Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis

scientific article published on 20 April 2017

Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2017.04.012
P932PMC publication ID5516936
P698PubMed publication ID28434938

P2093author name stringXin Chen
Kairong Cui
Keji Zhao
Gang Wei
Lijuan Feng
Suk Ho Eun
Qiang Gan
Luis Cedeno-Rosario
P2860cites workControl of germline stem cell division frequency--a novel, developmentally regulated role for epidermal growth factor signalingQ21134586
Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like propertiesQ24307391
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27Q24672052
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste proteinQ24682617
The regulated elimination of transit-amplifying cells preserves tissue homeostasis during protein starvation in Drosophila testisQ27342959
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomainsQ27641772
High-resolution profiling of histone methylations in the human genomeQ27860906
Role of histone H3 lysine 27 methylation in Polycomb-group silencingQ28131795
Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cueQ28212990
Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signalingQ28213000
Antagonistic roles of Rac and Rho in organizing the germ cell microenvironmentQ28236468
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Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewalQ28285729
Germline self-renewal requires cyst stem cells and stat regulates niche adhesion in Drosophila testesQ28287607
The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formationQ28292501
A misexpression screen reveals effects of bag-of-marbles and TGF beta class signaling on the Drosophila male germ-line stem cell lineageQ28768694
Histone methyltransferase activity of a Drosophila Polycomb group repressor complexQ29615394
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sitesQ29615395
Analysis of genetic mosaics in developing and adult Drosophila tissuesQ29617838
Centrosome misorientation reduces stem cell division during ageingQ30488902
Asymmetric division of cyst stem cells in Drosophila testis is ensured by anaphase spindle repositioningQ30498121
Somatic control over the germline stem cell lineage during Drosophila spermatogenesis.Q47070091
Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivoQ47070334
Genetic control of cell proliferation and differentiation in Drosophila spermatogenesisQ47071501
Assembly of ring canals in the male germ line from structural components of the contractile ring.Q47071871
PRC2 controls Drosophila oocyte cell fate by repressing cell cycle genes.Q47815003
Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progenyQ50743424
Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome.Q52100403
Regulation of zygotic gene expression in Drosophila primordial germ cells.Q52189834
The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis.Q52549418
bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis.Q52559441
A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell.Q52603134
Differentiating germ cells can revert into functional stem cells in Drosophila melanogaster ovaries.Q52646597
Dynamics of the male germline stem cell population during aging of Drosophila melanogaster.Q53615479
Stem Cells and Cancer: Two Faces of EveQ59243883
Accumulation of a differentiation regulator specifies transit amplifying division number in an adult stem cell lineageQ33564155
A non-cell autonomous role of E(z) to prevent germ cells from turning on a somatic cell markerQ33692440
Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testisQ33909578
Somatic support cells restrict germline stem cell self-renewal and promote differentiation.Q33922721
Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogasterQ33956903
Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tipQ34210638
Repression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell developmentQ34235662
Functional hierarchy and reversibility within the murine spermatogenic stem cell compartmentQ34308801
Polycomb complexes and silencing mechanisms.Q34320981
Somatic control of germline sexual development is mediated by the JAK/STAT pathwayQ34498977
Sequential changes at differentiation gene promoters as they become active in a stem cell lineageQ35001684
The stem cell niche: lessons from the Drosophila testisQ35057655
Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cellsQ35592848
Niche signaling promotes stem cell survival in the Drosophila testis via the JAK-STAT target DIAP1Q35748670
Efficiency of spermatogonial dedifferentiation during agingQ35839916
An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation.Q36167267
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failureQ36241895
Transcriptional regulation during Drosophila spermatogenesisQ36312074
Somatic cell lineage is required for differentiation and not maintenance of germline stem cells in Drosophila testes.Q36389537
MicroRNAs downregulate Bag of marbles to ensure proper terminal differentiation in the Drosophila male germlineQ36444115
Epigenetic regulator Lid maintains germline stem cells through regulating JAK-STAT signaling pathway activityQ36506699
Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in miceQ36677747
Bam and Bgcn antagonize Nanos-dependent germ-line stem cell maintenanceQ37224248
Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testisQ37361116
Regulation of self-renewal and differentiation in adult stem cell lineages: lessons from the Drosophila male germ lineQ37426157
Polycomb group proteins set the stage for early lineage commitmentQ37784086
Transcriptional regulation by Polycomb group proteinsQ38149730
The large Maf factor Traffic Jam controls gonad morphogenesis in DrosophilaQ38348751
The Drosophila Enhancer of zeste gene encodes a chromosomal protein: examination of wild-type and mutant protein distributionQ38559594
Targeting Polycomb systems to regulate gene expression: modifications to a complex storyQ38595464
Mouse differentiating spermatogonia can generate germinal stem cells in vivoQ39903133
Hierarchical recruitment of polycomb group silencing complexesQ40549661
Asymmetric inheritance of mother versus daughter centrosome in stem cell divisionQ41956545
bag-of-marbles: a Drosophila gene required to initiate both male and female gametogenesisQ42102438
Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testisQ43602218
Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpartQ46375956
Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation.Q47070063
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
P304page(s)2030-2041
P577publication date2017-04-21
P1433published inJournal of Molecular BiologyQ925779
P1476titlePolycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis
P478volume429

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cites work (P2860)
Q55421968A Targeted RNAi Screen Reveals Drosophila Female-Sterile Genes That Control the Size of Germline Stem Cell Niche During Development.
Q98286423Differentiating Drosophila female germ cells initiate Polycomb silencing by regulating PRC2-interacting proteins
Q90248604Regulation of Drosophila germline stem cells
Q89982639Single-cyst transcriptome analysis of Drosophila male germline stem cell lineage

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