Ras signaling through RASSF proteins

scientific article

Ras signaling through RASSF proteins is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.SEMCDB.2016.06.007
P932PMC publication ID5034565
P698PubMed publication ID27288568

P2093author name stringHoward Donninger
Geoffrey J Clark
M Lee Schmidt
Thibaut Barnoud
Jessica Mezzanotte
P2860cites workPML regulates p53 acetylation and premature senescence induced by oncogenic RasQ22254666
MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domainsQ24290468
The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1Q24292345
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)Q24293710
Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and AktQ24296477
The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1Q24297392
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth controlQ24299106
YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt responseQ24299975
RASSF2 is a novel K-Ras-specific effector and potential tumor suppressorQ24301371
The tumor suppressor RASSF1A and MAP-1 link death receptor signaling to Bax conformational change and cell deathQ24305092
Newly identified stress-responsive protein kinases, Krs-1 and Krs-2Q24308319
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch IIQ24309371
Identification of Nore1 as a potential Ras effectorQ24314874
The tumor suppressor RASSF1A prevents dephosphorylation of the mammalian STE20-like kinases MST1 and MST2.Q24322848
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signallingQ24323370
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complexQ24323508
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4aQ24324559
Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activityQ24336042
Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by RasQ24338128
RASSF2 associates with and stabilizes the proapoptotic kinase MST2Q24338394
Protein phosphatase 1alpha is a Ras-activated Bad phosphatase that regulates interleukin-2 deprivation-induced apoptosisQ24594034
The Hippo Signaling Pathway in Development and CancerQ24603986
Wnt/beta-catenin signaling: components, mechanisms, and diseasesQ24630938
RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor proteinQ24648062
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationQ24669694
RASSF tumor suppressor gene family: biological functions and regulationQ26866080
PP1 and PP2A phosphatases--cooperating partners in modulating retinoblastoma protein activationQ26991427
The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injuryQ27305276
The retinoblastoma protein and cell cycle controlQ27860722
Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosisQ28139203
The pro-apoptotic Ras effector Nore1 may serve as a Ras-regulated tumor suppressor in the lungQ28188823
The t(1;3) breakpoint-spanning genes LSAMP and NORE1 are involved in clear cell renal cell carcinomasQ28190533
Identification of a novel Ras-regulated proapoptotic pathwayQ28203664
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinaseQ28205257
Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2Q28210189
Protein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactionsQ28211695
RASSF3 and NORE1: identification and cloning of two human homologues of the putative tumor suppressor gene RASSF1Q28215344
Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5Q28238668
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growthQ28243336
RAS oncogenes: weaving a tumorigenic webQ28250360
RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamicsQ28267593
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancerQ28283044
Ablation of Rassf2 induces bone defects and subsequent haematopoietic anomalies in miceQ28509403
RASSF6 is a novel member of the RASSF family of tumor suppressorsQ28509722
Menin determines K-RAS proliferative outputs in endocrine cellsQ28589291
Correlation between hypermethylation of the RASSF2A promoter and K-ras/BRAF mutations in microsatellite-stable colorectal cancersQ34570590
Silencing of RASSF3 by DNA hypermethylation is associated with tumorigenesis in somatotroph adenomasQ34650707
Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent mannerQ34676703
The RASSF1A tumor suppressor regulates XPA-mediated DNA repairQ34968548
Promoter methylation status of Ras-association domain family members in pheochromocytomaQ35099523
Frequent promoter hypermethylation of RASSF1A and CASP8 in neuroblastomaQ35126668
Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesisQ35132940
Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling deviceQ35158033
Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesionsQ35186531
The dark side of Ras: regulation of apoptosisQ35603375
Clinical utility of RASSF1A methylation in human malignanciesQ35909621
Intrinsic tumour suppressionQ35953133
RASSF1A and the rs2073498 Cancer Associated SNPQ35971247
Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases.Q36050995
Role of the Ras-association domain family 1 tumor suppressor gene in human cancersQ36113844
Modulator of apoptosis 1 (MOAP-1) is a tumor suppressor protein linked to the RASSF1A protein.Q36115786
Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1Q28592139
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolismQ29547302
Live or let die: the cell's response to p53Q29547663
ras oncogenes in human cancer: a reviewQ29547769
Ras oncogenes: split personalitiesQ29615405
Caught up in a Wnt storm: Wnt signaling in cancerQ29617494
A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kinQ29618006
NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2.Q30370843
Ras history: The saga continuesQ30404024
A RASSF1A polymorphism restricts p53/p73 activation and associates with poor survival and accelerated age of onset of soft tissue sarcomaQ30413809
A comprehensive survey of Ras mutations in cancerQ30416821
Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3.Q30884723
The Ras-association domain family (RASSF) members and their role in human tumourigenesisQ31121564
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recoveryQ33292088
High mutability of the tumor suppressor genes RASSF1 and RBSP3 (CTDSPL) in cancerQ33455585
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancerQ33591673
Epigenetic inactivation of the NORE1gene correlates with malignant progression of colorectal tumorsQ33726187
RASSF6 promotes p21(Cip1/Waf1)-dependent cell cycle arrest and apoptosis through activation of the JNK/SAPK pathway in clear cell renal cell carcinomaQ33728900
Cross-regulation between oncogenic BRAF(V600E) kinase and the MST1 pathway in papillary thyroid carcinomaQ33797782
Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xLQ33819193
The Ras effector RASSF2 controls the PAR-4 tumor suppressorQ33877015
Understanding Ras: 'it ain't over 'til it's over'.Q33877218
The importance of being K-RasQ34034093
Ras and Rho GTPases: a family reunionQ34073399
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.Q34108288
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanismQ34140558
Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer.Q34168295
Tumor Suppressor Ras Association Domain Family 5 (RASSF5/NORE1) Mediates Death Receptor Ligand-induced ApoptosisQ34251431
Oncogenic ras and p53 cooperate to induce cellular senescenceQ34279104
The MDM2-p53 interaction.Q34288001
Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1.Q34379673
The Ras effector RASSF2 is a novel tumor-suppressor gene in human colorectal cancerQ34433428
Ras regulates SCF(β-TrCP) protein activity and specificity via its effector protein NORE1A.Q34467504
Cell cycle restriction is more important than apoptosis induction for RASSF1A protein tumor suppressionQ34467580
The RASSF1A tumor suppressor activates Bax via MOAP-1.Q34475337
Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis.Q34498682
The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemiasQ39830585
RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt.Q39882775
RASSF1A, BLU, NORE1A, PTEN and MGMT expression and promoter methylation in gliomas and glioma cell lines and evidence of deregulated expression of de novo DNMTs.Q39963026
Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.Q40009864
Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathwaysQ40157708
Ras association domain family 1C protein stimulates human lung cancer cell proliferationQ40246812
Involvement of the RASSF1A tumor suppressor gene in controlling cell migrationQ40377886
RASSF4/AD037 is a potential ras effector/tumor suppressor of the RASSF family.Q40485735
Aberrant methylation of RASSF4/AD037 in nasopharyngeal carcinoma.Q40514524
Inactivation of RASSF1C during in vivo tumor growth identifies it as a tumor suppressor geneQ40543079
A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stabilityQ40543835
NORE1A Regulates MDM2 Via β-TrCP.Q40681916
Protein interaction switches coordinate Raf-1 and MST2/Hippo signallingQ42152409
Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to ChemotherapyQ42184843
The Drosophila RASSF homolog antagonizes the hippo pathwayQ42236170
Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in miceQ42416763
NORE1A tumor suppressor candidate modulates p21CIP1 via p53.Q42799756
Tumour biology: senescence in premalignant tumoursQ42802962
A negative feedback signaling network underlies oncogene-induced senescenceQ43116108
Protein phosphatase 1alpha-mediated stimulation of apoptosis is associated with dephosphorylation of the retinoblastoma proteinQ43761465
Control of microtubule stability by the RASSF1A tumor suppressorQ44645799
Multigene methylation analysis of Wilms' tumour and adult renal cell carcinomaQ47445963
ATR kinase as master regulator of nucleotide excision repair during S phase of the cell cycleQ47806230
Nore1 inhibits tumor cell growth independent of Ras or the MST1/2 kinasesQ47984176
RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer.Q50752468
PPP1CA contributes to the senescence program induced by oncogenic Ras.Q53325013
Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers.Q53338659
Ubiquitous activation of Ras and Jak/Stat pathways in human HCC.Q53347351
Ras-driven proliferation and apoptosis signaling during rat liver carcinogenesis is under genetic control.Q53460647
Relationship of Ras association domain family 1 methylation and K-ras mutation in primary non-small cell lung cancerQ53649603
Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.Q54541000
Nuclear transport of Ras-associated tumor suppressor proteins: different transport receptor binding specificities for arginine-rich nuclear targeting signals.Q55043344
RASSF1C, an Isoform of the Tumor Suppressor RASSF1A, Promotes the Accumulation of β-Catenin by Interacting with βTrCPQ61824843
NORE1A, a homologue of RASSF1A tumour suppressor gene is inactivated in human cancersQ72992695
MST1-JNK promotes apoptosis via caspase-dependent and independent pathwaysQ74152681
High frequency somatic mutations in RASSF1A in nasopharyngeal carcinomaQ81050017
Gene methylation in pleural mesothelioma: correlations with clinico-pathological features and patient's follow-upQ81405822
Recognizing and defining true Ras binding domains I: biochemical analysisQ81643533
PTEN, RASSF1 and DAPK site-specific hypermethylation and outcome in surgically treated stage I and II nonsmall cell lung cancer patientsQ84609988
Decreased expression and aberrant methylation of RASSF5A correlates with malignant progression of gastric cardia adenocarcinomaQ86046632
RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB PathwayQ87063270
RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cellsQ36216004
The RASSF gene family members RASSF5, RASSF6 and RASSF7 show frequent DNA methylation in neuroblastomaQ36383883
Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancerQ36394050
Ras Regulates Rb via NORE1A.Q36548478
Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformationQ36556010
Critical Tyrosine Residues Regulate the Enzymatic and Biological Activity of Raf-1 KinaseQ36826443
Senescence in tumours: evidence from mice and humansQ36903843
The RASSF1A tumor suppressorQ36945316
DNA damage signalling guards against activated oncogenes and tumour progressionQ37027188
Rassf family of tumor suppressor polypeptides.Q37353443
Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppressionQ37410567
The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formationQ37660499
Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.Q37761824
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of TumorigenesisQ37903701
DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosisQ37977244
Controversial aspects of oncogene-induced senescenceQ38055308
The Hippo pathway: regulators and regulationsQ38083640
Inside and out: the activities of senescence in cancer.Q38230319
Rassf3 is responsible in part for resistance to mammary tumor development in neu transgenic mice.Q38357380
Forging a signature of in vivo senescenceQ38536371
NORE1A induction by membrane-bound CD40L (mCD40L) contributes to CD40L-induced cell death and G1 growth arrest in p21-mediated mechanismQ38785550
RASSF1A Directly Antagonizes RhoA Activity through the Assembly of a Smurf1-Mediated Destruction Complex to Suppress TumorigenesisQ38798230
Alternate RASSF1 Transcripts Control SRC Activity, E-Cadherin Contacts, and YAP-Mediated InvasionQ38821010
RASSF4 is downregulated in nonsmall cell lung cancer and inhibits cancer cell proliferation and invasionQ38822769
RASSF5A, a candidate tumor suppressor, is epigenetically inactivated in esophageal squamous cell carcinomaQ38920937
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.Q38956821
RASSF1A inactivation unleashes a tumor suppressor/oncogene cascade with context-dependent consequences on cell cycle progressionQ39004151
The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein.Q39100434
Small proline-rich protein-1B is overexpressed in human oral squamous cell cancer stem-like cells and is related to their growth through activation of MAP kinase signalQ39108870
Epstein-Barr virus latent membrane protein 1 increases genomic instability through Egr-1-mediated up-regulation of activation-induced cytidine deaminase in B-cell lymphomaQ39202093
The RASSF3 candidate tumor suppressor induces apoptosis and G1-S cell-cycle arrest via p53.Q39347028
Proteomics Analysis Reveals Novel RASSF2 Interaction PartnersQ39583823
Functional importance of RASSF1A microtubule localization and polymorphismsQ39669245
ATM regulates a RASSF1A-dependent DNA damage responseQ39766802
Frequent promoter hypermethylation of tumor-related genes in head and neck squamous cell carcinomaQ39779862
Hippo pathway-dependent and -independent roles of RASSF6.Q39792600
P304page(s)86-95
P577publication date2016-06-08
P1433published inSeminars in Cell & Developmental BiologyQ14330411
P1476titleRas signaling through RASSF proteins
P478volume58

Reverse relations

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