Adverse events associated with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia

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Adverse events associated with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia is …
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scholarly articleQ13442814

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P356DOI10.1517/14740338.2016.1145654
P698PubMed publication ID26799331

P50authorGiuliana AlimenaQ66370852
Massimo BrecciaQ66370920
P2093author name stringGioia Colafigli
Matteo Molica
P2860cites workSystematic review of dasatinib in chronic myeloid leukemiaQ24596026
Ponatinib in refractory Philadelphia chromosome-positive leukemiasQ27851967
Multicenter Independent Assessment of Outcomes in Chronic Myeloid Leukemia Patients Treated With ImatinibQ29999611
Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV.Q30891587
15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytesQ33380951
Dasatinib or imatinib in newly diagnosed chronic-phase chronic myeloid leukemia: 2-year follow-up from a randomized phase 3 trial (DASISION).Q33398716
A phase 2 trial of ponatinib in Philadelphia chromosome-positive leukemiasQ33411250
Bosutinib efficacy and safety in chronic phase chronic myeloid leukemia after imatinib resistance or intolerance: Minimum 24-month follow-upQ33414487
Severe thrombocytopenia after dasatinib treatment in a patient with Philadelphia chromosome-positive chronic myeloid leukemia.Q33422727
Chronic myelogenous leukemia: biology and therapyQ33700942
Early onset hypercholesterolemia induced by the 2nd-generation tyrosine kinase inhibitor nilotinib in patients with chronic phase-chronic myeloid leukemiaQ33828570
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.Q33997854
Chronic Myeloid Leukemia — Advances in Biology and New Approaches to TreatmentQ34268535
Congestive heart failure is a rare event in patients receiving imatinib therapyQ34621382
Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study.Q34639998
Safety of bosutinib versus imatinib in the phase 3 BELA trial in newly diagnosed chronic phase chronic myeloid leukemiaQ35008618
Molecular mechanisms of transformation by the BCR-ABL oncogeneQ35143823
Charlson comorbidity index and adult comorbidity evaluation-27 scores might predict treatment compliance and development of pleural effusions in elderly patients with chronic myeloid leukemia treated with second-line dasatinibQ35265868
Regulation of the c-Abl and Bcr-Abl tyrosine kinasesQ35621355
Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the International Randomized Study of Interferon and STI571 (IRIS)Q35694453
Biology of chronic myelogenous leukemia--signaling pathways of initiation and transformationQ35844144
The development of imatinib as a therapeutic agent for chronic myeloid leukemiaQ35993288
Long-term outcome of a phase 2 trial with nilotinib 400 mg twice daily in first-line treatment of chronic myeloid leukemiaQ36708942
Long-term efficacy and safety of bosutinib in patients with advanced leukemia following resistance/intolerance to imatinib and other tyrosine kinase inhibitorsQ37461942
Class effects of tyrosine kinase inhibitors in the treatment of chronic myeloid leukemiaQ37498272
Cardiotoxicity induced by tyrosine kinase inhibitorsQ37593059
Current therapeutics and practical management strategies for pulmonary arterial hypertensionQ37915711
Therapeutic targeting of BCR-ABL: prognostic markers of response and resistance mechanism in chronic myeloid leukaemiaQ37999439
Occurrence and current management of side effects in chronic myeloid leukemia patients treated frontline with tyrosine kinase inhibitorsQ38087737
Second-Generation Tyrosine Kinase Inhibitors (Tki) as Salvage Therapy for Resistant or Intolerant Patients to Prior TKIsQ38181111
Systemic therapy options for advanced gastrointestinal stromal tumors beyond first-line imatinib: a systematic review.Q38527941
Clinical features of pulmonary arterial hypertension in patients receiving dasatinibQ38568955
Bosutinib for Chronic Myeloid LeukemiaQ38835127
Dasatinib inhibits proinflammatory functions of mature human neutrophilsQ41885572
The incidence of pleural and pericardial effusion is not higher in patients receiving dasatinib at low doses. (Reply).Q42708667
Mechanism of impaired glucose metabolism during nilotinib therapy in patients with chronic myelogenous leukemiaQ42958726
Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studiesQ43178207
Nilotinib for the frontline treatment of Ph(+) chronic myeloid leukemiaQ43262982
Health-related quality of life in chronic myeloid leukemia patients receiving long-term therapy with imatinib compared with the general populationQ44306071
Quality of life in patients with newly diagnosed chronic phase chronic myeloid leukemia on imatinib versus interferon alfa plus low-dose cytarabine: results from the IRIS StudyQ44459252
Long-term response to imatinib is not affected by the initial dose in patients with Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase: final update from the Tyrosine Kinase Inhibitor Optimization and Selectivity (TOPS) stQ45024357
Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapyQ46084072
Six-year follow-up of patients receiving imatinib for the first-line treatment of chronic myeloid leukemiaQ46090252
Pulmonary arterial hypertension in patients treated by dasatinibQ46176185
Reversible dasatinib-induced pulmonary arterial hypertension and right ventricle failure in a previously allografted CML patientQ46185511
Reversible severe pulmonary hypertension secondary to dasatinib in a patient with chronic myeloid leukemiaQ46262660
An evaluation of the cardiotoxicity of imatinib mesylateQ46583056
Cardiac events in imatinib mesylate-treated chronic myeloid leukemia patients: A single institution experienceQ46974546
Impact of low-grade adverse events on health-related quality of life in adult patients receiving imatinib or nilotinib for newly diagnosed Philadelphia chromosome positive chronic myelogenous leukemia in chronic phaseQ48070812
Usefulness of the 2012 European CVD risk assessment model to identify patients at high risk of cardiovascular events during nilotinib therapy in chronic myeloid leukemia.Q50998286
Application of systematic coronary risk evaluation chart to identify chronic myeloid leukemia patients at risk of cardiovascular diseases during nilotinib treatment.Q51107664
Progressive peripheral arterial occlusive disease and other vascular events during nilotinib therapy in CML.Q51373837
Peripheral artery occlusive disease in chronic phase chronic myeloid leukemia patients treated with nilotinib or imatinib.Q52884682
Deep molecular response is reached by the majority of patients treated with imatinib, predicts survival, and is achieved more quickly by optimized high-dose imatinib: results from the randomized CML-study IV.Q53098953
Severe peripheral arterial disease during nilotinib therapy.Q54419090
Rates of peripheral arterial occlusive disease in patients with chronic myeloid leukemia in the chronic phase treated with imatinib, nilotinib, or non-tyrosine kinase therapy: a retrospective cohort analysis.Q54446241
Managing side effects of tyrosine kinase inhibitor therapy to optimize adherence in patients with chronic myeloid leukemia: the role of the midlevel practitioner.Q54536381
Nilotinib therapy does not induce consistent modifications of cholesterol metabolism resulting in clinical consequences.Q54567948
Pleural Effusion in Patients With Chronic Myelogenous Leukemia Treated With Dasatinib After Imatinib FailureQ57731587
Potent, transient inhibition of BCR-ABL with dasatinib 100 mg daily achieves rapid and durable cytogenetic responses and high transformation-free survival rates in chronic phase chronic myeloid leukemia patients with resistance, suboptimal response oQ58023854
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectchronic myeloid leukemiaQ729735
leukemiaQ29496
P304page(s)525-533
P577publication date2016-01-22
P1433published inExpert Opinion on Drug SafetyQ5421206
P1476titleAdverse events associated with tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia
P478volume15

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cites work (P2860)
Q47139100Bardoxolone methyl (CDDO-Me or RTA402) induces cell cycle arrest, apoptosis and autophagy via PI3K/Akt/mTOR and p38 MAPK/Erk1/2 signaling pathways in K562 cells
Q42367946Development of a protease-resistant reporter to quantify BCR-ABL activity in intact cells
Q42011392Genetic predisposition and induced pro-inflammatory/pro-oxidative status may play a role in increased atherothrombotic events in nilotinib treated chronic myeloid leukemia patients.
Q38789049Second line small molecule therapy options for treating chronic myeloid leukemia

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