Cyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells.

scientific article published on 7 June 2016

Cyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.18632/ONCOTARGET.9901
P932PMC publication ID5216717
P698PubMed publication ID27286258

P50authorBrigitte SolaQ42638665
Olivier HéraultQ60142572
Fabrice GouilleuxQ84216569
P2093author name stringSimon Body
Jérôme Bourgeais
Sophie Bustany
Guergana Tchakarska
P2860cites workCyclin D1 interacts and collaborates with Ral GTPases enhancing cell detachment and motilityQ24337518
PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1bQ24610494
Molecular pathogenesis of multiple myeloma: basic and clinical updatesQ27026205
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiologyQ27860991
Cyclin D as a therapeutic target in cancerQ28242623
Cyclin D1 functions in cell migrationQ28274139
Targeting MUC1-C is synergistic with bortezomib in downregulating TIGAR and inducing ROS-mediated myeloma cell deathQ33585280
Mitochondrial thioredoxin reductase regulates major cytotoxicity pathways of proteasome inhibitors in multiple myeloma cells.Q33701777
NADPH oxidases regulate cell growth and migration in myeloid cells transformed by oncogenic tyrosine kinasesQ33834313
New Strategies in the Treatment of Multiple MyelomaQ33958520
G1 cell-cycle control and cancerQ34368858
The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myelomaQ34448863
Cyclin D1 determines mitochondrial function in vivoQ35070938
Cyclin D1 governs adhesion and motility of macrophagesQ35153599
Synergistic Activity of Carfilzomib and Panobinostat in Multiple Myeloma Cells via Modulation of ROS Generation and ERK1/2.Q35592352
Cyclin D1 sensitizes myeloma cells to endoplasmic reticulum stress-mediated apoptosis by activating the unfolded protein response pathwayQ35604566
Cyclin D dysregulation: an early and unifying pathogenic event in multiple myelomaQ35847805
Redox regulation of cell migration and adhesionQ35889032
Potent activity of carfilzomib, a novel, irreversible inhibitor of the ubiquitin-proteasome pathway, against preclinical models of multiple myelomaQ36384889
Senescence-associated secretory phenotype favors the emergence of cancer stem-like cells.Q36525196
Redox regulation and its emerging roles in stem cells and stem-like cancer cellsQ37322470
Pathogenesis of MyelomaQ37831905
Manipulation of cellular redox parameters for improving therapeutic responses in B‐cell lymphoma and multiple myelomaQ37940343
MEK inhibitors as a chemotherapeutic intervention in multiple myelomaQ38092584
Therapeutic advancements in multiple myelomaQ38252583
Targeting the bone marrow microenvironment in multiple myeloma.Q38289041
Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cellsQ38355225
Inhibition of thioredoxin 1 leads to apoptosis in drug-resistant multiple myelomaQ38878577
Adhesion to fibronectin induces p27(Kip1) nuclear accumulation through down-regulation of Jab1 and contributes to cell adhesion-mediated drug resistance (CAM-DR) in RPMI 8,226 cellsQ39068932
Sorafenib inhibits cell migration and stroma-mediated bortezomib resistance by interfering B-cell receptor signaling and protein translation in mantle cell lymphomaQ39227871
Immunomodulatory drugs lenalidomide and pomalidomide inhibit multiple myeloma-induced osteoclast formation and the RANKL/OPG ratio in the myeloma microenvironment targeting the expression of adhesion moleculesQ39239701
Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathwayQ39392738
Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasionQ39562168
Cyclin D1 Inhibits Mitochondrial Activity in B CellsQ39587826
Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cellsQ39736048
Bortezomib overcomes cell-adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myelomaQ39930099
Alternate cyclin D1 mRNA splicing modulates p27KIP1 binding and cell migrationQ40027619
Cyclin D1 induction of cellular migration requires p27(KIP1).Q40218988
Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitorsQ40550020
Cell adhesion mediated drug resistance (CAM-DR): role of integrins and resistance to apoptosis in human myeloma cell linesQ41328166
Cyclin D1 localizes in the cytoplasm of keratinocytes during skin differentiation and regulates cell–matrix adhesionQ42866996
Redox homeostasis modulates the sensitivity of myeloma cells to bortezomibQ43806000
PRIMA-1Met induces myeloma cell death independent of p53 by impairing the GSH/ROS balanceQ46868792
Adhesion to fibronectin via beta1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR).Q52540929
Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation.Q54775097
Occurrence of cytochrome b558 in B-cell lineage of human lymphocytesQ68446886
Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activityQ79273390
P433issue29
P407language of work or nameEnglishQ1860
P921main subjectdrug resistanceQ12147416
cell adhesionQ187640
cell migrationQ189092
P304page(s)45214-45224
P577publication date2016-07-01
P1433published inOncotargetQ1573155
P1476titleCyclin D1 unbalances the redox status controlling cell adhesion, migration, and drug resistance in myeloma cells
P478volume7

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cites work (P2860)
Q97692648Cyclin D1 targets hexokinase 2 to control aerobic glycolysis in myeloma cells
Q50330020Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance
Q50287987In vitro and in vivo cytotoxic effect of AntiGan against tumor cells
Q39185604Mechanisms of Resistance in Multiple Myeloma
Q55091606Soluble and Cell-Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma.
Q59797793Targeted Therapy-Resistant Melanoma Cells Acquire Transcriptomic Similarities with Human Melanoblasts
Q49732981Transcription activated p73-modulated cyclin D1 expression leads to doxorubicin resistance in gastric cancer

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