotes bladder cancer proliferation via the MEK-ERK signaling pathway
Q55073830KIF4A facilitates cell proliferation via induction of p21-mediated cell cycle progression and promotes metastasis in colorectal cancer.
Q92241114KIF5A Promotes Bladder Cancer Proliferation In Vitro and In Vivo
Q64113663LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway
Q60916561Mutations Defining Patient Cohorts With Elevated PD-L1 Expression in Gastric Cancer
Q58796673SPARCL1 suppresses the proliferation and migration of human ovarian cancer cells via the MEK/ERK signaling
Q64910335m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways.

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