Genetic load makes cancer cells more sensitive to common drugs: evidence from Cancer Cell Line Encyclopedia

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Genetic load makes cancer cells more sensitive to common drugs: evidence from Cancer Cell Line Encyclopedia is …
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scholarly articleQ13442814

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P818arXiv ID1705.05921
P6179Dimensions Publication ID1085379452
P356DOI10.1038/S41598-017-02178-1
P932PMC publication ID5434051
P698PubMed publication ID28512298

P2093author name stringKirill S Korolev
Ana B Pavel
P2860cites workFitness and its role in evolutionary geneticsQ22122004
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Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
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Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinibQ28263625
R Regulation of tumor angiogenesis and metastasis by FGF and PDGF signaling pathwaysQ28275289
DNA topoisomerases and their poisoning by anticancer and antibacterial drugsQ28284744
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Somatic mutation, genomic variation, and neurological diseaseQ28395313
Assessment of pharmacogenomic agreementQ28597117
Antibody neutralization and escape by HIV-1Q29547345
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
Circular binary segmentation for the analysis of array-based DNA copy number dataQ29615406
MAP kinase signalling pathways in cancerQ29615542
Cell cycle checkpoint signaling through the ATM and ATR kinasesQ29617837
Genetic basis for clinical response to CTLA-4 blockade in melanomaQ29620594
Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesisQ30311954
GSVA: gene set variation analysis for microarray and RNA-seq data.Q30586230
Integrating mutation and gene expression cross-sectional data to infer cancer progressionQ31039903
Integrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activityQ31044138
Integrating heterogeneous drug sensitivity data from cancer pharmacogenomic studies.Q31109155
Identifying cancer type specific oncogenes and tumor suppressors using limited size dataQ31135256
Human cancers express mutator phenotypes: origin, consequences and targetingQ33554201
Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell linesQ33742964
The temporal order of genetic and pathway alterations in tumorigenesisQ34070603
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Tobacco, colorectal cancer, and adenomas: a review of the evidenceQ34409468
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G-protein-coupled receptors and cancer.Q34606002
Evolutionary triage governs fitness in driver and passenger mutations and suggests targeting never mutations.Q34662452
Paradoxical relationship between chromosomal instability and survival outcome in cancerQ34988001
BRCA1 regulation of epidermal growth factor receptor (EGFR) expression in human breast cancer cells involves microRNA-146a and is critical for its tumor suppressor functionQ36539643
Impact of deleterious passenger mutations on cancer progressionQ36637272
The IGF-I signaling pathwayQ36754655
Signal integration by JNK and p38 MAPK pathways in cancer developmentQ37560607
High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanomaQ38926293
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The mutational meltdown in asexual populationsQ41067565
Fitness of RNA virus decreased by Muller's ratchetQ41211936
The effect of deleterious alleles on adaptation in asexual populations.Q42534673
Turning ecology and evolution against cancerQ46904792
Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability.Q52012209
The accumulation of deleterious genes in a population--Muller's RatchetQ67444775
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesGSVAQ113334751
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcell lineQ21014462
cancer cell lineQ23058136
P304page(s)1938
P577publication date2017-05-16
P1433published inScientific ReportsQ2261792
P1476titleGenetic load makes cancer cells more sensitive to common drugs: evidence from Cancer Cell Line Encyclopedia
P478volume7

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