HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients.

scientific article published on June 2017

HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.CELREP.2017.05.078
P932PMC publication ID5489699
P698PubMed publication ID28636940

P50authorChrisostomos ProdromouQ28317140
P2093author name stringLaurence H Pearl
Zhaobo Li
Velibor Savic
Lihong Zhou
P2860cites workQuantitative analysis of HSP90-client interactions reveals principles of substrate recognitionQ24297748
The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of TaraQ24306505
CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complexQ24336508
p50(cdc37) acting in concert with Hsp90 is required for Raf-1 functionQ24554532
The ATPase cycle of Hsp90 drives a molecular 'clamp' via transient dimerization of the N-terminal domainsQ24599484
Building and remodelling Cullin-RING E3 ubiquitin ligasesQ27027816
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analoguesQ27644429
Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperoneQ27740876
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycinQ27766755
ErbB2 degradation mediated by the co-chaperone protein CHIPQ28208008
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasisQ28276567
Interaction between syntaxin 8 and HECTd3, a HECT domain ligaseQ28587299
Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinasesQ28609156
HSP90 at the hub of protein homeostasis: emerging mechanistic insightsQ29616824
Physiological functions of the HECT family of ubiquitin ligasesQ29617293
Crystal structure of an Hsp90-nucleotide-p23/Sba1 closed chaperone complexQ29617515
Animal HECT ubiquitin ligases: evolution and functional implicationsQ33533462
E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cellsQ33606911
ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivoQ33889333
Chaperone-dependent E3 ubiquitin ligase CHIP mediates a degradative pathway for c-ErbB2/NeuQ34190181
ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 systemQ34333456
Biogenesis of lysosome-related organelles complex-1 subunit 1 (BLOS1) interacts with sorting nexin 2 and the endosomal sorting complex required for transport-I (ESCRT-I) component TSG101 to mediate the sorting of epidermal growth factor receptor intQ34355752
p185erbB2 binds to GRP94 in vivo. Dissociation of the p185erbB2/GRP94 heterocomplex by benzoquinone ansamycins precedes depletion of p185erbB2.Q34377527
Inhibition of HSP90 by AT13387 delays the emergence of resistance to BRAF inhibitors and overcomes resistance to dual BRAF and MEK inhibition in melanoma modelsQ34677194
Hsp90 molecular chaperone inhibitors: are we there yet?Q35655105
Hsp90 and Cdc37 -- a chaperone cancer conspiracy.Q36015525
Inhibitors of the HSP90 molecular chaperone: current statusQ36543819
The HECTD3 E3 ubiquitin ligase suppresses cisplatin-induced apoptosis via stabilizing MALT1.Q36567564
The HSP90 inhibitor NVP-AUY922 potently inhibits non-small cell lung cancer growthQ36926960
The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8Q37357126
Regulation of Hsp90 client proteins by a Cullin5-RING E3 ubiquitin ligaseQ37453413
Hallmarks of alternative splicing in cancerQ38171229
CHIP: a co-chaperone for degradation by the proteasomeQ38285306
Molecular functions of NEDD4 E3 ubiquitin ligases in cancerQ38538927
Overcoming acquired BRAF inhibitor resistance in melanoma via targeted inhibition of Hsp90 with ganetespibQ39036720
Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycinQ41168181
Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras AssociationQ41282697
Structures of APC/C(Cdh1) with substrates identify Cdh1 and Apc10 as the D-box co-receptorQ41617016
A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cellsQ43577973
Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignanciesQ46551678
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P433issue12
P304page(s)2515-2528
P577publication date2017-06-01
P1433published inCell ReportsQ5058165
P1476titleHECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients
P478volume19

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cites work (P2860)
Q88641892Decanalizing thinking on genetic canalization
Q58763474Expression profiling of ubiquitin-related genes in LKB1 mutant lung adenocarcinoma
Q54111191Herpes Simplex Virus 1 Inhibits TANK-Binding Kinase 1 through Formation of the Us11-Hsp90 Complex.
Q92864486Hsp90B enhances MAST1-mediated cisplatin resistance by protecting MAST1 from proteosomal degradation
Q92135619Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target
Q90482001The functions and properties of cullin-5, a potential therapeutic target for cancers

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