Modifying the tumor microenvironment using nanoparticle therapeutics

scientific article published on April 2016

Modifying the tumor microenvironment using nanoparticle therapeutics is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/WNAN.1406
P932PMC publication ID5045752
P698PubMed publication ID27038329

P50authorAniruddha RoyQ84042462
P2093author name stringShyh-Dar Li
P2860cites workUsing anti-VEGF McAb and magnetic nanoparticles as double-targeting vector for the radioimmunotherapy of liver cancerQ82203646
Identification and characterization of cancer stem-like cells from primary carcinoma of the cervix uteriQ84593185
Cancer stem cellsQ84976114
Polyelectrolyte Multilayers Assembled Entirely from Immune Signals on Gold Nanoparticle Templates Promote Antigen-Specific T Cell ResponseQ85278186
Vascular endothelial growth factor selectively targets boronated dendrimers to tumor vasculatureQ40388042
Penetration of endothelial cell coated multicellular tumor spheroids by iron oxide nanoparticlesQ40578734
Modulation of tumor cell response to chemotherapy by the organ environmentQ40630947
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reactionQ40964604
Poly(anhydride) nanoparticles act as active Th1 adjuvants through Toll-like receptor exploitationQ42117985
Integrins in tumor angiogenesis and lymphangiogenesisQ42263292
Peptide-conjugated biodegradable nanoparticles as a carrier to target paclitaxel to tumor neovasculatureQ43201316
Targeting of tumor endothelium by RGD-grafted PLGA-nanoparticles loaded with paclitaxelQ43287891
Tumor regression by targeted gene delivery to the neovasculatureQ44044889
Self-assembled nanoparticles based on glycol chitosan bearing 5beta-cholanic acid for RGD peptide deliveryQ44801047
CD44 antibody-targeted liposomal nanoparticles for molecular imaging and therapy of hepatocellular carcinoma.Q45878473
Tumor angiogenesis: a new significant and independent prognostic indicator in early-stage breast carcinomaQ45952675
CD133+CD44+ population efficiently enriches colon cancer initiating cellsQ46457938
Detection of tumor angiogenesis in vivo by alphaVbeta3-targeted magnetic resonance imagingQ46789795
The eradication of breast cancer cells and stem cells by 8-hydroxyquinoline-loaded hyaluronan modified mesoporous silica nanoparticle-supported lipid bilayers containing docetaxel.Q51797622
Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo.Q54327891
Molecular interactions of the intrinsic activation complex of coagulation: binding of native and activated human factors IX and X to defined phospholipid vesiclesQ68813838
Plasma cortisol and testosterone in hypercholesterolaemia treated with clofibrate and lovastatinQ69541813
Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent modelsQ73365474
Magnetic resonance contrast enhancement of neovasculature with alpha(v)beta(3)-targeted nanoparticlesQ74280205
SPARC inhibits endothelial cell adhesion but not proliferation through a tyrosine phosphorylation-dependent pathwayQ77123766
Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapyQ79286234
Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinomaQ79600998
Nanotechnology-mediated targeting of tumor angiogenesisQ21195857
Salinomycin as a drug for targeting human cancer stem cellsQ21285139
Two RGD-independent alpha vbeta 3 integrin binding sites on tumstatin regulate distinct anti-tumor propertiesQ22254194
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcomeQ24657877
Prospective identification of tumorigenic breast cancer cellsQ24683474
Nanoparticle Drug Delivery Systems Designed to Improve Cancer Vaccines and ImmunotherapyQ26782566
Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasisQ26866144
Tensional homeostasis and the malignant phenotypeQ27860932
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healingQ28131793
Imaging and treating tumor vasculature with targeted radiolabeled carbon nanotubesQ28384090
Chemotherapeutics and radiation stimulate MHC class I expression through elevated interferon-beta signaling in breast cancer cellsQ28481351
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretionQ29547317
The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisitedQ29547915
Role of angiogenesis in tumor growth and metastasisQ29614309
Integrins in cancer: biological implications and therapeutic opportunitiesQ29614536
Microenvironmental regulation of tumor progression and metastasisQ29615504
Macrophage diversity enhances tumor progression and metastasisQ29615847
The extracellular matrix: a dynamic niche in cancer progressionQ29617793
Stromal fibroblasts in cancer initiation and progressionQ29618873
Detection of targeted perfluorocarbon nanoparticle binding using 19F diffusion weighted MR spectroscopyQ30488702
Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkersQ30542073
Vascular targeted single-walled carbon nanotubes for near-infrared light therapy of cancerQ31033802
Bladder cancer initiating cells (BCICs) are among EMA-CD44v6+ subset: novel methods for isolating undetermined cancer stem (initiating) cellsQ33349898
A nanoliposome delivery system to synergistically trigger TLR4 AND TLR7Q33583613
Cancer associated fibroblasts in cancer pathogenesisQ33664004
pH-Responsive nanoparticle vaccines for dual-delivery of antigens and immunostimulatory oligonucleotidesQ33703757
Biodistribution of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer drug deliveryQ33836864
Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.Q34164197
Chemotherapy enhances cross-presentation of nuclear tumor antigensQ34226903
F3-Targeted Cisplatin-Hydrogel Nanoparticles as an Effective Therapeutic That Targets Both Murine and Human Ovarian Tumor Endothelial Cells In vivoQ34268119
Tumor associated macrophages and neutrophils in tumor progressionQ34306107
Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblastsQ34358613
Distinct fibroblast lineages determine dermal architecture in skin development and repair.Q34391786
TLR-based immune adjuvants.Q34400322
iTEP nanoparticle-delivered salinomycin displays an enhanced toxicity to cancer stem cells in orthotopic breast tumors.Q34435742
Tumor angiogenesis and metastasis--correlation in invasive breast carcinomaQ34570747
Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations.Q34798776
TLR7 enables cross-presentation by multiple dendritic cell subsets through a type I IFN-dependent pathwayQ35220395
Targeting of metastasis-promoting tumor-associated fibroblasts and modulation of pancreatic tumor-associated stroma with a carboxymethylcellulose-docetaxel nanoparticleQ35537413
Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression.Q35538088
Tumor cells and tumor-associated macrophages: secreted proteins as potential targets for therapy.Q35582297
Selective inhibitory effect of HPMA copolymer-cyclopamine conjugate on prostate cancer stem cellsQ35624160
Docetaxel-carboxymethylcellulose nanoparticles target cells via a SPARC and albumin dependent mechanismQ35642480
Differential macrophage programming in the tumor microenvironmentQ35803027
SPARC and tumor growth: where the seed meets the soil?Q35813979
In vivo targeting and positron emission tomography imaging of tumor vasculature with (66)Ga-labeled nano-grapheneQ35854802
In vivo targeting and imaging of tumor vasculature with radiolabeled, antibody-conjugated nanographeneQ35856996
Cancer stem cells: impact, heterogeneity, and uncertaintyQ35857599
Nanoparticle and targeted systems for cancer therapyQ35879221
Nanoparticle modulation of the tumor microenvironment enhances therapeutic efficacy of cisplatinQ36217643
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrixQ36324827
Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vesselsQ36324866
Transformable Peptide Nanocarriers for Expeditious Drug Release and Effective Cancer Therapy via Cancer-Associated Fibroblast Activation.Q36531166
The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphomaQ36561226
Role of angiogenesis in human tumor dormancy: animal models of the angiogenic switchQ36576720
Tumor microenvironment: the role of the tumor stroma in cancerQ36709404
Nanoparticle-mediated drug delivery to tumor vasculature suppresses metastasisQ36756947
TLR agonists: our best frenemy in cancer immunotherapyQ36850457
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cellsQ37139993
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity.Q37207049
Targeted nanomedicine for suppression of CD44 and simultaneous cell death induction in ovarian cancer: an optimal delivery of siRNA and anticancer drugQ37356199
Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose.Q37377550
Biomimetic protein nanoparticles facilitate enhanced dendritic cell activation and cross-presentationQ37483316
Differential uptake of nanoparticles by endothelial cells through polyelectrolytes with affinity for caveolaeQ37612705
Targeting of tumor-associated macrophages made possible by PEG-sheddable, mannose-modified nanoparticlesQ37624646
Differential ability of surface and endosomal TLRs to induce CD8 T cell responses in vivoQ37728326
Nanoparticle-delivered transforming growth factor-β siRNA enhances vaccination against advanced melanoma by modifying tumor microenvironmentQ37731681
Tumor angiogenesis: molecular pathways and therapeutic targetsQ37953773
Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progressionQ37958688
RGD-based strategies to target alpha(v) beta(3) integrin in cancer therapy and diagnosisQ38042484
Application of polymeric nanoparticles in immunotherapyQ38055332
Tumor-associated macrophages: functional diversity, clinical significance, and open questionsQ38105286
Tumor-associated macrophages as major players in the tumor microenvironmentQ38240110
Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug deliveryQ38333122
Docetaxel conjugate nanoparticles that target α-smooth muscle actin-expressing stromal cells suppress breast cancer metastasis.Q38453301
Emerging therapies: angiogenesis inhibitors for ovarian cancerQ38497958
Nanoparticulate immunotherapy for cancerQ38598181
Co-delivery of platinum drug and siNotch1 with micelleplex for enhanced hepatocellular carcinoma therapy.Q38841311
Effect of Fe3O4 Nanoparticles on Skin Tumor Cells and Dermal Fibroblasts.Q38862293
CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer.Q38891812
In vivo delivery of peptides and Toll-like receptor ligands by mannose-functionalized polymeric nanoparticles induces prophylactic and therapeutic anti-tumor immune responses in a melanoma modelQ38931309
Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cellsQ38934297
Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells.Q38935837
Nanoparticle mediated co-delivery of paclitaxel and a TLR-4 agonist results in tumor regression and enhanced immune response in the tumor microenvironment of a mouse modelQ39200561
F3 peptide-functionalized PEG-PLA nanoparticles co-administrated with tLyp-1 peptide for anti-glioma drug deliveryQ39245838
Anticancer and immunostimulatory activity by conjugate of paclitaxel and non-toxic derivative of LPS for combined chemo-immunotherapy.Q39356108
A polymeric nanoparticle encapsulated small-molecule inhibitor of Hedgehog signaling (NanoHHI) bypasses secondary mutational resistance to Smoothened antagonistsQ39452730
Synthetic modification of carboxymethylcellulose and use thereof to prepare a nanoparticle forming conjugate of docetaxel for enhanced cytotoxicity against cancer cells.Q39455442
"Click" conjugation of peptide on the surface of polymeric nanoparticles for targeting tumor angiogenesisQ39581550
Combined cytotoxic and anti-invasive properties of redox-active nanoparticles in tumor-stroma interactions.Q39602327
Self-assembly nanoparticles for the delivery of bisphosphonates into tumorsQ39635176
Combined chemo-immunotherapy as a prospective strategy to combat cancer: a nanoparticle based approach.Q39658753
New self-assembly nanoparticles and stealth liposomes for the delivery of zoledronic acid: a comparative studyQ39730658
Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effectQ39754791
A novel DDS strategy, "dual-targeting", and its application for antineovascular therapyQ39823596
Identification of gastric cancer stem cells using the cell surface marker CD44.Q39856772
MR imaging of tumor angiogenesis using sterically stabilized Gd-DTPA liposomes targeted to CD105.Q39973836
Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograftQ40140782
P433issue6
P921main subjectnanoparticleQ61231
P304page(s)891-908
P577publication date2016-04-01
P1433published inWiley Interdisciplinary Reviews: Nanomedicine and NanobiotechnologyQ24056192
P1476titleModifying the tumor microenvironment using nanoparticle therapeutics
P478volume8

Reverse relations

cites work (P2860)
Q47417419Autonomous self-navigating drug-delivery vehicles: from science fiction to reality
Q64086221Cell membrane protein functionalization of nanoparticles as a new tumor-targeting strategy
Q92592099Nanoparticle Interactions with the Tumor Microenvironment
Q98771756Tumor Microenvironment in Ovarian Cancer: Function and Therapeutic Strategy

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