From discovery to approval of an advanced therapy medicinal product-containing stem cells, in the EU

scientific article published on 19 April 2016

From discovery to approval of an advanced therapy medicinal product-containing stem cells, in the EU is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.2217/RME-2015-0051
P932PMC publication ID5561870
P698PubMed publication ID27091398

P50authorAlessandro LambiaseQ59666660
Gian M CavalliniQ59670213
Graziella PellegriniQ39817850
P2093author name stringPaolo Rama
Claudio Macaluso
Augusto Pocobelli
Sophie Deng
Roza Esteki
P2860cites workp63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferationQ24652976
Presentation, diagnosis and management of limbal stem cell deficiencyQ26860955
ABCB5 is a limbal stem cell gene required for corneal development and repairQ28244028
The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cellsQ28262541
Cyclin/PCNA is the auxiliary protein of DNA polymerase-deltaQ28282859
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial developmentQ28587664
p63 is a p53 homologue required for limb and epidermal morphogenesisQ28588206
Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cellsQ29614425
Ocular surface epithelia contain ABCG2-dependent side population cells exhibiting features associated with stem cellsQ33213763
Transit-amplifying cells orchestrate stem cell activity and tissue regenerationQ40156869
Bone Marrow Stress Decreases Osteogenic ProgenitorsQ40684057
Successful transplantation of bioengineered tissue replacements in patients with ocular surface diseaseQ41752830
Successful reconstruction of damaged ocular outer surface in humans using limbal and conjuctival stem cell culture methodsQ42456300
Tracing the fate of limbal epithelial progenitor cells in the murine cornea.Q42461276
The control of epidermal stem cells (holoclones) in the treatment of massive full-thickness burns with autologous keratinocytes cultured on fibrin.Q42478449
Association of p63 with proliferative potential in normal and neoplastic human keratinocytesQ42481013
Identification of human corneal epithelial stem cells on the basis of high ABCG2 expression combined with a large N/C ratioQ42518589
An evaluation of cultivated corneal limbal epithelial cells, using cell-suspension cultureQ42523064
Autologous fibrin-cultured limbal stem cells permanently restore the corneal surface of patients with total limbal stem cell deficiencyQ42823761
The microenvironment of coeliac disease: T cell phenotypes and expression of the T2 'T blast' antigen by small bowel lymphocytesQ46799755
Functional regeneration of supraspinal connections in a patient with transected spinal cord following transplantation of bulbar olfactory ensheathing cells with peripheral nerve bridging.Q48477753
Cytologic evidence of corneal diseases with limbal stem cell deficiency.Q52205427
Simple limbal epithelial transplantation (SLET): a novel surgical technique for the treatment of unilateral limbal stem cell deficiency.Q53186068
Immunocytochemical Diagnosis of Limbal Stem Cell Deficiency: Comparative Analysis of Current Corneal and Conjunctival Biomarkers.Q53507618
Comparative study of limbal stem cell deficiency diagnosis methods: detection of MUC5AC mRNA and goblet cells in corneal epithelium.Q54326244
Diversity of cytokeratinsQ58439482
Oligopotent stem cells are distributed throughout the mammalian ocular surfaceQ59054808
Limbal Stem-Cell Therapy and Long-Term Corneal RegenerationQ60289583
Long-term restoration of damaged corneal surfaces with autologous cultivated corneal epitheliumQ60289643
Limbal autograft transplantation for ocular surface disordersQ69657610
Permanent coverage of large burn wounds with autologous cultured human epitheliumQ70370012
Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells(1)Q73055475
Long-term regeneration of human epidermis on third degree burns transplanted with autologous cultured epithelium grown on a fibrin matrixQ73383554
Limbal cell autograft transplantation for severe ocular surface disordersQ77150371
p63: revving up epithelial stem-cell potentialQ80551013
In vivo confocal microscopic evaluation of corneal changes in chronic Stevens-Johnson syndrome and toxic epidermal necrolysisQ83763482
Long-term outcome of cultivated oral mucosal epithelial sheet transplantation in treatment of total limbal stem cell deficiencyQ84100559
Clinical outcomes of xeno-free autologous cultivated limbal epithelial transplantation: a 10-year studyQ84887437
Contemporary in vivo confocal microscopy of the living human cornea using white light and laser scanning techniques: a major review.Q33273764
Evaluation of ocular surface disorders: a new diagnostic tool based on impression cytology and confocal laser scanning microscopyQ33501434
The anti-oxidative role of ABCG2 in corneal epithelial cellsQ33600923
Isoforms of DeltaNp63 and the migration of ocular limbal cells in human corneal regenerationQ33892334
Characterization of limbal stem cell deficiency by in vivo laser scanning confocal microscopy: a microstructural approachQ34096729
Limbal stem cell deficiency: concept, aetiology, clinical presentation, diagnosis and managementQ34104676
Epithelial transplantation for the management of severe ocular surface diseaseQ34211476
Concise review: hurdles in a successful example of limbal stem cell-based regenerative medicine.Q34371318
Three clonal types of keratinocyte with different capacities for multiplicationQ34393745
Preferential biological processes in the human limbus by differential gene profiling.Q34695668
p63 identifies keratinocyte stem cellsQ34707172
The birth of therapy with cultured cellsQ34806793
Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19Q35089351
Wnt/β-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells.Q35220940
Autologous limbal transplantation in patients with unilateral corneal stem cell deficiencyQ35313855
The multifaceted adult epidermal stem cellQ35595944
Characterization of ex vivo cultured limbal, conjunctival, and oral mucosal cells: A comparative study with implications in transplantation medicineQ35908643
Biomechanical strain induces elastin and collagen production in human pluripotent stem cell-derived vascular smooth muscle cellsQ35958572
Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cellsQ36212986
Silk fibroin as a biomaterial substrate for corneal epithelial cell sheet generationQ36223722
Location and clonal analysis of stem cells and their differentiated progeny in the human ocular surface.Q36256645
The development of 'feeder' cells for the preparation of clinical grade hES cell lines: challenges and solutions.Q36475609
Regeneration of squamous epithelia from stem cells of cultured grafts.Q36804602
Identification and functional characterization of two new transcriptional variants of the human p63 geneQ37393495
Frizzled 7 maintains the undifferentiated state of human limbal stem/progenitor cells.Q37649858
13 years of cultured limbal epithelial cell therapy: a review of the outcomes.Q37838845
Review of alternative carrier materials for ocular surface reconstructionQ38176949
The OV-TL 12/30 clone of anti-cytokeratin 7 antibody as a new marker of corneal conjunctivalization in patients with limbal stem cell deficiencyQ38516906
Bioengineering Hematopoietic Stem Cell Niche toward Regenerative MedicineQ38623004
Biological parameters determining the clinical outcome of autologous cultures of limbal stem cellsQ39409846
C/EBPdelta regulates cell cycle and self-renewal of human limbal stem cells.Q39742035
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivativesQ6937225
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectsensory nervous systemQ11101
eukaryoteQ19088
medicinal plantQ188840
tissueQ40397
corneal diseaseQ10526382
tissue engineeringQ1540285
stem cell transplantationQ65592366
biomedical investigative techniqueQ66648976
investigational therapyQ73510198
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)407-420
P577publication date2016-04-19
2016-06-01
P1433published inRegenerative MedicineQ19921466
P1476titleFrom discovery to approval of an advanced therapy medicinal product-containing stem cells, in the EU
P478volume11

Reverse relations

cites work (P2860)
Q94496069A Small-Molecule Wnt Mimic Improves Human Limbal Stem Cell Ex Vivo Expansion
Q55554954Advantages of Graphene Biosensors for Human Stem Cell Therapy Potency Assays.
Q92000194An update on chemical eye burns
Q57179325Approaches for Effective Clinical Application of Stem Cell Transplantation
Q47852082Challenges of running a GMP facility for regenerative medicine in a public hospital.
Q38658337Concise Review: Stem Cells for Corneal Wound Healing
Q87825288[Stem cell-based approaches to diseases of the ocular surface]
Q52711523[The emerging technology of tissue engineering : Focus on stem cell niche].

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