Evidence for biased agonists and antagonists at the endothelin receptors

scientific article published on 17 February 2016

Evidence for biased agonists and antagonists at the endothelin receptors is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.LFS.2016.02.069
P932PMC publication ID5000545
P698PubMed publication ID26898124

P50authorJanet J. MaguireQ51749680
P2093author name stringJanet J Maguire
P2860cites workIRL-1620, a tumor selective vasodilator, augments the uptake and efficacy of chemotherapeutic agents in prostate tumor ratsQ79890365
Biased Agonism of the Angiotensin II Type I ReceptorQ26801071
ETA receptor‐mediated constrictor responses to endothelin peptides in human blood vessels in vitroQ28367973
Essential role of sympathetic endothelin A receptors for adverse cardiac remodelingQ34217961
β-Arrestins regulate human cardiac fibroblast transformation and collagen synthesis in adverse ventricular remodelingQ34603394
Endothelin-1/endothelin A receptor-mediated biased signaling is a new player in modulating human ovarian cancer cell tumorigenesis.Q34624192
Clinical trials with endothelin receptor antagonists: what went wrong and where can we improve?Q34660839
Development and characterization of pepducins as Gs-biased allosteric agonistsQ34774416
A cell permeable peptide targeting the intracellular loop 2 of endothelin B receptor reduces pulmonary hypertension in a hypoxic rat modelQ35060505
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signalingQ35201347
Arrestins 2 and 3 differentially regulate ETA and P2Y2 receptor-mediated cell signaling and migration in arterial smooth muscle.Q35849415
Endothelin receptors in human coronary artery and aortaQ35873397
Failure of BQ123, a more potent antagonist of sarafotoxin 6b than of endothelin-1, to distinguish between these agonists in binding experimentsQ35873739
Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasisQ37115261
Recent developments in biased agonismQ38200333
β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells.Q39023562
Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy.Q39040325
ETA-receptor antagonists or allosteric modulators?Q39761886
Characterization of the endothelin receptor selective agonist, BQ3020 and antagonists BQ123, FR139317, BQ788, 50235, Ro462005 and bosentan in the heart.Q41972819
Endothelin-1 and endothelin-2 initiate and maintain contractile responses by different mechanisms in rat mesenteric and cerebral arteriesQ41974344
Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonistQ42283587
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteersQ42705103
Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor.Q44329832
Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissuesQ44547639
β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.Q44686499
Comparison of human ETA and ETB receptor signalling via G-protein and β-arrestin pathwaysQ44767788
Endothelin B receptor agonist, IRL-1620, enhances angiogenesis and neurogenesis following cerebral ischemia in ratsQ46986382
What is pharmacological 'affinity'? Relevance to biased agonism and antagonism.Q53149817
G protein-coupled receptor modulation with pepducins: moving closer to the clinicQ56648575
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmembrane proteinQ423042
cell surface receptorQ2476074
mechanism of actionQ3271540
P304page(s)30-33
P577publication date2016-02-17
2016-08-15
P1433published inLife SciencesQ5256275
P1476titleEvidence for biased agonists and antagonists at the endothelin receptors
P478volume159

Reverse relations

cites work (P2860)
Q38734780Endothelin-1 receptor blockade as new possible therapeutic approach in multiple myeloma.
Q39458009Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?
Q89590039Ovarian hormones modulate endothelin-1 receptor responses in young women

Search more.