Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma

scientific article published on 15 April 2016

Unique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1016010360
P356DOI10.1038/SREP24578
P932PMC publication ID4832330
P698PubMed publication ID27080907

P50authorRavi SalgiaQ73567837
Qudsia ArifQ113027590
Rajani KantetiQ113027596
P2093author name stringJames K Liao
Jacob J Riehm
Frances E Lennon
Martin Sattler
Hedy L Kindler
Aliya Husain
Gianguido C Cianci
Valeriy A Poroyko
Eitan Lupovitch
Phetcharat Chen
Wickii Vigneswaran
P2860cites workFis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fissionQ24307570
An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2Q24311384
Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fissionQ24315659
Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1Q24317456
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysisQ24337960
Germline BAP1 mutations predispose to malignant mesotheliomaQ24635326
Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic reviewQ26850912
Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant MesotheliomaQ27306784
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Proteomic characterization of non-small cell lung cancer in a comprehensive translational thoracic oncology databaseQ28391454
Impaired balance of mitochondrial fission and fusion in Alzheimer's diseaseQ28854335
Paxillin mutations affect focal adhesions and lead to altered mitochondrial dynamics: relevance to lung cancerQ30542819
Metabolic stress regulates cytoskeletal dynamics and metastasis of cancer cellsQ30576959
Heterogeneity of mitochondria and mitochondrial function within cells as another level of mitochondrial complexityQ33452558
Mitochondrial dynamics regulates hypoxia-induced migration and antineoplastic activity of cisplatin in breast cancer cellsQ39092538
Fractal dimension as a measure of altered actin cytoskeleton in MC3T3-E1 cells under simulated microgravity using 3-D/2-D clinostatsQ39394288
Self-similarity and fractal irregularity in pathologic tissuesQ41018602
Fractals in pathologyQ41534922
Bioenergetic differences between MCF-7 and T47D breast cancer cells and their regulation by oestradiol and tamoxifen.Q51693448
Whole-exome sequencing reveals frequent genetic alterations in BAP1, NF2, CDKN2A, and CUL1 in malignant pleural mesothelioma.Q54303280
Mitochondria (and other cytoplasmic structures) in tissue culturesQ55967225
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Neurofibromatosis type 2 (NF2) gene is somatically mutated in mesothelioma but not in lung cancerQ72610940
Malignant pleural mesotheliomaQ83412919
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Metformin decreases lung cancer risk in diabetic patients in a dose-dependent mannerQ85650990
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesisQ33597162
Bioenergetic analysis of ovarian cancer cell lines: profiling of histological subtypes and identification of a mitochondria-defective cell lineQ33655175
Fractal characteristics of May-Grünwald-Giemsa stained chromatin are independent prognostic factors for survival in multiple myeloma.Q33941055
Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confoundersQ34135248
MET and PI3K/mTOR as a potential combinatorial therapeutic target in malignant pleural mesotheliomaQ34182679
Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationshipQ34193347
Fractal methods and results in cellular morphology--dimensions, lacunarity and multifractalsQ34409645
Novel roles for actin in mitochondrial fissionQ34433432
The established and future biomarkers of malignant pleural mesotheliomaQ34476612
GSK3beta-mediated Drp1 phosphorylation induced elongated mitochondrial morphology against oxidative stressQ34489873
Lacunarity analysis: A general technique for the analysis of spatial patternsQ34491840
TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expressionQ34532535
Mitochondrial dynamics and inheritance during cell division, development and diseaseQ34600662
Metformin--mode of action and clinical implications for diabetes and cancerQ34658712
Metformin use and lung cancer risk in patients with diabetes.Q35046673
Alpha-enolase promotes cell glycolysis, growth, migration, and invasion in non-small cell lung cancer through FAK-mediated PI3K/AKT pathwayQ35177876
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumorsQ35289071
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancerQ35913045
Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissueQ35954906
Running with neighbors: coordinating cell migration and cell-cell adhesionQ36264688
A fractal model for nuclear organization: current evidence and biological implicationsQ36305576
Quantitating the subtleties of microglial morphology with fractal analysisQ36572876
VS-5584, a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancerQ36656352
Malignant pleural mesothelioma: update on treatment options with a focus on novel therapies.Q36728254
Euclidean and fractal geometry of microvascular networks in normal and neoplastic pituitary tissueQ37104748
Mitochondrial dynamics regulates migration and invasion of breast cancer cellsQ37548419
The fractal geometry of life.Q37589528
Malignant pleural mesothelioma: factors influencing the prognosis.Q38081894
Determining the shape and cellular distribution of mitochondria: the integration of multiple activitiesQ38089365
Molecular pathogenesis of malignant mesotheliomaQ38107102
How does cancer cell metabolism affect tumor migration and invasion?Q38153177
Immune checkpoint blockade in malignant mesotheliomaQ38475077
Pleural neoplastic pathologyQ38517565
Expanding the therapeutic spectrum of metformin: from diabetes to cancer.Q38558943
Marker-free phenotyping of tumor cells by fractal analysis of reflection interference contrast microscopy imagesQ39089894
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)24578
P577publication date2016-04-15
P1433published inScientific ReportsQ2261792
P1476titleUnique fractal evaluation and therapeutic implications of mitochondrial morphology in malignant mesothelioma
P478volume6

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cites work (P2860)
Q38810383Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins
Q58612417Deep Analysis of Mitochondria and Cell Health Using Machine Learning
Q52692095Dynamin-Related Protein 1 at the Crossroads of Cancer.
Q57470547Inhibiting crosstalk between MET signaling and mitochondrial dynamics and morphology: a novel therapeutic approach for lung cancer and mesothelioma
Q101216897Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology
Q39084933Mitochondrial dynamics as regulators of cancer biology
Q47871739Mitochondrial network complexity emerges from fission/fusion dynamics
Q91962309Small Cell Lung Cancer Therapeutic Responses Through Fractal Measurements: From Radiology to Mitochondrial Biology
Q33711227The Concerted Action of Mitochondrial Dynamics and Positioning: New Characters in Cancer Onset and Progression.
Q42202308Universal fractality of morphological transitions in stochastic growth processes

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