Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo

scientific article published on 19 July 2015

Nitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/JCP.25093
P698PubMed publication ID26189652

P50authorDeclan J McKennaQ89065399
Jenny WorthingtonQ117274233
Stephanie R. McKeownQ124041559
P2093author name stringHeather Nesbitt
Niall M Byrne
Gillian Browne
Katie M O'Donovan
P2860cites workDysregulated pH: a perfect storm for cancer progression.Q45255109
Apoptosis signal-regulating kinase 1-mediated signaling pathway regulates nitric oxide-induced activator protein-1 activation in human bronchial epithelial cellsQ51683319
Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cellsQ28237966
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesionsQ30435146
Normalization of the Vasculature for Treatment of Cancer and Other DiseasesQ30471456
Guidelines for the welfare and use of animals in cancer researchQ33903753
Nitric oxide: NO apoptosis or turning it ON?Q34214972
Nitric oxide and mechanisms of redox signalling: matrix and matrix-metabolizing enzymes as prime nitric oxide targetsQ34430700
Runx2-Smad signaling impacts the progression of tumor-induced bone diseaseQ34898865
Runx2 Protein Stabilizes Hypoxia-inducible Factor-1α through Competition with von Hippel-Lindau Protein (pVHL) and Stimulates Angiogenesis in Growth Plate Hypertrophic ChondrocytesQ35922634
Targeting Runx2 expression in hypertrophic chondrocytes impairs endochondral ossification during early skeletal developmentQ35985042
Critical role of the extracellular signal-regulated kinase-MAPK pathway in osteoblast differentiation and skeletal developmentQ36117930
A role for Runx2 in normal mammary gland and breast cancer bone metastasisQ36211777
Cytoprotective Signaling Associated with Nitric Oxide Upregulation in Tumor Cells Subjected to Photodynamic Therapy-like Oxidative StressQ36674615
Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cellsQ37000350
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancerQ37170747
Ectopic runx2 expression in mammary epithelial cells disrupts formation of normal acini structure: implications for breast cancer progressionQ37343805
Pro-survival and pro-growth effects of stress-induced nitric oxide in a prostate cancer photodynamic therapy modelQ37417193
The yin and yang of nitric oxide in cancer progression.Q38077081
Nitric oxide-p38 MAPK signaling stabilizes mRNA through AU-rich element-dependent and -independent mechanismsQ38294258
ARED 2.0: an update of AU-rich element mRNA database.Q38430539
Parathyroid hormone-related protein protects renal tubuloepithelial cells from apoptosis by activating transcription factor Runx2.Q39201922
Increased expression of activated endothelial nitric oxide synthase contributes to antiandrogen resistance in prostate cancer cells by suppressing androgen receptor transactivation.Q39275054
Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response.Q39292683
Runx2-mediated bcl-2 gene expression contributes to nitric oxide protection against hydrogen peroxide-induced osteoblast apoptosisQ39800854
Inducible NO synthase confers chemoresistance in head and neck cancer by modulating survivinQ39897646
Hypoxia selects for androgen independent LNCaP cells with a more malignant geno- and phenotypeQ39977133
Chemosensitization of cancer in vitro and in vivo by nitric oxide signalingQ40150534
Nitric oxide-mediated inhibition of androgen receptor activity: possible implications for prostate cancer progressionQ40230325
Nitric oxide attenuates resistance to doxorubicin in three-dimensional aggregates of human breast carcinoma cellsQ40343161
Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2.Q40515610
Nitric oxide increases IL-8 gene transcription and mRNA stability to enhance IL-8 gene expression in lung epithelial cellsQ40550831
Bicalutamide-induced hypoxia potentiates RUNX2-mediated Bcl-2 expression resulting in apoptosis resistanceQ41314252
Osteogenic differentiation of human mesenchymal bone marrow cells in silk scaffolds is regulated by nitric oxideQ41339493
CRE DNA binding proteins bind to the AP-1 target sequence and suppress AP-1 transcriptional activity in mouse keratinocytesQ42470001
Fibroblast growth factor 2 induction of the osteocalcin gene requires MAPK activity and phosphorylation of the osteoblast transcription factor, Cbfa1/Runx2.Q44058493
P433issue2
P304page(s)473-482
P577publication date2015-07-19
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleNitric Oxide Up-Regulates RUNX2 in LNCaP Prostate Tumours: Implications for Tumour Growth In Vitro and In Vivo
P478volume231

Reverse relations

cites work (P2860)
Q64118105Differentially Expressed Genes and Molecular Pathways in an Autochthonous Mouse Prostate Cancer Model
Q38733024Distinct Osteomimetic Response of Androgen-Dependent and Independent Human Prostate Cancer Cells to Mechanical Action of Fluid Flow: Prometastatic Implications.
Q38704618Metabolic Modification in Gastrointestinal Cancer Stem Cells: Characteristics and Therapeutic Approaches
Q38829378MiR-30a regulates the proliferation, migration, and invasion of human osteosarcoma by targeting Runx2.
Q47399023Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.
Q33850244ZEB2 promotes tumor metastasis and correlates with poor prognosis of human colorectal cancer

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