Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target

scientific article published on 19 October 2015

Phenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3109/10715762.2015.1108520
P698PubMed publication ID26480821

P2093author name stringSutapa Mukherjee
Jaydip Biswas
Madhumita Roy
Ruma Sarkar
P2860cites workReactive oxygen species: role in the development of cancer and various chronic conditionsQ24548312
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Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cellsQ28533351
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Dietary phenethylisothiocyanate attenuates bowel inflammation in miceQ33566354
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Hemin, an iron-binding porphyrin, inhibits HIF-1α induction through its binding with heat shock protein 90.Q38476087
Deferoxamine promotes MDA-MB-231 cell migration and invasion through increased ROS-dependent HIF-1α accumulationQ39004163
Targeting heat shock proteins by phenethyl isothiocyanate results in cell-cycle arrest and apoptosis of human breast cancer cellsQ39175428
Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner.Q39208900
E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cellsQ39402009
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.Q39698231
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Cul3 overexpression depletes Nrf2 in breast cancer and is associated with sensitivity to carcinogens, to oxidative stress, and to chemotherapyQ39819761
Inhibition of hypoxia inducible factor by phenethyl isothiocyanate.Q39859462
Hypoxia-inducible factor (HIF)-1 alpha directly enhances the transcriptional activity of stem cell factor (SCF) in response to hypoxia and epidermal growth factor (EGF).Q40002656
Reactive oxygen species stabilize hypoxia-inducible factor-1 alpha protein and stimulate transcriptional activity via AMP-activated protein kinase in DU145 human prostate cancer cellsQ40015395
Hypoxia stimulates breast carcinoma cell invasion through MT1-MMP and MMP-2 activationQ40337557
In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions: involvement of PI-3K/Akt and MEK1/ERK pathways.Q40457587
Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization.Q40523929
Apoptosis Induction by Polygonum minus is related to antioxidant capacity, alterations in expression of apoptotic-related genes, and S-phase cell cycle arrest in HepG2 cell lineQ40557869
Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interactionQ40920382
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathwayQ44019897
Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.Q46042294
Hypoxic induction of HIF-1alpha and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinasesQ46149613
Chemoprevention of acrylamide toxicity by antioxidative agents in rats--effective suppression of testicular toxicity by phenylethyl isothiocyanateQ46466757
The time-dependent effect of gluconasturtiin and phenethyl isothiocyanate on metabolic and antioxidative parameters in ratsQ46885760
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.Q51256046
Curcumin augments the efficacy of antitumor drugs used in leukemia by modulation of heat shock proteins via HDAC6.Q53014973
Antioxidant Determinations by the Use of a Stable Free RadicalQ59065485
P433issue1
P921main subjectneoplastic invasivenessQ112498967
metastatic potentialQ122615215
P304page(s)84-100
P577publication date2015-10-19
P1433published inFree Radical ResearchQ5500025
P1476titlePhenethyl isothiocyanate, by virtue of its antioxidant activity, inhibits invasiveness and metastatic potential of breast cancer cells: HIF-1α as a putative target
P478volume50

Reverse relations

cites work (P2860)
Q40459695Antioxidant and anti-inflammatory effects of Nasturtium officinale involved in attenuation of gentamicin-induced nephrotoxicity.
Q55411962BAG3 Protein Is Involved in Endothelial Cell Response to Phenethyl Isothiocyanate.
Q39429454Dietary Natural Products for Prevention and Treatment of Breast Cancer.
Q52331716Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy.
Q48347918Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells.
Q52669816Isothiocyanates: cholinesterase inhibiting, antioxidant, and anti-inflammatory activity.

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