The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia.

scientific article published on 6 July 2015

The oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1001993512
P356DOI10.1038/ONC.2015.261
P932PMC publication ID4833872
P698PubMed publication ID26148230
P5875ResearchGate publication ID279807257

P50authorJoost H A MartensQ75201047
P2093author name stringH G Stunnenberg
A M Sotoca
A Mandoli
K H M Prange
L N Nguyen
B Reijnders
P2860cites workMultiplex peptide stable isotope dimethyl labeling for quantitative proteomics.Q51758332
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.Q52537887
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice.Q53240659
Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation.Q53408223
Myeloid differentiation antigen and cytokine receptor expression on acute myelocytic leukaemia cells with t(16;21)(p11;q22): frequent expression of CD56 and interleukin-2 receptor alpha chain.Q53437272
Rapid induction of CD38 antigen on myeloid leukemia cells by all trans-retinoic acidQ72095241
Hematopoietic growth factor expression and ATRA sensitivity in acute promyelocytic blast cellsQ72454788
High FUS/TLS expression in acute myeloid leukaemia samplesQ73486050
FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cellsQ84095651
FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosisQ36922849
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemiaQ37226744
Genome-wide functions of PML-RARα in acute promyelocytic leukaemiaQ37829905
FUS expression alters the differentiation response to all-trans retinoic acid in NB4 and NB4R2 cellsQ38298325
Chromatin accessibility, p300, and histone acetylation define PML-RARα and AML1-ETO binding sites in acute myeloid leukemiaQ38322292
Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators.Q39649034
Targeting AML1/ETO-histone deacetylase repressor complex: a novel mechanism for valproic acid-mediated gene expression and cellular differentiation in AML1/ETO-positive acute myeloid leukemia cellsQ40153779
Genomic and proteomic analysis of the myeloid differentiation programQ40790537
A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibitedQ41132547
Retinoic acid-induced expression of CD38 antigen in myeloid cells is mediated through retinoic acid receptor-alphaQ41479286
The ERGonomics of hematopoietic stem cell self-renewalQ41834451
Oncogenic fusion proteins expressed in immature hematopoietic cells fail to recapitulate the transcriptional changes observed in human AML.Q41895366
Context-selective death of acute myeloid leukemia cells triggered by the novel hybrid retinoid-HDAC inhibitor MC2392.Q42774706
Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemiaQ43499854
Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16;21)(p11;q22) and identification of a novel transcriptQ43533951
Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cellsQ44830496
ERG is a megakaryocytic oncogene.Q47677556
Genome-wide analysis of transcriptional regulators in human HSPCs reveals a densely interconnected network of coding and noncoding genes.Q47708383
Model-based analysis of ChIP-Seq (MACS)Q21183902
Identification of novel functional TBP-binding sites and general factor repertoiresQ24295026
Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcomaQ24309359
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progressionQ24313269
TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteinsQ24554236
Fast and accurate short read alignment with Burrows-Wheeler transformQ24653853
Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cellsQ24669651
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.Q27824849
The Sequence Alignment/Map format and SAMtoolsQ27860966
TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t(16;21) chromosomal translocation in human myeloid leukemia functions as a transcriptional activation domainQ28241486
TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttlingQ28246694
A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERGQ28252253
TLS (translocated-in-liposarcoma) is a high-affinity interactor for steroid, thyroid hormone, and retinoid receptorsQ28259754
The transcription factor Spi-1/PU.1 interacts with the potential splicing factor TLSQ28262912
Role of the histone deacetylase complex in acute promyelocytic leukaemiaQ28263534
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cellsQ28281239
ERG transcriptional networks in primary acute leukemia cells implicate a role for ERG in deregulated kinase signalingQ28484833
TLS (Translocated-in-Liposarcoma) Is a High-Affinity Interactor for Steroid, Thyroid Hormone, and Retinoid ReceptorsQ29040351
Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemiaQ29616211
The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblastsQ33884178
Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLSQ33889532
Genome-wide analysis of ETS-family DNA-binding in vitro and in vivoQ34000149
The ETS-domain transcription factor familyQ34066415
PML-RARalpha/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia.Q34099047
Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancerQ34612941
ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemiaQ36395611
PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.Q36802972
Establishment of a novel human acute myeloblastic leukemia cell line (YNH-1) with t(16;21), t(1;16) and 12q13 translocationsQ36853021
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue15
P407language of work or nameEnglishQ1860
P921main subjecttretinoinQ29417
P304page(s)1965-1976
P577publication date2015-07-06
P1433published inOncogeneQ1568657
P1476titleThe oncofusion protein FUS-ERG targets key hematopoietic regulators and modulates the all-trans retinoic acid signaling pathway in t(16;21) acute myeloid leukemia
P478volume35

Reverse relations

cites work (P2860)
Q39058012AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis
Q47117116Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS-ERG fusion gene
Q38807143Developmental Control of NRAMP1 (SLC11A1) Expression in Professional Phagocytes
Q37565198Effective molecular targeting of CDK4/6 and IGF-1R in a rare FUS-ERG fusion CDKN2A-deletion doxorubicin-resistant Ewing's sarcoma patient-derived orthotopic xenograft (PDOX) nude-mouse model.
Q35944651Genome Wide Mapping of NR4A Binding Reveals Cooperativity with ETS Factors to Promote Epigenetic Activation of Distal Enhancers in Acute Myeloid Leukemia Cells
Q39004166MLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia
Q91586332Salvage therapy with azacitidine for pediatric acute myeloid leukemia with t(16;21)(p11;q22)/FUS-ERG and early relapse after allogeneic blood stem cell transplantation: A case report
Q96683851Targeting the ERG oncogene with splice-switching oligonucleotides as a novel therapeutic strategy in prostate cancer
Q90911442The incidence, genetic characteristics, and prognosis of leukemia with concurrent pathogenic fusion genes: a series of 25 cases from a large cohort of leukemia patients
Q91012693The role of the retinoids in schizophrenia: genomic and clinical perspectives
Q92337654Transcriptional networks in acute myeloid leukemia

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