T cells and IL-17 in lupus nephritis.

scientific article published on 21 April 2016

T cells and IL-17 in lupus nephritis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CLIM.2016.04.010
P932PMC publication ID5074925
P698PubMed publication ID27109641

P50authorKunihiro IchinoseQ56987282
P2093author name stringGeorge C Tsokos
Tomohiro Koga
P2860cites workSystemic lupus erythematosus.Q53202066
Short term administration of costimulatory blockade and cyclophosphamide induces remission of systemic lupus erythematosus nephritis in NZB/W F1 mice by a mechanism downstream of renal immune complex depositionQ56903863
Treatment of murine lupus with monoclonal anti-T cell antibodyQ69863949
Elevation of proinflammatory cytokine (IL-18, IL-17, IL-12) and Th2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosusQ73086966
Molecular basis of deficient IL-2 production in T cells from patients with systemic lupus erythematosusQ73587050
Abnormal NF-kappa B activity in T lymphocytes from patients with systemic lupus erythematosus is associated with decreased p65-RelA protein expressionQ78025502
Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosusQ79609793
Measurement of natural (CD4+CD25high) and inducible (CD4+IL-10+) regulatory T cells in patients with systemic lupus erythematosusQ80725358
Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cellsQ80800895
Activated memory B cell subsets correlate with disease activity in systemic lupus erythematosus: delineation by expression of CD27, IgD, and CD95Q81361060
CREMα overexpression decreases IL-2 production, induces a T(H)17 phenotype and accelerates autoimmunityQ83486678
The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosusQ84579960
Successful treatment of subacute lupus erythematosus with ustekinumabQ84772264
Calcium/calmodulin-dependent kinase IV in immune and inflammatory responses: novel routes for an ancient travellerQ24324585
The biological functions of T helper 17 cell effector cytokines in inflammationQ24614431
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5Q24635387
Pouring fuel on the fire: Th17 cells, the environment, and autoimmunityQ26863295
Lupus nephritis: the evolving role of novel therapeuticsQ26998390
A genome-wide association study identifies IL23R as an inflammatory bowel disease geneQ28270603
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)Q28280453
The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanismQ28771751
Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIVQ28972565
Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammationQ29614224
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generationQ29614840
Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupusQ33591655
HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE.Q33717763
Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activityQ33887202
The IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunityQ33961011
IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cellsQ34053939
Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosusQ34078675
Cutting edge: IL-23 receptor deficiency prevents the development of lupus nephritis in C57BL/6-lpr/lpr miceQ34080154
Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in miceQ34090173
The classification of glomerulonephritis in systemic lupus erythematosus revisitedQ34293066
Lupus nephritis: a critical reviewQ34299943
Mechanistic target of rapamycin activation triggers IL-4 production and necrotic death of double-negative T cells in patients with systemic lupus erythematosusQ34361763
Clinical associations of serum interleukin-17 in systemic lupus erythematosusQ34365880
Mechanistic target of rapamycin complex 1 expands Th17 and IL-4+ CD4-CD8- double-negative T cells and contracts regulatory T cells in systemic lupus erythematosusQ34412837
Transcriptional activation of the cAMP-responsive modulator promoter in human T cells is regulated by protein phosphatase 2A-mediated dephosphorylation of SP-1 and reflects disease activity in patients with systemic lupus erythematosus.Q34503070
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6Q34521302
Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosusQ34574768
The two TORCs and Akt.Q34617423
Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity.Q34765324
Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneysQ34892862
IL-17 and IL-23 in lupus nephritis - association to histopathology and response to treatmentQ35078183
KN-93, an inhibitor of calcium/calmodulin-dependent protein kinase IV, promotes generation and function of Foxp3⁺ regulatory T cells in MRL/lpr mice.Q35124586
Targeting lymphocyte signaling pathways as a therapeutic approach to systemic lupus erythematosusQ35172134
Cutting edge: Calcium/Calmodulin-dependent protein kinase type IV is essential for mesangial cell proliferation and lupus nephritis.Q35566402
cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosusQ35604631
T cell signaling abnormalities contribute to aberrant immune cell function and autoimmunityQ35836112
Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanismQ35884233
American College of Rheumatology guidelines for screening, treatment, and management of lupus nephritisQ36221407
Calcium/calmodulin-dependent protein kinase IV suppresses IL-2 production and regulatory T cell activity in lupusQ36252570
Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritisQ36302245
cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus.Q36339914
Rho Kinase Inhibition as a Therapeutic for Progressive Supranuclear Palsy and Corticobasal DegenerationQ36507768
Enhanced rho-associated protein kinase activation in patients with systemic lupus erythematosusQ36901827
Treatment with anti-interleukin 23 antibody ameliorates disease in lupus-prone miceQ36948466
The chemokine network in systemic lupus erythematous nephritisQ36991974
PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cellsQ37143035
Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodelingQ37168446
cAMP-responsive element modulator α (CREMα) trans-represses the transmembrane glycoprotein CD8 and contributes to the generation of CD3+CD4-CD8- T cells in health and diseaseQ37272180
The role of IL-23/IL-17 axis in lupus nephritisQ37397437
Interleukin 2 and systemic lupus erythematosus: beyond the transcriptional regulatory net abnormalitiesQ37408824
cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cellsQ37511786
CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalanceQ37726675
The Th17 immune response in renal inflammationQ37726972
IL-23: A Promising Therapeutic Target for Systemic Lupus ErythematosusQ37777456
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolismQ37792556
IL-17-producing T cells in lupus nephritisQ37838092
IL-17-producing γδ T cells and innate lymphoid cellsQ38040743
Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cellsQ38206864
The role of T cells in systemic lupus erythematosus: an updateQ38232658
Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation.Q40499969
Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activityQ41959555
Calcium/Calmodulin-Dependent Kinase IV Facilitates the Recruitment of Interleukin-17-Producing Cells to Target Organs Through the CCR6/CCL20 Axis in Th17 Cell-Driven Inflammatory Diseases.Q42137258
Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female miceQ43716866
Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosusQ45025165
Gene expression of cytokines (TNF-α, IFN-γ), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosusQ47422803
Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial.Q50906224
Uncoupling of immune complex formation and kidney damage in autoimmune glomerulonephritis.Q52529090
P304page(s)95-99
P577publication date2016-04-21
P1433published inClinical ImmunologyQ15752921
P1476titleT cells and IL-17 in lupus nephritis
P478volume185

Reverse relations

cites work (P2860)
Q55163735Aberrant T Cell Signaling and Subsets in Systemic Lupus Erythematosus.
Q39122679B cell contribution of the CD4+ T cell inflammatory phenotypes in systemic lupus erythematosus
Q90009309B cells control lupus autoimmunity by inhibiting Th17 and promoting Th22 cells
Q98735477Disease Stage-Specific Pathogenicity of CD138 (Syndecan 1)-Expressing T Cells in Systemic Lupus Erythematosus
Q90398897Ets Family Transcription Factor Fli-1 Promotes Leukocyte Recruitment and Production of IL-17A in the MRL/Lpr Mouse Model of Lupus Nephritis
Q64264430FKN Facilitates HK-2 Cell EMT and Tubulointerstitial Lesions via the Wnt/β-Catenin Pathway in a Murine Model of Lupus Nephritis
Q33801351IFN-λ1 with Th17 axis cytokines and IFN-α define different subsets in systemic lupus erythematosus (SLE).
Q87887570IL-17C/IL-17 Receptor E Signaling in CD4+ T Cells Promotes TH17 Cell-Driven Glomerular Inflammation
Q60044009Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients
Q36184303Increased Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis.
Q91594507Machine learning approaches to predict lupus disease activity from gene expression data
Q33620555Pathways leading to an immunological disease: systemic lupus erythematosus
Q42059217Regulation of MiR-146a and TRAF6 in the Diagnose of Lupus Nephritis
Q93122187Splicing factor SRSF1 controls T cell hyperactivity and systemic autoimmunity
Q39175811T cells and autoimmune kidney disease.
Q52724555T cells from induced and spontaneous models of SLE recognize a common T cell epitope on β2-glycoprotein I.
Q38956350T cells in Systemic Lupus Erythematosus
Q91802506Th17 Cells and the IL-23/IL-17 Axis in the Pathogenesis of Periodontitis and Immune-Mediated Inflammatory Diseases
Q64972429The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could Be.
Q47281638The role of CaMK4 in immune responses

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