Bcl-2 proteins and calcium signaling: complexity beneath the surface

scientific article published on 14 March 2016

Bcl-2 proteins and calcium signaling: complexity beneath the surface is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1011489212
P356DOI10.1038/ONC.2016.31
P698PubMed publication ID26973249

P50authorJan B. ParysQ38324881
P2093author name stringG Bultynck
T Vervliet
P2860cites workBcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store contentQ44570171
Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosisQ45000461
The voltage-dependent anion channel-1 modulates apoptotic cell death.Q46428272
The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effectQ46794468
Displacement of SERCA from SR lipid caveolae-related domains by Bcl-2: a possible mechanism for SERCA inactivationQ46875789
Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescenceQ46897923
Ca2+ entry through plasma membrane IP3 receptors.Q48546959
Bcl-2 binds to and inhibits ryanodine receptorsQ49073617
The mitochondrial channel VDAC has a cation-selective open stateQ63027354
Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosisQ64378995
Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ storesQ64379412
Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondriaQ72593109
Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet functionQ83394569
The IP3 receptor as a hub for Bcl-2 family proteins in cell death control and beyondQ87273757
Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptorQ87432187
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDACQ22009974
Bcl-2 family interaction with the mitochondrial morphogenesis machineryQ24293601
Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancerQ24299726
Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctionsQ24306442
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporterQ24306825
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporterQ24306850
The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4Q24309225
Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxesQ24313314
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeastQ24314476
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligandsQ24321449
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family membersQ24337108
Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer TherapyQ24337757
Human Golgi antiapoptotic protein modulates intracellular calcium fluxesQ24339130
BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell deathQ24680305
Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletionQ24684783
Inositol 1,4,5-trisphosphate receptor-isoform diversity in cell death and survivalQ26825354
Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM)Q26862963
When ER stress reaches a dead endQ26998580
Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stressQ27006876
The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell deathQ27012559
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing plateletsQ27683708
The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavageQ28115007
Ca2+-induced apoptosis through calcineurin dephosphorylation of BADQ28140882
A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2.Q36413780
Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulumQ36490197
T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosisQ36568483
Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release.Q36609490
Bax Inhibitor-1 Is a pH-dependent regulator of Ca2+ channel activity in the endoplasmic reticulumQ36701864
Functions of BCL-X L at the Interface between Cell Death and MetabolismQ36702748
Calcium-ATPases: Gene disorders and dysregulation in cancerQ36854038
Calcium and cancer: targeting Ca2+ transportQ36856463
Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosisQ36902982
IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2.Q36907071
NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL.Q36963944
An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptakeQ37000616
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?Q37100016
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survivalQ37146087
Bcl-2 suppresses sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell deathQ37175235
Bcl-x L increases mitochondrial fission, fusion, and biomass in neuronsQ37202353
Uncovering the role of VDAC in the regulation of cell life and deathQ37225440
The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptorQ37308429
Bcl-2 family proteins and cancerQ37310180
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosisQ37310184
Control of mitochondrial apoptosis by the Bcl-2 familyQ37385623
Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors.Q37409477
Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survivalQ37519743
Emerging role for members of the Bcl-2 family in mitochondrial morphogenesisQ37633650
Mitochondrial fusion proteins: dual regulators of morphology and metabolismQ37676501
Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.Q37699891
Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensorQ37700695
VDAC, a multi-functional mitochondrial protein regulating cell life and deathQ37719811
Apoptosis and autophagy: decoding calcium signals that mediate life or deathQ37786444
Apoptosis and oncogenesis: give and take in the BCL-2 familyQ37828794
Organellar calcium buffersQ37855346
Endoplasmic-reticulum calcium depletion and diseaseQ37858336
The Ca2+ pumps of the endoplasmic reticulum and Golgi apparatus.Q37858339
Bax inhibitor-1: a highly conserved endoplasmic reticulum-resident cell death suppressor.Q37877541
The ancient cell death suppressor BAX inhibitor-1.Q37887929
Endoplasmic reticulum calcium pumps and cancerQ37889807
Plasma membrane calcium ATPases and cancer.Q37889808
Calcium in tumour metastasis: new roles for known actors.Q37903657
The ER-mitochondria interface: the social network of cell deathQ37969854
Inositol 1,4,5-trisphosphate and its receptors.Q37997677
Mitochondria-associated membranes (MAMs) as hotspot Ca(2+) signaling unitsQ37997685
Mitochondrial Ca(2+) and apoptosisQ38000429
Targeting the B-cell lymphoma/leukemia 2 family in cancerQ38014808
Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3Q28246420
Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calciumQ28287491
Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generationQ28397854
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulumQ28506206
BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stressQ28507379
Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neuronsQ28576002
In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell deathQ28576382
Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membraneQ28580739
Intracellular localization of the BCL-2 family member BOK and functional implicationsQ28586794
ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout miceQ28587474
Role of Bax and Bak in mitochondrial morphogenesisQ28591724
Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblastsQ28592323
BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stressQ28592598
TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasisQ28594126
Mitochondrial membrane permeabilization in cell deathQ29547425
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
Mitochondria and cell death: outer membrane permeabilization and beyondQ29615459
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosisQ29620466
HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.Q30454476
Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosisQ30496802
hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2Q30543225
Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.Q30554728
BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activationQ33395270
Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of plateletsQ33395784
Voltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activityQ33673430
Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signalingQ33810050
Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondriaQ33890261
Inositol trisphosphate receptor Ca2+ release channels.Q33983069
Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.Q34016676
Ryanodine receptors: structure, expression, molecular details, and function in calcium release.Q34024377
Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptorsQ34075849
The IP(3) receptor-mitochondria connection in apoptosis and autophagyQ34154125
Functional SNP in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcificationQ34205590
TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survivalQ34218298
The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.Q34236873
A novel role for Bcl-2 in regulation of cellular calcium extrusionQ39330267
Type 1 inositol-1,4,5-trisphosphate receptor is a late substrate of caspases during apoptosisQ39369740
Heat-shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca2+-mediated apoptosisQ39391422
ORAI1-mediated calcium influx in lactation and in breast cancerQ39609150
Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.Q39676476
The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins.Q39848298
Orai1 and STIM1 are critical for breast tumor cell migration and metastasisQ39888627
Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.Q40007779
TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways.Q40126939
The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3RQ40369800
The regulatory domain of the inositol 1,4,5-trisphosphate receptor is necessary to keep the channel domain closed: possible physiological significance of specific cleavage by caspase 3.Q40635461
Degradation of the type I inositol 1,4,5-trisphosphate receptor by caspase-3 in SH-SY5Y neuroblastoma cells undergoing apoptosisQ40848960
Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signalsQ40894970
Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent mannerQ40917301
NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosisQ40943000
Modulation of endoplasmic reticulum calcium pump by Bcl-2.Q41000205
Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.Q41432708
Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein productionQ41565273
Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulumQ41889229
Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gatingQ42067925
Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing proteinQ42323253
Autosis: a new addition to the cell death Tower of BabelQ42771774
Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).Q42808518
Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.Q42919140
Cardiolipin, phosphatidylserine, and BH4 domain of Bcl-2 family regulate Ca2+/H+ antiporter activity of human Bax inhibitor-1.Q43145763
Antagonizing Bcl-2's BH4 domain in cancerQ43184271
Evidence for a role of the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase in thapsigargin and Bcl-2 induced changes in Xenopus laevis oocyte maturationQ43583417
Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late eventQ43613062
Regulation of sodium-calcium exchange and mitochondrial energetics by Bcl-2 in the heart of transgenic miceQ43816860
Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteinsQ44246042
Molecular identity and functional properties of the mitochondrial Na+/Ca2+ exchangerQ38028454
Mitochondria as sensors and regulators of calcium signallingQ38031124
The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyondQ38041423
The contribution of the sodium-calcium exchanger (NCX) and plasma membrane Ca(2+) ATPase (PMCA) to cerebellar synapse functionQ38066052
Altered Ca(2+) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors.Q38066674
Non-apoptotic roles of Bcl-2 family: the calcium connectionQ38077641
The plasma membrane calcium pump in health and diseaseQ38081907
TRP channelsQ38111283
The endoplasmic reticulum-mitochondria connection: one touch, multiple functions.Q38161252
TMBIM protein family: ancestral regulators of cell deathQ38190369
The plasma membrane calcium pump: new ways to look at an old enzyme.Q38191170
Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatmentQ38197005
A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulumQ38207368
The plethora of PMCA isoforms: Alternative splicing and differential expressionQ38298931
Mitochondria-associated membranes: composition, molecular mechanisms, and physiopathological implicationsQ38306819
Calcium signaling at ER membrane contact sitesQ38348273
Toxins targeting voltage-activated Ca2+ channels and their potential biomedical applicationsQ38365089
Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulationQ38502062
Novel frontiers in calcium signaling: A possible target for chemotherapyQ38509835
Molecular structure and function of P2X receptors.Q38558625
Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.Q38626077
Mitochondria associated membranes (MAMs) as critical hubs for apoptosisQ38636161
Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular FunctionQ38669205
CRAC channels, calcium, and cancer in light of the driver and passenger conceptQ38679841
Multifaceted plasma membrane Ca(2+) pumps: From structure to intracellular Ca(2+) handling and cancerQ38680255
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca(2+) signalingQ38698170
Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263.Q38807526
Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in CancerQ38807596
HA14-1 potentiates apoptosis in B-cell cancer cells sensitive to a peptide disrupting IP 3 receptor / Bcl-2 complexesQ38844722
Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domainQ38887404
Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity.Q39016220
BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteinsQ39261543
A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.Q39283973
The organisation and functions of local Ca(2+) signals.Q34330244
The versatility and complexity of calcium signallingQ34350681
Mitochondrial Ca(2+) influx targets cardiolipin to disintegrate respiratory chain complex II for cell death inductionQ34413466
The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.Q34466854
Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interactionQ34707190
Bcl2's flexible loop domain regulates p53 binding and survivalQ34718151
Ryanodine receptor calcium release channelsQ34882627
Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptorQ35020243
The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release.Q35172714
Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signalingQ35176330
Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interfaceQ35226850
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.Q35250940
Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distanceQ35566958
The BCL-2 family reunionQ35568029
The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.Q35580876
Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transportQ35663795
VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria.Q35687111
Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.Q35687120
The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channelQ35733253
Bcl-2 and calcium: controversy beneath the surfaceQ35743131
IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditionsQ35821598
Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.Q35880175
Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.Q35928022
The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel functionQ36042455
Mitochondrial Ca(2+) signals in autophagy.Q36074837
Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 proteinQ36080596
Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activationQ36116776
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.Q36119444
STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer MetastasisQ36122589
Calcium channels and pumps in cancer: changes and consequencesQ36234684
Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2Q36254782
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.Q36322335
Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell deathQ36412965
P433issue39
P407language of work or nameEnglishQ1860
P304page(s)5079-5092
P577publication date2016-03-14
P1433published inOncogeneQ1568657
P1476titleBcl-2 proteins and calcium signaling: complexity beneath the surface
P478volume35

Reverse relations

cites work (P2860)
Q47409394A double point mutation at residues Ile14 and Val15 of Bcl-2 uncovers a role for the BH4 domain in both protein stability and function
Q60480019ABT-199 (Venetoclax), a BH3-mimetic Bcl-2 inhibitor, does not cause Ca2+ -signalling dysregulation or toxicity in pancreatic acinar cells
Q47942948Alterations in Ca2+ Signalling via ER-Mitochondria Contact Site Remodelling in Cancer
Q92941311Anti-Cancer Agents in Proliferation and Cell Death: The Calcium Connection
Q94570482Anti-apoptosis effect of heme oxygenase-1 on lung injury after cardiopulmonary bypass
Q99564758BDA-366, a putative Bcl-2 BH4 domain antagonist, induces apoptosis independently of Bcl-2 in a variety of cancer cell models
Q41914212BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides
Q93117054Bcl-2 and IP3 compete for the ligand-binding domain of IP3Rs modulating Ca2+ signaling output
Q64026764Constitutive IP signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP receptor disruptor BIRD-2
Q39112253Crosstalk between calcium and reactive oxygen species signaling in cancer.
Q92811394Dysregulated Interorganellar Crosstalk of Mitochondria in the Pathogenesis of Parkinson's Disease
Q51737093Emerging molecular mechanisms in chemotherapy: Ca2+ signaling at the mitochondria-associated endoplasmic reticulum membranes.
Q88210359IP3 Receptor Properties and Function at Membrane Contact Sites
Q39446526IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer
Q99551786Mechanism of transmembrane and coiled-coil domain 1 in the regulation of proliferation and migration of A549 cells
Q48101786MicroRNA-200a induces apoptosis by targeting ZEB2 in alcoholic liver disease.
Q91045649Mitochondria damaged by Oxygen Glucose Deprivation can be Restored through Activation of the PI3K/Akt Pathway and Inhibition of Calcium Influx by Amlodipine Camsylate
Q97526682Mitophagy, Mitochondrial Homeostasis, and Cell Fate
Q39313975Modulation of Ca2+ Signaling by Anti-apoptotic B-Cell Lymphoma 2 Proteins at the Endoplasmic Reticulum-Mitochondrial Interface.
Q47843948Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Q37607813Of yeast, mice and men: MAMs come in two flavors.
Q42084376On BH3 Mimetics and Ca2+ Signaling.
Q42620650Organelle membrane derived patches: reshaping classical methods for new targets
Q47943098Over Six Decades of Discovery and Characterization of the Architecture at Mitochondria-Associated Membranes (MAMs).
Q92328222Partners in Crime: Towards New Ways of Targeting Calcium Channels
Q47716556Post-Transcriptional Regulation of Anti-Apoptotic BCL2 Family Members
Q33849385Protein Lipidation As a Regulator of Apoptotic Calcium Release: Relevance to Cancer.
Q41009828Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation.
Q89729975Rapamycin inhibits B-cell activating factor (BAFF)-stimulated cell proliferation and survival by suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway in normal and neoplastic B-lymphoid cells
Q61813971Recent advances in uncovering the mechanisms contributing to BIRD-2-induced cell death in B-cell cancer cells
Q50017171Reciprocal sensitivity of diffuse large B-cell lymphoma cells to Bcl-2 inhibitors BIRD-2 versus venetoclax
Q53827160Role of Mitochondria-Associated ER Membranes in Calcium Regulation in Cancer-Specific Settings.
Q54974646Ryanodine Receptors in Autophagy: Implications for Neurodegenerative Diseases?
Q39073603TMBIM-mediated Ca2+ homeostasis and cell death
Q93043730TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit
Q90573731Targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones
Q41366716The Regulation of Tumor Cell Invasion and Metastasis by Endoplasmic Reticulum-to-Mitochondrial Ca2+ Transfer
Q39249695The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics
Q39225329The calcium-cancer signalling nexus.
Q52671146Wolfram syndrome: MAMs' connection?
Q57072924β-Arrestin 2 Promotes Hepatocyte Apoptosis by Inhibiting Akt Pathway in Alcoholic Liver Disease

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