Population Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia

scientific article published on 17 June 2017

Population Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PSP4.12218
P932PMC publication ID5613184
P698PubMed publication ID28623849

P50authorDaniel GonzalezQ86888058
Michael Cohen-WolkowiezQ93049830
P2093author name stringCharles Peloquin
DAPPER Study Group
David Jacobus
Jeffrey T Guptill
Kathy Aleš
Laura Jacobus
Nilay Thakkar
P2860cites workA web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotypeQ24655489
3,4-diaminopyridine. A potent new potassium channel blockerQ28271710
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Novel drug of choice in Eaton-Lambert syndromeQ33618996
Practical aspects of 3,4-diaminopyridine treatment of the Lambert-Eaton myasthenic syndromeQ34060833
Identifying a cut-off point for normal mobility: a comparison of the timed 'up and go' test in community-dwelling and institutionalised elderly womenQ34193620
Update on treatment options for Lambert-Eaton myasthenic syndrome: focus on use of amifampridineQ34206472
Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies.Q34233555
Pathogenic autoantibodies in the lambert-eaton myasthenic syndromeQ34542963
Prognostic validity of the Timed Up-and-Go test, a modified Get-Up-and-Go test, staff's global judgement and fall history in evaluating fall risk in residential care facilitiesQ34783225
Genetic variation in aryl N-acetyltransferase results in significant differences in the pharmacokinetic and safety profiles of amifampridine (3,4-diaminopyridine) phosphateQ35049590
Population pharmacokinetics of artemether, lumefantrine, and their respective metabolites in Papua New Guinean children with uncomplicated malariaQ35363704
Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypesQ35774965
A bodyweight-dependent allometric exponent for scaling clearance across the human life-span.Q35949142
Diagnosing model diagnosticsQ36850144
Piraña and PCluster: a modeling environment and cluster infrastructure for NONMEM.Q38428553
A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndromeQ39529443
Amifampridine phosphate (Firdapse(®)) is effective and safe in a phase 3 clinical trial in LEMS.Q40350903
3,4-Diaminopyridine is more effective than placebo in a randomized, double-blind, cross-over drug study in LEMS.Q43282674
Minimal detectable change of the timed "up & go" test and the dynamic gait index in people with Parkinson disease.Q44447857
3,4-Diaminopyridine in the treatment of Lambert-Eaton myasthenic syndromeQ44449823
Efficacy of 3,4-diaminopyridine and pyridostigmine in the treatment of Lambert-Eaton myasthenic syndrome: a randomized, double-blind, placebo-controlled, crossover study.Q46055747
Effect of 3,4-diaminopyridine at the murine neuromuscular junctionQ46441845
Population pharmacokinetics of busulfan in children: increased evidence for body surface area and allometric body weight dosing of busulfan in childrenQ47355479
3,4-Diaminopyridine (DAP) in the treatment of Lambert-Eaton myasthenic syndrome (LEMS).Q47826055
Interspecies scaling: predicting volumes, mean residence time and elimination half-life. Some suggestions.Q52240880
The Lambert-Eaton myasthenic syndrome 1988-2008: a clinical picture in 97 patients.Q59394075
Antibodies to motor nerve terminals: an electrophysiological study of a human myasthenic syndrome transferred to mouseQ71147638
Potency of 3,4-Diaminopyridine and 4-aminopyridine on mammalian neuromuscular transmission and the effect of pH changesQ72418552
The Timed Get-up-and-Go test revisited: measurement of the component tasksQ73881064
Electromyography and electric stimulation of nerves in diseases of motor unit; observations on myasthenic syndrome associated with malignant tumorsQ74420444
Xpose--an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEMQ77296898
Age- and gender-related test performance in community-dwelling elderly people: Six-Minute Walk Test, Berg Balance Scale, Timed Up & Go Test, and gait speedsQ77663953
P4510describes a project that usesRStudioQ4798119
ggplot2Q326489
P433issue9
P921main subjectpharmacokineticsQ323936
pharmacodynamicsQ725307
P304page(s)625-634
P577publication date2017-06-17
P1433published inCPT: pharmacometrics & systems pharmacologyQ27724610
P1476titlePopulation Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia
P478volume6

Reverse relations

cites work (P2860)
Q495619973,4-diaminopyridine base effectively treats the weakness of Lambert-Eaton myasthenia
Q57471361Reported direct aminopyridine effects on voltage-gated calcium channels is a high-dose pharmacological off-target effect of no clinical relevance
Q93038062Symptomatic treatment of botulism with a clinically approved small molecule

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