Mutations in NOTCH1 PEST-domain orchestrate CCL19-driven homing of Chronic Lymphocytic Leukemia cells by modulating the tumor suppressor gene DUSP22.

scientific article published on 26 December 2016

Mutations in NOTCH1 PEST-domain orchestrate CCL19-driven homing of Chronic Lymphocytic Leukemia cells by modulating the tumor suppressor gene DUSP22. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1033592844
P356DOI10.1038/LEU.2016.383
P698PubMed publication ID28017968

P50authorRoberto PivaQ37374816
Tiziana VaisittiQ55167915
Francesco NeriQ56812779
Simona CignettoQ57070667
P2093author name stringN Vitale
G Gaidano
J Allan
D Incarnato
D Rossi
B Gizdic
C Bologna
E Mereu
F Arruga
F Diop
G Garaffo
K Gizzi
M Coscia
R Buonincontri
R R Furman
S Deaglio
S Oliviero
S Serra
P2860cites workRegulation of STAT3-mediated signaling by LMW-DSP2Q24320250
Deciphering the molecular landscape in chronic lymphocytic leukemia: time frame of disease evolutionQ26823586
From fly wings to targeted cancer therapies: a centennial for notch signalingQ27004534
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activationQ27851655
Recurrent mutations refine prognosis in chronic lymphocytic leukemia.Q27853022
Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia.Q27853333
Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemiaQ28394721
CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organsQ28594485
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemiaQ29614659
JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.Q33648402
DNMT3A in haematological malignanciesQ34463554
Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's diseaseQ34522096
DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118.Q34612201
Monoclonal B-cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progressionQ34998866
The Notch signalling system: recent insights into the complexity of a conserved pathwayQ35206852
NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLLQ35794466
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemiaQ37113435
CCR7 expression alters memory CD8 T-cell homeostasis by regulating occupancy in IL-7- and IL-15-dependent nichesQ37126820
Prevalence and characteristics of central nervous system involvement by chronic lymphocytic leukemiaQ37216335
Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndromeQ37246532
Analysis of chronic lymphotic leukemia transcriptomic profile: differences between molecular subgroupsQ38511275
Richter syndrome: pathogenesis and managementQ38797098
Mutations driving CLL and their evolution in progression and relapseQ39714436
Ablation of Stat3 by siRNA alters gene expression profiles in JEG-3 cells: a systems biology approachQ39823459
De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.Q40453633
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.Q40683787
Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patientsQ40881581
Protein kinase CK2 regulates the dimerization of histone deacetylase 1 (HDAC1) and HDAC2 during mitosisQ42144052
Prognostic impact and landscape of NOTCH1 mutations in chronic lymphocytic leukemia (CLL): a study on 852 patientsQ43555954
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanismQ43607424
Functional impact of NOTCH1 mutations in chronic lymphocytic leukemiaQ46339557
CIP4 controls CCL19-driven cell steering and chemotaxis in chronic lymphocytic leukemia.Q51019240
NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: evidence for a NOTCH1 mutation-driven epigenetic dysregulation.Q52931736
NOTCH1 mutations identify a genetic subgroup of chronic lymphocytic leukemia patients with high risk of transformation and poor outcome.Q53259951
The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting.Q53271932
HDAC1/DNMT3A-containing complex is associated with suppression of Oct4 in cervical cancer cells.Q53854927
Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features.Q54409071
Analysis of migratory and prosurvival pathways induced by the homeostatic chemokines CCL19 and CCL21 in B-cell chronic lymphocytic leukemia.Q54672999
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cellsQ81974229
P433issue9
P921main subjectchronic lymphocytic leukemiaQ1088156
lymphocyteQ715347
leukemiaQ29496
P304page(s)1882-1893
P577publication date2016-12-26
P1433published inLeukemiaQ6534498
P1476titleMutations in NOTCH1 PEST-domain orchestrate CCL19-driven homing of Chronic Lymphocytic Leukemia cells by modulating the tumor suppressor gene DUSP22.
P478volume31