Molecular inflation, attrition and the rule of five

scientific article published on 30 January 2016

Molecular inflation, attrition and the rule of five is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.ADDR.2016.01.018
P698PubMed publication ID26836397

P2093author name stringPaul D Leeson
P2860cites workMolecular complexity and its impact on the probability of finding leads for drug discoveryQ30993107
Is there a difference between leads and drugs? A historical perspectiveQ31017131
Chemical predictive modelling to improve compound qualityQ38167262
Comparing Measures of Promiscuity and Exploring Their Relationship to ToxicityQ51434929
P407language of work or nameEnglishQ1860
P304page(s)22-33
P577publication date2016-01-30
P13046publication type of scholarly workreview articleQ7318358
P1433published inAdvanced Drug Delivery ReviewsQ2825362
P1476titleMolecular inflation, attrition and the rule of five
P478volume101

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cites work (P2860)
Q61813071Application of Permeation Enhancers in Oral Delivery of Macromolecules: An Update
Q47780833Automating drug discovery
Q38835159BDDCS, the Rule of 5 and drugability
Q47895991CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain.
Q90476028Chemical Space Overlap with Critical Protein-Protein Interface Residues in Commercial and Specialized Small-Molecule Libraries
Q55364364Clinical Trials for Disease-Modifying Therapies in Alzheimer's Disease: A Primer, Lessons Learned, and a Blueprint for the Future.
Q38732067Computational analysis of calculated physicochemical and ADMET properties of protein-protein interaction inhibitors
Q26765392Computational prediction of formulation strategies for beyond-rule-of-5 compounds
Q36342657Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine
Q47317732FAF-Drugs4: free ADME-tox filtering computations for chemical biology and early stages drug discovery
Q99589896In Vitro Biopredictive Methods: A Workshop Summary Report
Q92256354Ionic Liquid Forms of the Antimalarial Lumefantrine in Combination with LFCS Type IIIB Lipid-Based Formulations Preferentially Increase Lipid Solubility, In Vitro Solubilization Behavior and In Vivo Exposure
Q51313759Lipophilicity in Drug Development: Too Much or Not Enough?
Q104569806Mechanistic Oral Absorption Modeling of Halofantrine: Exploring the Role of Intestinal Lymphatic Transport
Q39411779Review and analysis of FDA approved drugs using lipid-based formulations.
Q91750784Setting Our Sights on Infectious Diseases
Q51050981Systematic Understanding of the Mechanism of Salvianolic Acid A via Computational Target Fishing
Q64075810Systematic elucidation of the mechanism of geraniol via network pharmacology

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