Structure and mechanism of assembly line polyketide synthases

scientific article published on 4 June 2016

Structure and mechanism of assembly line polyketide synthases is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.SBI.2016.05.009
P932PMC publication ID5136517
P698PubMed publication ID27266330

P50authorChaitan KhoslaQ5068124
Yu-Chen LiuQ43280967
P2093author name stringDavid E Cane
Thomas Robbins
P2860cites workPHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: Versatility from a unique substrate channelQ27636992
Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthasesQ27639797
The structure of docking domains in modular polyketide synthasesQ27641953
A tylosin ketoreductase reveals how chirality is determined in polyketidesQ27647542
Structural and Mechanistic Analysis of Protein Interactions in Module 3 of the 6-Deoxyerythronolide B SynthaseQ27647550
Solution structure and proposed domain-domain recognition interface of an acyl carrier protein domain from a modular polyketide synthaseQ27648476
The crystal structure of a mammalian fatty acid synthaseQ27651988
Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide HydrolaseQ27663333
Structural and functional analysis of A-type ketoreductases from the amphotericin modular polyketide synthaseQ27663985
Structural and functional analysis of C2-type ketoreductases from modular polyketide synthasesQ27667844
Structure and Mechanism of the trans -Acting Acyltransferase from the Disorazole SynthaseQ27670570
The Missing Linker: A Dimerization Motif Located within Polyketide Synthase ModulesQ27676819
Divergence of multimodular polyketide synthases revealed by a didomain structureQ27679312
Mycocerosic acid synthase exemplifies the architecture of reducing polyketide synthasesQ27704254
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary informationQ29615720
Computational identification and analysis of orphan assembly-line polyketide synthasesQ33640382
Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthasesQ33792791
Polyketide and nonribosomal peptide antibiotics: modularity and versatilityQ33976771
Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthaseQ34438159
Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthaseQ34824345
The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.Q35131209
ClusPro: a fully automated algorithm for protein-protein dockingQ35554797
Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthasesQ35792961
Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongationQ35837046
A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide SynthasesQ36517218
Structure-based analysis of the molecular interactions between acyltransferase and acyl carrier protein in vicenistatin biosynthesis.Q36607621
Structure and mechanism of the 6-deoxyerythronolide B synthaseQ36747462
Isoprenoid-like alkylations in polyketide biosynthesisQ37280642
In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthaseQ37382344
The structures of type I polyketide synthasesQ38031740
The Utilization of Binding Energy in Coupled Vectorial ProcessesQ40122880
Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthasesQ40647813
Structural rearrangements of a polyketide synthase module during its catalytic cycleQ41456081
Structure of a modular polyketide synthaseQ41608053
Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthaseQ42433911
Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraeaQ42611970
Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases.Q44552141
Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthaseQ45131842
The structure of a ketoreductase determines the organization of the beta-carbon processing enzymes of modular polyketide synthases.Q45952293
Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthaseQ46114155
Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modulesQ46203484
Rational design and assembly of synthetic trimodular polyketide synthases.Q54446263
Dissecting and exploiting intermodular communication in polyketide synthasesQ77330305
P407language of work or nameEnglishQ1860
P304page(s)10-18
P577publication date2016-06-04
P1433published inCurrent Opinion in Structural BiologyQ15758416
P1476titleStructure and mechanism of assembly line polyketide synthases
P478volume41

Reverse relations

cites work (P2860)
Q90741130A Photoactivatable Small-Molecule Probe for the In Vivo Capture of Polyketide Intermediates
Q98282975A bimodular PKS platform that expands the biological design space
Q59191311A standardized workflow for submitting data to the Minimum Information about a Biosynthetic Gene cluster (MIBiG) repository: prospects for research-based educational experiences
Q64119430Acquisition and Loss of Secondary Metabolites Shaped the Evolutionary Path of Three Emerging Phytopathogens of Wheat
Q57822331Activation of microbial secondary metabolic pathways: Avenues and challenges
Q42291965Active Multienzyme Assemblies for Long-Chain Olefinic Hydrocarbon Biosynthesis
Q64897732Acyltransferases as Tools for Polyketide Synthase Engineering.
Q55224657Catalysis of transthiolacylation in the active centers of dihydrolipoamide acyltransacetylase components of 2-oxo acid dehydrogenase complexes.
Q58606934Conjugative transposons and their cargo genes vary across natural populations of Rickettsia buchneri infecting the tick Ixodes scapularis
Q47694075Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates
Q90380911Diversification of polyketide structures via synthase engineering
Q50997208Engineering fatty acid synthases for directed polyketide production.
Q91987138Evolution and Diversity of Assembly-Line Polyketide Synthases
Q50900096Evolution inspired engineering of antibiotic biosynthesis enzymes.
Q48720680Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement
Q91708366Gating mechanism of elongating β-ketoacyl-ACP synthases
Q60312685Genetically encodable bioluminescent system from fungi
Q64263635Modular type I polyketide synthase acyl carrier protein domains share a common N-terminally extended fold
Q36035795Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases
Q41366960Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase
Q97425379Site directed mutagenesis as a precision tool to enable synthetic biology with engineered modular polyketide synthases
Q39217986Spatial organization of multi-enzyme biocatalytic cascades.
Q39427118Strategies in megasynthase engineering - fatty acid synthases (FAS) as model proteins
Q88676053Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module
Q48500475Synthetic biology of polyketide synthases.
Q46361736The Conformational Flexibility of the Acyltransferase from the Disorazole Polyketide Synthase Is Revealed by an X-ray Free-Electron Laser Using a Room-Temperature Sample Delivery Method for Serial Crystallography.
Q38761039Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects
Q118163086Transcriptional heterologous expression of two type III PKS from the lichen Cladonia uncialis
Q92557934Translation of Diverse Aramid- and 1,3-Dicarbonyl-peptides by Wild Type Ribosomes in Vitro
Q30101114X-ray Scattering Studies of Protein Structural Dynamics.

Search more.