Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma.

scientific article published on 19 November 2015

Topological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma. is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1037057045
P356DOI10.1038/SREP16830
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/srep16830
P932PMC publication ID4652178
P698PubMed publication ID26582089
P5875ResearchGate publication ID284185543

P50authorCarlos Alberto Moreira-FilhoQ59690993
Hátylas AzevedoQ85489814
P2860cites workHallmarks of Cancer: The Next GenerationQ22252312
The emerging paradigm of network medicine in the study of human diseaseQ27026041
Emergence of Scaling in Random NetworksQ27037290
Human cancer protein-protein interaction network: a structural perspectiveQ28472174
Lethality and centrality in protein networksQ29547267
Error and attack tolerance of complex networksQ29547268
Predictive genomics: a cancer hallmark network framework for predicting tumor clinical phenotypes using genome sequencing dataQ30804500
Why do hubs tend to be essential in protein networks?Q33245657
MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survivalQ33280922
Identifying disease-specific genes based on their topological significance in protein networksQ33421110
PrognoScan: a new database for meta-analysis of the prognostic value of genesQ33434943
GeneMANIA Cytoscape plugin: fast gene function predictions on the desktopQ33711706
clusterMaker: a multi-algorithm clustering plugin for CytoscapeQ34070756
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistanceQ34307356
Attack robustness and centrality of complex networksQ34657945
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis toolQ34668270
Temozolomide-modulated glioma proteome: role of interleukin-1 receptor-associated kinase-4 (IRAK4) in chemosensitivityQ34675920
Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cellsQ34988108
Analysis of candidate genes has proposed the role of y chromosome in human prostate cancerQ35015903
Protective properties of radio-chemoresistant glioblastoma stem cell clones are associated with metabolic adaptation to reduced glucose dependence.Q35048997
Computing topological parameters of biological networks.Q51900389
Downregulation of PAK5 inhibits glioma cell migration and invasion potentially through the PAK5-Egr1-MMP2 signaling pathway.Q53089129
Modular organization of cancer signaling networks is associated with patient survivabilityQ62728415
Attack vulnerability of complex networksQ74282136
Mechanisms of drug combinations: interaction and network perspectivesQ83265745
GenCLiP 2.0: a web server for functional clustering of genes and construction of molecular networks based on free termsQ87750481
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancerQ35134003
Chemotherapeutic effect of tamoxifen on temozolomide-resistant gliomasQ35533102
Molecular signaling network complexity is correlated with cancer patient survivabilityQ36061531
A map of human cancer signalingQ36327214
Identifying critical transitions and their leading biomolecular networks in complex diseasesQ36455314
Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cellsQ36681945
A modular analysis framework for blood genomics studies: application to systemic lupus erythematosusQ37308037
Topological properties of protein interaction networks from a structural perspectiveQ37330462
A systems biology view of cancerQ37434945
Molecular mechanisms of temozolomide resistance in glioblastoma multiformeQ38010801
Interleukins in glioblastoma pathophysiology: implications for therapy.Q38051761
Network pharmacology strategies toward multi-target anticancer therapies: from computational models to experimental design principlesQ38093187
Therapeutic targeting of EGFR-activated metabolic pathways in glioblastomaQ38111449
Glioblastoma and other malignant gliomas: a clinical review.Q38160159
Deciphering molecular determinants of chemotherapy in gastrointestinal malignancy using systems biology approachesQ38209079
Quantitative proteomic analysis and functional studies reveal that nucleophosmin is involved in cell death in glioblastoma cell line transfected with siRNA.Q38496343
TAZ promotes temozolomide resistance by upregulating MCL-1 in human glioma cellsQ38867558
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-κB-inducing kinase (NIK) and noncanonical NF-κB signalingQ38916371
Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas.Q38925318
MiR-622 suppresses proliferation, invasion and migration by directly targeting activating transcription factor 2 in glioma cellsQ38953118
Overexpressed miRNA-137 inhibits human glioma cells growth by targeting Rac1.Q39158791
The microarray gene profiling analysis of glioblastoma cancer cells reveals genes affected by FAK inhibitor Y15 and combination of Y15 and temozolomideQ39198605
Rectifying cancer drug discovery through network pharmacologyQ39226874
Distinct molecular mechanisms of acquired resistance to temozolomide in glioblastoma cellsQ39352627
STAT3 inhibition overcomes temozolomide resistance in glioblastoma by downregulating MGMT expressionQ39359062
Inhibition of Aurora kinases enhances chemosensitivity to temozolomide and causes radiosensitization in glioblastoma cells.Q39429784
Immunohistochemical actinin-4 expression in infiltrating gliomas: association with WHO grade and differentiationQ39450108
Temozolomide-induced modification of the CXC chemokine network in experimental gliomasQ39576881
Gene expression profiling predicts response to temozolomide in malignant gliomasQ39709566
Acquired resistance to temozolomide in glioma cell lines: molecular mechanisms and potential translational applications.Q39720269
Rational design of cancer-drug combinationsQ40106730
Genetic alterations associated with acquired temozolomide resistance in SNB-19, a human glioma cell lineQ40229852
Analyzing biological network parameters with CentiScaPeQ41961222
The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomasQ47605452
MiR-136 targets E2F1 to reverse cisplatin chemosensitivity in glioma cells.Q48595565
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesCytoscapeQ3699942
P407language of work or nameEnglishQ1860
P921main subjectchemotherapyQ974135
P304page(s)16830
P577publication date2015-11-19
P1433published inScientific ReportsQ2261792
P1476titleTopological robustness analysis of protein interaction networks reveals key targets for overcoming chemotherapy resistance in glioma
P478volume5

Reverse relations

cites work (P2860)
Q38909947Construction of a Comprehensive Protein-Protein Interaction Map for Vitiligo Disease to Identify Key Regulatory Elements: A Systemic Approach
Q36473639Functional divergence and convergence between the transcript network and gene network in lung adenocarcinoma
Q49195059How the evolution of multicellularity set the stage for cancer.
Q54948646Identification of modules of hepatic encephalopathy based on protein-protein network and gene expression data.
Q95322476Metabolomics and Multi-Omics Integration: A Survey of Computational Methods and Resources
Q93005381Mining Featured Biomarkers Linked with Epithelial Ovarian CancerBased on Bioinformatics
Q58769130Minipuberty and Sexual Dimorphism in the Infant Human Thymus
Q92132838Modeling Basins of Attraction for Breast Cancer Using Hopfield Networks
Q39704507NIK regulates MT1-MMP activity and promotes glioma cell invasion independently of the canonical NF-κB pathway
Q29091067Network biology concepts in complex disease comorbidities
Q34523885PTIR: Predicted Tomato Interactome Resource
Q53180121Regulatory feedback loops bridge the human gene regulatory network and regulate carcinogenesis.
Q97561863Small-world networks of prognostic genes associated with lung adenocarcinoma development

Search more.