Cancer associated missense mutations in BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation

scientific article published on 18 December 2015

Cancer associated missense mutations in BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1005670226
P356DOI10.1038/SREP18462
P932PMC publication ID4683529
P698PubMed publication ID26680512
P5875ResearchGate publication ID291354518

P50authorTushar Kanti MaitiQ88055369
P2093author name stringPranita Hanpude
Sushmita Bhattacharya
P2860cites workGain of function of mutant p53 by coaggregation with multiple tumor suppressorsQ57670523
Emerging Anatomy of the BAP1 Tumor Suppressor SystemQ58236865
Protein stability versus function: effects of destabilizing missense mutations onBRCA1DNA repair activityQ64461858
Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2OQ24293775
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBQ24309403
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.Q24323060
Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1Q24329078
BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localizationQ24337105
BAP1 is phosphorylated at serine 592 in S-phase following DNA damageQ24339530
Frequent mutation of BAP1 in metastasizing uveal melanomasQ24601069
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expressionQ24633127
Germline BAP1 mutations predispose to malignant mesotheliomaQ24635326
Thermodynamic stability of wild-type and mutant p53 core domainQ24648879
Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteinsQ28281645
BAP1 protein loss by immunohistochemistry: a potentially useful tool for prognostic prediction in patients with uveal melanomaQ30457154
Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegenerationQ30653185
Further evidence for germline BAP1 mutations predisposing to melanoma and malignant mesotheliomaQ30654878
Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomasQ33581027
The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complexQ33698585
A molecular revolution in uveal melanoma: implications for patient care and targeted therapyQ33717375
Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinomaQ33821055
Disease-causing missense mutations in actin binding domain 1 of dystrophin induce thermodynamic instability and protein aggregationQ34006640
Missense mutations in dystrophin that trigger muscular dystrophy decrease protein stability and lead to cross-beta aggregatesQ34093884
Protein folding in the cytoplasm and the heat shock responseQ34152827
The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesotheliomaQ34190027
BAP1 loss defines a new class of renal cell carcinomaQ34280223
A novel germline mutation in BAP1 predisposes to familial clear-cell renal cell carcinoma.Q34413144
Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.Q34467478
A recurrent mutation in PARK2 is associated with familial lung cancerQ35059365
Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's diseaseQ35084195
Propagation of aggregated p53: Cross-reaction and coaggregation vs. seedingQ35134517
Mechanism of initiation of aggregation of p53 revealed by Φ-value analysisQ35134797
Regulators of homologous recombination repair as novel targets for cancer treatment.Q35200273
Development of cancer-initiating cells and immortalized cells with genomic instabilityQ35205699
α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's diseaseQ35569310
MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.Q36041862
Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer.Q36201740
Evaluating Drosophila p53 as a model system for studying cancer mutationsQ36492803
Germline BAP1 mutations predispose to renal cell carcinomasQ36909238
BAP1 and cancerQ37221089
Tumor suppressor and deubiquitinase BAP1 promotes DNA double-strand break repairQ37474898
Loss of the tumor suppressor BAP1 causes myeloid transformationQ37545704
Tumours associated with BAP1 mutations.Q38070634
The complex function of hsp70 in metastatic cancer.Q38173257
Prion-like aggregation of mutant p53 in cancerQ38207799
Targeting heat shock proteins in metastatic castration-resistant prostate cancerQ38289945
Amyloidogenicity of p53: a hidden link between protein misfolding and cancerQ38360401
Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregationQ38898283
Mutant p53 reprograms TNF signaling in cancer cells through interaction with the tumor suppressor DAB2IP.Q38934179
Germline mutations in BAP1 impair its function in DNA double-strand break repairQ38988548
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functionsQ39610788
Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroidsQ39698063
Induction of Hsp90 protein expression in malignant melanomas and melanoma metastasesQ40580807
Tumorigenic mutations in VHL disrupt folding in vivo by interfering with chaperonin bindingQ40613613
Breast cancer risk and possible mechanisms of radiation-induced genomic instability in the Swedish hemangioma cohort after reanalyzed dosimetryQ41118614
BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genesQ41752870
Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanomaQ41881966
Germline BAP1 mutations predispose also to multiple basal cell carcinomas.Q42463261
Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma.Q43806776
Fibrillar aggregates of the tumor suppressor p53 core domainQ44528743
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)18462
P577publication date2015-12-18
P1433published inScientific ReportsQ2261792
P1476titleCancer associated missense mutations in BAP1 catalytic domain induce amyloidogenic aggregation: A new insight in enzymatic inactivation
P478volume5