A collective route to metastasis: Seeding by tumor cell clusters

scientific article published on April 2016

A collective route to metastasis: Seeding by tumor cell clusters is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.AAF6546
P698PubMed publication ID27124449

P2093author name stringAndrew J Ewald
Kevin J Cheung
P2860cites workMetastatic colonization by circulating tumour cellsQ28076164
Epithelial-Mesenchymal Plasticity: A Central Regulator of Cancer ProgressionQ28081012
Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistanceQ28269714
Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal compositionQ29615853
Collective cell migration in morphogenesis, regeneration and cancerQ29616634
Collective invasion in breast cancer requires a conserved basal epithelial programQ30573307
Mechanical feedback through E-cadherin promotes direction sensing during collective cell migrationQ30585627
AACR centennial series: the biology of cancer metastasis: historical perspectiveQ33683443
Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasisQ34111187
The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cellsQ35079440
The evolutionary history of lethal metastatic prostate cancerQ35548366
Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors.Q36071451
Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cellsQ36288896
Pancreatic Cancer Metastases Harbor Evidence of PolyclonalityQ36311734
Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clustersQ36607592
Tumorigenesis: it takes a villageQ38544200
Clinical Significance and Molecular Characteristics of Circulating Tumor Cells and Circulating Tumor Microemboli in Patients With Small-Cell Lung CancerQ58282332
P433issue6282
P407language of work or nameEnglishQ1860
P1104number of pages3
P304page(s)167-169
P577publication date2016-04-01
P1433published inScienceQ192864
P1476titleA collective route to metastasis: Seeding by tumor cell clusters
P478volume352

Reverse relations

cites work (P2860)
Q33803754A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors
Q46280012A conduit to metastasis: circulating tumor cell biology
Q90455031A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling
Q96171887A mouse model for peritoneal metastases of colorectal origin recapitulates patient heterogeneity
Q92165752A possible role for epigenetic feedback regulation in the dynamics of the epithelial-mesenchymal transition (EMT)
Q57035036Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro
Q37592228Aneuploidy of chromosome 8 in circulating tumor cells correlates with prognosis in patients with advanced gastric cancer
Q92802250Between-tumor and within-tumor heterogeneity in invasive potential
Q99584366Biomechanics of Collective Cell Migration in Cancer Progression: Experimental and Computational Methods
Q90573584Bring along your friends: Homotypic and heterotypic circulating tumor cell clustering to accelerate metastasis
Q39052331CTC clusters in cancer progression and metastasis
Q58097045Cancer from the perspective of stem cells and misappropriated tissue regeneration mechanisms
Q33629970Cancer metastasis: enactment of the script for human reproductive drama
Q92035791Cancer stem-like cells with hybrid epithelial/mesenchymal phenotype leading the collective invasion
Q90193154Cell Heterogeneity and Phenotypic Plasticity in Metastasis Formation: The Case of Colon Cancer
Q52353297Cell motility in cancer invasion and metastasis: insights from simple model organisms.
Q57073625Cell-cell adhesion: linking Wnt/β-catenin signaling with partial EMT and stemness traits in tumorigenesis
Q47154025Characterization of epithelial-mesenchymal transition intermediate/hybrid phenotypes associated to resistance to EGFR inhibitors in non-small cell lung cancer cell lines
Q91992051Circulating Hybrid Cells Join the Fray of Circulating Cellular Biomarkers
Q41430303Circulating Tumor Cells: Moving Biological Insights into Detection.
Q52619257Circulating Tumor Cells: Strategies for Capture, Analyses, and Propagation.
Q51732792Coexisting genomic aberrations associated with lymph node metastasis in breast cancer.
Q99732079Collective Cancer Cell Invasion in Contact with Fibroblasts via Integrin-α5β1/Fibronectin Interaction in Collagen Matrix
Q64283645Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors
Q52966702Collective cell migration of thyroid carcinoma cells: a beneficial ability to override unfavourable substrates.
Q52592413Collective gradient sensing and chemotaxis: Modeling and recent developments.
Q38934429Collective migration and cell jamming in asthma, cancer and development
Q55411157Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.
Q41548888Comprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells.
Q90708419Computational Modeling of Collective Cell Migration: Mechanical and Biochemical Aspects
Q41550715Connecting individual to collective cell migration
Q60048013Contribution of epithelial-mesenchymal transitions to organogenesis and cancer metastasis
Q36267896Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma
Q60921922Detection and application of circulating tumor cell and circulating tumor DNA in the non-small cell lung cancer
Q39213292Development and dynamics of cell polarity at a glance
Q50138593Dissemination from a Solid Tumor: Examining the Multiple Parallel Pathways
Q90312259Dynamics of Phenotypic Heterogeneity Associated with EMT and Stemness during Cancer Progression
Q92286802E-Cadherin and Syndecan-1 Expression in Patients With Advanced Non-small Cell Lung Cancer Treated With Chemoradiotherapy
Q88742268E-cadherin in contact inhibition and cancer
Q89151859EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration
Q33869775EMT and MET: necessary or permissive for metastasis?
Q92528442EMT and Stemness-Key Players in Pancreatic Cancer Stem Cells
Q47736873EMT in cancer
Q57796306EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma
Q37534373Emergent structures and dynamics of cell colonies by contact inhibition of locomotion.
Q64935328Emerging Roles of the Endoplasmic Reticulum Associated Unfolded Protein Response in Cancer Cell Migration and Invasion.
Q92686706Energetic regulation of coordinated leader-follower dynamics during collective invasion of breast cancer cells
Q47244877Engineering and physical sciences in oncology: challenges and opportunities
Q33869760Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?
Q58739441Exploring the molecular mechanism associated with breast cancer bone metastasis using bioinformatic analysis and microarray genetic interaction network
Q92156808Fibronectin in Cancer: Friend or Foe
Q58708380From individual to collective 3D cancer dissemination: roles of collagen concentration and TGF-β
Q38703766Homogeneous pancreatic cancer spheroids mimic growth pattern of circulating tumor cell clusters and macrometastases: displaying heterogeneity and crater-like structure on inner layer
Q90114463Hybrid Epithelial/Mesenchymal State in Cancer Metastasis: Clinical Significance and Regulatory Mechanisms
Q89900060Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells
Q30851875Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion.
Q92733449Improving Single-Cell Encapsulation Efficiency and Reliability through Neutral Buoyancy of Suspension
Q37423979In epithelial cancers, aberrant COL17A1 promoter methylation predicts its misexpression and increased invasion.
Q60105719Inferring parsimonious migration histories for metastatic cancers
Q33767606Inflammatory breast cancer: a model for investigating cluster-based dissemination.
Q64093794Interactions in the (Pre)metastatic Niche Support Metastasis Formation
Q91869765Interconnected feedback loops among ESRP1, HAS2, and CD44 regulate epithelial-mesenchymal plasticity in cancer
Q64086629Intraflagellar transport 20 promotes collective cancer cell invasion by regulating polarized organization of Golgi-associated microtubules
Q58709810Intravital microscopy of collective invasion plasticity in breast cancer
Q92962964Investigating circulating tumor cells and distant metastases in patient-derived orthotopic xenograft models of triple-negative breast cancer
Q91589958Karyotyping of circulating tumor cells for predicting chemotherapeutic sensitivity and efficacy in patients with esophageal cancer
Q89967149LRRC4 Suppresses E-Cadherin-Dependent Collective Cell Invasion and Metastasis in Epithelial Ovarian Cancer
Q64254546Long Noncoding RNA and Epithelial Mesenchymal Transition in Cancer
Q47370965Lymph Node Metastases in Colon Cancer are Polyclonal
Q88697944Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression
Q92154823Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies
Q88012838Metastasis inside-out: dissemination of cancer cell clusters with inverted polarity
Q64108079MicroRNA in Lung Cancer Metastasis
Q90482809Molecular principles of metastasis: a hallmark of cancer revisited
Q92074829NRF2 activates a partial epithelial-mesenchymal transition and is maximally present in a hybrid epithelial/mesenchymal phenotype
Q93252546New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer
Q47162554Numb prevents a complete epithelial-mesenchymal transition by modulating Notch signalling.
Q92190049PEP06 polypeptide 30 is a novel cluster-dissociating agent inhibiting α v integrin/FAK/Src signaling in oral squamous cell carcinoma cells
Q59755807PSPC1 mediates TGF-β1 autocrine signalling and Smad2/3 target switching to promote EMT, stemness and metastasis
Q57112752Pancreatic and bile duct cancer circulating tumor cells (CTC) form immune-resistant multi-cell type clusters in the portal venous circulation
Q49494629Physical models of collective cell motility: from cell to tissue
Q47401259Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer
Q55398181Platelet Metabolism and Other Targeted Drugs; Potential Impact on Immunotherapy.
Q38431117Poor Prognosis Indicated by Venous Circulating Tumor Cell Clusters in Early Stage Lung Cancers
Q42362521Preclinical Modeling and Therapeutic Avenues for Cancer Metastasis to the Central Nervous System
Q41273487Proceedings of the 3rd Annual Albert Institute for Bladder Cancer Research Symposium.
Q94532928Protein phosphatase 1 activity controls a balance between collective and single cell modes of migration
Q89534554Quantification of multicellular colonization in tumor metastasis using exome-sequencing data
Q92310025Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues
Q38700311Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3.
Q64941550Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics.
Q33732986Revisiting the hallmarks of cancer
Q91874572Single-cell EMT-related transcriptional analysis revealed intra-cluster heterogeneity of tumor cell clusters in epithelial ovarian cancer ascites
Q90633154Subpopulation targeting of pyruvate dehydrogenase and GLUT1 decouples metabolic heterogeneity during collective cancer cell invasion
Q47673602Survival Outcomes in Cancer Patients Predicted by a Partial EMT Gene Expression Scoring Metric
Q92984320Systems Biology of Cancer Metastasis
Q90587477Testing the gene expression classification of the EMT spectrum
Q60914167The Adaptive Complexity of Cancer
Q91823882The Emerging Link between Centrosome Aberrations and Metastasis
Q38998765The Mechanics of Single Cell and Collective Migration of Tumor Cells
Q92932351The RNA-binding protein AKAP8 suppresses tumor metastasis by antagonizing EMT-associated alternative splicing
Q60914623The Role of MicroRNAs in the Metastatic Process of High-Risk HPV-Induced Cancers
Q92500902The endoderm: a divergent cell lineage with many commonalities
Q90008712The functional activity of E-cadherin controls tumor cell metastasis at multiple steps
Q58705856The implications of signaling lipids in cancer metastasis
Q39122602The importance of regulatory ubiquitination in cancer and metastasis
Q102388836The lingering mysteries of metastatic recurrence in breast cancer
Q92002391The natural compound neobractatin inhibits tumor metastasis by upregulating the RNA-binding-protein MBNL2
Q91659773The role of clonal communication and heterogeneity in breast cancer
Q98613082The special issue on cancer and evolution: Lessons learned
Q47709614The α6β4 integrin promotes resistance to ferroptosis
Q99636345Tumor resident stromal cells promote breast cancer invasion through regulation of the basal phenotype
Q41580419Tumour heterogeneity promotes collective invasion and cancer metastatic dissemination
Q39092645Tuning Collective Cell Migration by Cell-Cell Junction Regulation.
Q97543675Whole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1
Q92884310Wnt/PCP Signaling Contribution to Carcinoma Collective Cell Migration and Metastasis
Q57117510[When is surgical resection of the primary tumor indicated in metastatic prostate cancer and what is the scientific rationale?]

Search more.