Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease

scientific article published on 28 March 2017

Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.NEUROPHARM.2017.03.030
P932PMC publication ID6511375
P698PubMed publication ID28363773

P50authorThor D SteinQ34445851
Jacob M. HookerQ52280455
P2093author name stringBenjamin Wolozin
Haihao Zhu
Neil Kowall
Xiehua Xue
Wei Qiao Qiu
Qiushan Tao
Hana Na
Erming Wang
Max Wallack
P2860cites workInsulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradationQ22008492
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Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene productQ28138337
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregationQ28245143
Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunctionQ29547778
Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathwaysQ30175699
Reduced IGF-1 signaling delays age-associated proteotoxicity in miceQ30497845
Islet amyloid polypeptide in the islets of Langerhans: friend or foe?Q33976606
On the Relation of Chronic Interstitial Pancreatitis to the Islands of Langerhans and to Diabetes MelutusQ34019932
Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease.Q34167833
Amyloid fibrils composed of hexameric peptides attenuate neuroinflammationQ34336783
Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system.Q34349457
Amylin deposition in the brain: A second amyloid in Alzheimer disease?Q34352928
Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic aβ peptide aggregatesQ34672360
Actions of β-amyloid protein on human neurons are expressed through the amylin receptorQ34760866
Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical culturesQ34779219
Cdk5: One of the links between senile plaques and neurofibrillary tangles?Q35116571
GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunitiesQ36153247
Central nervous system and other effectsQ36402880
G protein-coupled receptor signaling complexity in neuronal tissue: implications for novel therapeuticsQ36742422
Positive association between plasma amylin and cognition in a homebound elderly populationQ36807576
Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.Q37297656
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer's diseaseQ37331433
Modulating receptor function through RAMPs: can they represent drug targets in themselves?Q37371266
Complement and microglia mediate early synapse loss in Alzheimer mouse models.Q37391481
The role of G protein-coupled receptors in the pathology of Alzheimer's diseaseQ37830311
Solanezumab for the treatment of mild-to-moderate Alzheimer's diseaseQ37979840
The interaction of amylin with other hormones in the control of eatingQ38031993
Amylin and the regulation of appetite and adiposity: recent advances in receptor signaling, neurobiology and pharmacologyQ38062765
Janus faces of amyloid proteins in neuroinflammationQ38202911
Amylin and its analogs: a friend or foe for the treatment of Alzheimer's disease?Q38239648
Differential expression of membrane sialoglycoproteins in exudate and resident mouse peritoneal macrophagesQ38343959
Amylin: Pharmacology, Physiology, and Clinical PotentialQ38526856
Amylin-mediated control of glycemia, energy balance, and cognitionQ38753342
Amylin Treatment Reduces Neuroinflammation and Ameliorates Abnormal Patterns of Gene Expression in the Cerebral Cortex of an Alzheimer's Disease Mouse Model.Q39136356
Multiple target of hAmylin on rat primary hippocampal neuronsQ39288319
Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activityQ40975717
A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineageQ41183035
A phase 3 trial of semagacestat for treatment of Alzheimer's diseaseQ42710153
Enhanced amylin-mediated body weight loss in estradiol-deficient diet-induced obese ratsQ42852579
G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuseQ43070751
An insulin-degrading enzyme inhibitor decreases amylin degradation, increases amylin-induced cytotoxicity, and increases amyloid formation in insulinoma cell culturesQ44564031
Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunizationQ44833066
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET studyQ46373170
Differential permeability of the blood-brain barrier to two pancreatic peptides: insulin and amylinQ47849481
Plasma amylin immunoreactivity and insulin resistance in insulin resistant relatives of patients with non-insulin-dependent diabetes mellitusQ47983953
Comparison of the effects of chronic central administration and chronic peripheral administration of islet amyloid polypeptide on food intake and meal pattern in the rat.Q48114139
Beta amyloid-induced depression of hippocampal long-term potentiation is mediated through the amylin receptorQ48273018
Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.Q48404445
Effect of active Aβ immunotherapy on neurons in human Alzheimer's diseaseQ48445250
Neuroprotective effects of the amylin analogue pramlintide on Alzheimer's disease pathogenesis and cognition.Q48869814
Quantitative neurohistological features of frontotemporal degenerationQ49140415
Microglial alterations in human Alzheimer's disease following Aβ42 immunization.Q53282250
Effects of sequential proline substitutions on amyloid formation by human amylin20-29.Q54128400
Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5Q60603655
Amylin: localization, effects on cerebral arteries and on local cerebral blood flow in the cat.Q64965686
Amylin-induced relaxation of the perfused mesenteric arterial bed: meditation by calcitonin gene-related peptide receptorsQ71013459
Permeability of the blood-brain barrier to amylinQ71520909
Pharmacokinetics and pharmacodynamics of AC137 (25,28,29 tripro-amylin, human) after intravenous bolus and infusion doses in patients with insulin-dependent diabetesQ71809920
Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicityQ72621646
Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brainQ73843429
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Safety of pramlintide added to mealtime insulin in patients with type 1 or type 2 diabetes: a large observational studyQ84343828
Emerging therapeutics for Alzheimer's diseaseQ87039918
P4510describes a project that usesImageJQ1659584
P921main subjectAlzheimer's diseaseQ11081
P304page(s)170-181
P577publication date2017-03-28
P1433published inNeuropharmacologyQ15332439
P1476titleAmylin receptor ligands reduce the pathological cascade of Alzheimer's disease
P478volume119

Reverse relations

cites work (P2860)
Q48099438Activation of amylin receptors attenuates alcohol-mediated behaviours in rodents
Q90070082Amylin Signaling in Diabetes and Alzheimer's Disease: Therapy or Pathology?
Q39320824Amylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease
Q89947927Amylin and pramlintide modulate γ-secretase level and APP processing in lipid rafts
Q47322028Amylin in Alzheimer's disease: Pathological peptide or potential treatment?
Q92747901Association of Plasma Amylin Concentration With Alzheimer Disease and Brain Structure in Older Adults
Q89955963Characterization of the effects of calcitonin gene-related peptide receptor antagonist for Alzheimer's disease
Q91883726Effects of Amylin Against Amyloid-β-Induced Tauopathy and Synapse Loss in Primary Neurons
Q92804142Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer's disease
Q57069272Neuroprotective Effects of Amylin Analogues on Alzheimer's Disease Pathogenesis and Cognition
Q51246561Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer's Disease.
Q42376572Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
Q50181740Structural Modulation of Human Amylin Protofilaments by Naturally-Occurring Mutations
Q59792740Sub-Toxic Human Amylin Fragment Concentrations Promote the Survival and Proliferation of SH-SY5Y Cells via the Release of VEGF and HspB5 from Endothelial RBE4 Cells

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