Increasing uncertainty in CNS clinical trials: the role of placebo, nocebo, and Hawthorne effects

scientific article published on 19 April 2016

Increasing uncertainty in CNS clinical trials: the role of placebo, nocebo, and Hawthorne effects is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1474-4422(16)00066-1
P8608Fatcat IDrelease_pnaep3q36vft5icyfpcre5ric4
P698PubMed publication ID27106073

P2093author name stringFabrizio Benedetti
Elisa Carlino
Alessandro Piedimonte
P2860cites workCatechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndromeQ21133920
Lacosamide for neuropathic pain and fibromyalgia in adultsQ24203727
Parkinson's disease gene therapy: success by design meets failure by efficacyQ26851325
Placebo effects: from the neurobiological paradigm to translational implicationsQ26996428
Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorderQ28251587
Potentiation of placebo analgesia by proglumideQ28283820
AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trialQ28307713
Lessons learned from placebo groups in antidepressant trialsQ28478927
Hawthorne effect with transient behavioral and biochemical changes in a randomized controlled sleep extension trial of chronically short-sleeping obese adults: implications for the design and interpretation of clinical studiesQ28542404
Listening to Prozac but hearing placebo: A meta-analysis of antidepressant medicationQ28745052
Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trialQ33628834
Safety and tolerability of putaminal AADC gene therapy for Parkinson diseaseQ33731687
Pharmacoeconomic evaluation in the real world. Effectiveness versus efficacy studiesQ33761452
Socially induced placebo analgesia: a comparison of a pre-recorded versus live face-to-face observationQ33769926
Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: an analysis of the Food and Drug Administration databaseQ33898438
Expectation and dopamine release: mechanism of the placebo effect in Parkinson's diseaseQ34086449
Placebo response in studies of major depression: variable, substantial, and growingQ34122652
Nocebo is the enemy, not placebo. A meta-analysis of reported side effects after placebo treatment in headachesQ34158126
A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's diseaseQ34209755
Overt versus covert treatment for pain, anxiety, and Parkinson's diseaseQ34359487
Effects of perceived treatment on quality of life and medical outcomes in a double-blind placebo surgery trialQ44832150
Development of the Stanford Expectations of Treatment Scale (SETS): a tool for measuring patient outcome expectancy in clinical trialsQ45181057
Hidden administration of drugsQ46714765
Nocebo effects in multiple sclerosis trials: a meta-analysisQ46822234
Illness by suggestion: expectancy, modeling, and gender in the production of psychosomatic symptomsQ47811043
Pain and the contextQ47912833
A double-blind, placebo-controlled study of aripiprazole adjunctive to antidepressant therapy among depressed outpatients with inadequate response to prior antidepressant therapy (ADAPT-A Study).Q48742900
The effect of the sex of a model on nocebo hyperalgesia induced by social observational learning.Q50479720
Placebo analgesia induced by social observational learning.Q50600120
Creating placebo responders and nonresponders in the laboratory: boons and banes.Q50653849
Nocebo hyperalgesia induced by social observational learning.Q50742963
Placebo response in depression: bane of research, boon to therapy.Q55034604
Response expectancy as a determinant of experience and behaviorQ55924357
For Placebo Effects in Medicine, Seeing Is BelievingQ57850432
Placebo Effects in MedicineQ60304535
Clinical trial outcome in neuropathic pain: Relationship to study characteristicsQ60678746
Nonopioid placebo analgesia is mediated by CB1 cannabinoid receptorsQ60688268
Objective changes in motor function during placebo treatment in PDQ64796855
Effectiveness versus efficacy: more than a debate over languageQ73336821
An extension of control group designQ80311034
Mechanisms involved in placebo and nocebo responses and implications for drug trialsQ85047394
Trial design issues and treatment effect modeling in multi‐regional schizophrenia trialsQ85097129
Is acupuncture analgesia an expectancy effect? Preliminary evidence based on participants' perceived assignments in two placebo-controlled trials.Q34388991
Nocebo and placebo modulation of hypobaric hypoxia headache involves the cyclooxygenase-prostaglandins pathwayQ34400035
Placebos and painkillers: is mind as real as matter?Q34431140
FAAH selectively influences placebo effectsQ34461780
The double-blind variable placebo lead-in period: results from two antidepressant clinical trialsQ34474851
Increasing placebo responses over time in U.S. clinical trials of neuropathic painQ34491005
The impact of patient expectations on outcomes in four randomized controlled trials of acupuncture in patients with chronic painQ34606885
Placebo response in Parkinson's disease: comparisons among 11 trials covering medical and surgical interventionsQ34743030
A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety.Q34893258
Are all placebo effects equal? Placebo pills, sham acupuncture, cue conditioning and their associationQ34917757
Seeing facial expressions enhances placebo analgesia.Q35062225
The Problem of the Placebo Response in Clinical Trials for Psychiatric Disorders: Culprits, Possible Remedies, and a Novel Study Design ApproachQ35111772
Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical TrialsQ35832190
Placebo effects on human mu-opioid activity during painQ35846183
Dissociable influences of opiates and expectations on painQ36070260
Placebo-related effects in clinical trials in schizophrenia: what is driving this phenomenon and what can be done to minimize it?Q36119267
Placebo response in clinical trials of depression and its implications for research on chronic neuropathic painQ36356568
Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patientsQ37027502
A primer on effectiveness and efficacy trialsQ37549837
A systematic review of adverse events in placebo groups of anti-migraine clinical trialsQ37603565
Differences in adverse effect reporting in placebo groups in SSRI and tricyclic antidepressant trials: a systematic review and meta-analysisQ37610143
Placebo and the new physiology of the doctor-patient relationshipQ37655894
Systematic review of the Hawthorne effect: new concepts are needed to study research participation effectsQ37671448
Drugs and placebos: what's the difference?: Understanding the molecular basis of the placebo effect could help clinicians to better use it in clinical practiceQ37707506
The placebo effect: From concepts to genes.Q37723087
Nocebo in fibromyalgia: meta-analysis of placebo-controlled clinical trials and implications for practiceQ37942656
Adverse events attributable to nocebo in randomized controlled drug trials in fibromyalgia syndrome and painful diabetic peripheral neuropathy: systematic reviewQ37984188
The placebo response in medicine: minimize, maximize or personalize?Q38085499
Nocebo vs. placebo: the challenges of trial design in analgesia researchQ38351533
Genetics and the placebo effect: the placebomeQ38425277
What is causing the reduced drug-placebo difference in recent schizophrenia clinical trials and what can be done about it?Q40055789
Placebo influences on dyskinesia in Parkinson's diseaseQ40136999
Placebo and opioid analgesia-- imaging a shared neuronal networkQ42162385
Activation of the opioidergic descending pain control system underlies placebo analgesia.Q43285483
A meta-analytic approach to estimating nocebo effects in neuropathic pain trials.Q43662938
The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanilQ44349496
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseQ44571920
P433issue7
P921main subjectplaceboQ269829
noceboQ1332954
P304page(s)736-747
P577publication date2016-04-19
P1433published inLancet NeurologyQ15755067
P1476titleIncreasing uncertainty in CNS clinical trials: the role of placebo, nocebo, and Hawthorne effects
P478volume15

Reverse relations

cites work (P2860)
Q47202221'Caution, this treatment is a placebo. It might work, but it might not': why emerging mechanistic evidence for placebo effects does not legitimise complementary and alternative medicines in sport
Q64084870A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
Q55252484Accurate pain reporting training diminishes the placebo response: Results from a randomised, double-blind, crossover trial.
Q58747426Brain and psychological determinants of placebo pill response in chronic pain patients
Q92850729Can Insights From Placebo and Nocebo Mechanism Studies Help Improve Randomized Controlled Trials?
Q49721453Clinical Pharmacokinetics and Pharmacodynamics of Drugs in the Central Nervous System
Q47555962Clinical relevance of contextual factors as triggers of placebo and nocebo effects in musculoskeletal pain.
Q93061667Effectiveness of a tailored, integrative Internet intervention (deprexis) for depression: Updated meta-analysis
Q55394934Efficacy and Safety of Analgesic Treatment for Depression in People with Advanced Dementia: Randomised, Multicentre, Double-Blind, Placebo-Controlled Trial (DEP.PAIN.DEM).
Q58555579How do placebos work?
Q57556808How placebo characteristics can influence estimates of intervention effects in trials
Q28069705Incorporating Natural Products, Pharmaceutical Drugs, Self-Care and Digital/Mobile Health Technologies into Molecular-Behavioral Combination Therapies for Chronic Diseases
Q90732566Neuroimaging Studies of Antidepressant Placebo Effects: Challenges and Opportunities
Q38736906Nocebo in motor neuron disease: systematic review and meta-analysis of placebo-controlled clinical trials
Q92665801Non-concealed placebo treatment for menopausal hot flushes: Study protocol of a randomized-controlled trial
Q92644323Pain, placebo, and test of treatment efficacy: a narrative review
Q103002620Placebo response mitigation with a participant-focused psychoeducational procedure: a randomized, single-blind, all placebo study in major depressive and psychotic disorders
Q52776632Placebos in clinical trials: unravelling a complex phenomenon - Authors' reply.
Q52776636Placebos in clinical trials: unravelling a complex phenomenon.
Q92634042Practice-Based Research in Complementary Medicine: Could N-of-1 Trials Become the New Gold Standard?
Q38759815Side effects can enhance treatment response through expectancy effects: an experimental analgesic randomized controlled trial
Q46251724Studying placebo effects in model organisms will help us understand them in humans.
Q92764171The Dangerous Side of Placebo Research: Is Hard Science Boosting Pseudoscience?
Q90472112The impact of contextual factors on nursing outcomes and the role of placebo/nocebo effects: a discussion paper
Q91790752The need to investigate nocebo effects in more detail
Q48088458The placebo effect on bradykinesia in Parkinson's disease with and without prior drug conditioning
Q92413870Three randomized studies of dentine hypersensitivity reduction after short-term SnF2 toothpaste use
Q39408152What techniques might be used to harness placebo effects in non-malignant pain? A literature review and survey to develop a taxonomy
Q42110583Why We should Assess Patients' Expectations in Clinical Trials
Q100489476Why we need more research into the placebo response in psychiatry

Search more.