Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system

scientific article published on 25 April 2017

Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1085415817
P356DOI10.1038/IJO.2017.98
P932PMC publication ID5550563
P698PubMed publication ID28507313

P50authorBolette HartmannQ51055821
Katrin KainederQ64495799
Selma MautnerQ90224789
Signe Sørensen TorekovQ38548255
P2093author name stringJ Eichler
T R Pieber
B Obermüller
G Rauter
J Münzker
P Kotzbeck
T Birngruber
W Al-Zoughbi
P2860cites workTransfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetesQ58447447
The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humansQ58448806
Glucagon-like Peptide-1 receptor signaling in the lateral parabrachial nucleus contributes to the control of food intake and motivation to feedQ41816012
Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese miceQ42004480
Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat.Q42445138
Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathwayQ42492353
Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humansQ42612217
Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weightQ42936904
Melanocortin activity in the amygdala controls appetite for dietary fat.Q43239280
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One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.Q44865459
GLP-1 agonism stimulates brown adipose tissue thermogenesis and browning through hypothalamic AMPK.Q46088562
Effects of changes in body weight on carbohydrate metabolism, catecholamine excretion, and thyroid functionQ47237643
Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat.Q47273005
Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats.Q47295180
Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not.Q47308234
Liraglutide: short-lived effect on gastric emptying -- long lasting effects on body weightQ47333623
Long-term persistence of hormonal adaptations to weight lossQ47347342
Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in ratsQ47385994
Gene expression of pro-opiomelanocortin and melanocortin receptors is regulated in the hypothalamus and mesocorticolimbic system following nicotine administrationQ48415551
Central administration of GLP-1-(7-36) amide inhibits food and water intake in ratsQ48905629
A role for glucagon-like peptide-1 in the central regulation of feedingQ24314317
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Melanocortin 4 receptor activates ERK-cFos pathway to increase brain-derived neurotrophic factor expression in rat astrocytes and hypothalamusQ28260767
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and humanQ29617382
Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effectQ30412673
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight lossQ30596646
Quantification of adiposity in small rodents using micro-CTQ33635804
Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adultsQ33737073
Differences in acute anorectic effects of long-acting GLP-1 receptor agonists in rats.Q33959406
Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]Q34089543
Brown and beige fat: development, function and therapeutic potentialQ34375850
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in miceQ34428994
Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss.Q34665186
Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4.Q35110843
Long-term implanted cOFM probe causes minimal tissue reaction in the brainQ35118715
Leptin reverses declines in satiation in weight-reduced obese humansQ35677267
GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intakeQ35744558
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesityQ35768964
Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signalingQ36339639
Adaptive thermogenesis in humansQ36905606
Liraglutide for Type 2 diabetes and obesity: a 2015 updateQ38536672
Successful weight loss maintenance includes long-term increased meal responses of GLP-1 and PYY3-36.Q39921099
Differential effects of melanocortin peptides on neural melanocortin receptors.Q41421476
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectweight gainQ3403879
P304page(s)1263-1270
P577publication date2017-04-25
P1433published inInternational Journal of ObesityQ6051519
P1476titleChronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system
P478volume41

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