CD4(+) T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells-novel implications of CD4(+) T cells in pancreatic cancer development

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CD4(+) T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells-novel implications of CD4(+) T cells in pancreatic cancer development is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/2162402X.2014.1000083
P8608Fatcat IDrelease_z2ypco25graijelefjb24s6734
P932PMC publication ID4485733
P698PubMed publication ID26137395

P50authorBence SiposQ40927701
Christoph RöckenQ42465274
P2093author name stringDaniela Wesch
Sandra Freitag-Wolf
Susanne Sebens
Hendrik Ungefroren
Heiner Schäfer
Lennart Lenk
Evelin Grage-Griebenow
Ole Helm
Artur Gorys
Geeske Genrich
Lisa Goebel
P2860cites workClinical roles of increased populations of Foxp3+CD4+ T cells in peripheral blood from advanced pancreatic cancer patientsQ79323463
M2-polarized tumor-associated macrophage infiltration of regional lymph nodes is associated with nodal lymphangiogenesis and occult nodal involvement in pN0 pancreatic cancerQ84378919
Significance of M2-polarized tumor-associated macrophage in pancreatic cancerQ84573386
Elevated L1CAM expression in precursor lesions and primary and metastastic tissues of pancreatic ductal adenocarcinomaQ84974299
Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cellsQ24647546
Epithelial-mesenchymal transitions in tumour progressionQ27860487
Cancer statistics, 2013Q27860762
Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and MetastasisQ29396371
EMT and dissemination precede pancreatic tumor formationQ29615854
Immunosuppressive networks in the tumour environment and their therapeutic relevanceQ29619244
Pancreatic cancer alters human CD4+ T lymphocyte function: a piece in the immune evasion puzzleQ33351879
Comparative characterization of stroma cells and ductal epithelium in chronic pancreatitis and pancreatic ductal adenocarcinomaQ33567742
Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumorsQ34138282
Tumor-associated macrophages exhibit pro- and anti-inflammatory properties by which they impact on pancreatic tumorigenesisQ34399827
Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assaysQ34456201
Epithelial-mesenchymal transition (EMT) induced by TNF-α requires AKT/GSK-3β-mediated stabilization of snail in colorectal cancerQ34595133
Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinomaQ35753107
Immortal human pancreatic duct epithelial cell lines with near normal genotype and phenotypeQ35829569
Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesionsQ35887807
Epithelial-mesenchymal transition induced by TNF-α requires NF-κB-mediated transcriptional upregulation of Twist1Q35952706
Pancreatic cancer: basic and clinical aspectsQ36123805
Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancerQ36663615
Pancreatic cancer microenvironmentQ36834237
Immune infiltrates as predictive markers of survival in pancreatic cancer patientsQ38129379
Tumor necrosis factor-α modulates epithelial mesenchymal transition mediators ZEB2 and S100A4 to promote cholangiocarcinoma progressionQ38990922
L1CAM promotes enrichment of immunosuppressive T cells in human pancreatic cancer correlating with malignant progressionQ39003009
Myofibroblast-induced tumorigenicity of pancreatic ductal epithelial cells is L1CAM dependentQ39441186
Positive expression of L1-CAM is associated with perineural invasion and poor outcome in pancreatic ductal adenocarcinomaQ39738407
Up-regulation of L1CAM in pancreatic duct cells is transforming growth factor beta1- and slug-dependent: role in malignant transformation of pancreatic cancerQ39852540
Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasisQ40006251
Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cellsQ40211697
NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2.Q40252191
Location, location, location: macrophage positioning within tumors determines pro- or antitumor activityQ41815433
Immune cells in pancreatic cancer: Joining the dark sideQ42128007
The fatal alliance of cancer and T cells: How pancreatic tumor cells gather immunosuppressive T cellsQ42130225
CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in miceQ42277523
Macrophage activation increases the invasive properties of hepatoma cells by destabilization of the adherens junction.Q51209998
Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions.Q51803685
P433issue4
P921main subjectpancreatic cancerQ212961
P304page(s)e1000083
P577publication date2015-01-22
P1433published inOncoImmunologyQ18026500
P1476titleCD4(+) T cells potently induce epithelial-mesenchymal-transition in premalignant and malignant pancreatic ductal epithelial cells-novel implications of CD4(+) T cells in pancreatic cancer development
P478volume4

Reverse relations

cites work (P2860)
Q42261466Acceleration of pancreatic tumorigenesis under immunosuppressive microenvironment induced by Reg3g overexpression
Q52540247Epithelial-mesenchymal transition and inflammation at the site of the primary tumor.
Q93252546New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer
Q35726483The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells
Q92083224The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System

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