Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance

scientific article published on June 2015

Exploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.3902
P932PMC publication ID4558170
P698PubMed publication ID26036632
P5875ResearchGate publication ID277783432

P50authorAntonio MasQ45634126
Francisco Jose CimasQ56953554
Félix A. JalónQ60632546
P2093author name stringAimé Vazquez
Jesús García-Cano
Leticia Serrano-Oviedo
Ricardo Sánchez-Prieto
Gorbatchev Ambroise
María José Ruiz-Hidalgo
Isabel Sanchez Perez
Maria Carmen Carrión
Marta Ortega-Muelas
Raquel Pascual-Serra
Sebastià Sabater
P2860cites workGuidelines for the use and interpretation of assays for monitoring autophagyQ21996341
Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLCQ28478252
BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular componentsQ28486502
Upregulation of autophagy-related gene-5 (ATG-5) is associated with chemoresistance in human gastric cancerQ28543901
Requirement for p53 and p21 to sustain G2 arrest after DNA damageQ29547667
Cisplatin: mode of cytotoxic action and molecular basis of resistanceQ29615385
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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitorQ29616727
3-Methyladenine: specific inhibitor of autophagic/lysosomal protein degradation in isolated rat hepatocytesQ29617843
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Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagyQ30513775
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Synergistic killing of lung cancer cells by cisplatin and radiation via autophagy and apoptosisQ33727550
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Concomitant inhibition of AKT and autophagy is required for efficient cisplatin-induced apoptosis of metastatic skin carcinoma.Q33829753
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Abrogation of the p38 MAPK α signaling pathway does not promote radioresistance but its activity is required for 5-Fluorouracil-associated radiosensitivity.Q39195786
Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formationQ39353049
P38MAPK is a major determinant of the balance between apoptosis and autophagy triggered by 5-fluorouracil: implication in resistanceQ39490275
Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosisQ39520993
Acquired cisplatin resistance in human lung adenocarcinoma cells is associated with enhanced autophagyQ39734588
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Blocked autophagy sensitizes resistant carcinoma cells to radiation therapyQ40006232
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3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagyQ42520512
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TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma.Q43202682
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Role of the p38 MAPK pathway in cisplatin-based therapyQ44488190
Monofunctional platinum complexes showing potent cytotoxicity against human liver carcinoma cell line BEL-7402.Q44523317
Reversal of cisplatin resistance with a BH3 mimetic, (-)-gossypol, in head and neck cancer cells: role of wild-type p53 and Bcl-xL.Q46601653
Satraplatin (JM-216) mediates G2/M cell cycle arrest and potentiates apoptosis via multiple death pathways in colorectal cancer cells thus overcoming platinum chemo-resistanceQ53304624
Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancerQ54159355
Effects of cisplatin on the induction of apoptosis in proliferating hepatoma cells and nonproliferating immature thymocytesQ58283085
Cisplatin in cancer therapy: molecular mechanisms of actionQ34098163
Long-term cisplatin exposure impairs autophagy and causes cisplatin resistance in human lung cancer cellsQ34141265
Synthetic lethality: General principles, utility and detection using genetic screens in human cellsQ34151015
Tailoring mTOR-based therapy: molecular evidence and clinical challengesQ34294170
Induction of autophagy contributes to cisplatin resistance in human ovarian cancer cellsQ34540874
Ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibition is synthetically lethal in XRCC1 deficient ovarian cancer cellsQ34603025
eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206.Q35534450
NAC1 modulates sensitivity of ovarian cancer cells to cisplatin by altering the HMGB1-mediated autophagic responseQ35745292
Wee-1 kinase inhibition overcomes cisplatin resistance associated with high-risk TP53 mutations in head and neck cancer through mitotic arrest followed by senescenceQ36020559
Enhancement of synthetic lethality via combinations of ABT-888, a PARP inhibitor, and carboplatin in vitro and in vivo using BRCA1 and BRCA2 isogenic modelsQ36552134
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Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinomaQ36725301
Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells, distinct from cisplatinQ37043064
Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells.Q37073574
Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK.Q37342850
Protective effect of metalloporphyrins against cisplatin-induced kidney injury in miceQ37479069
Targeting cancer cells through autophagy for anticancer therapyQ37670439
The protein disulfide isomerases PDIA4 and PDIA6 mediate resistance to cisplatin-induced cell death in lung adenocarcinomaQ37689423
Molecular mechanisms of cisplatin resistanceQ37926477
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The machinery of macroautophagyQ38173673
The four faces of autophagy: implications for cancer therapyQ38181453
Targeting the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway: an emerging treatment strategy for squamous cell lung carcinomaQ38230994
Synthetic lethal vulnerabilities of cancerQ38262217
Applying synthetic lethality for the selective targeting of cancer.Q38263612
The role of DNA repair pathways in cisplatin resistant lung cancerQ38280128
HMGB1 promotes drug resistance in osteosarcomaQ38330106
A reversible gene-targeting strategy identifies synthetic lethal interactions between MK2 and p53 in the DNA damage response in vivoQ38411451
Induction of autophagy counteracts the anticancer effect of cisplatin in human esophageal cancer cells with acquired drug resistanceQ38955141
MCL-1 dependency of cisplatin-resistant cancer cellsQ38967669
Cisplatin-mediated radiosensitization of non-small cell lung cancer cells is stimulated by ATM inhibition.Q38992228
miR-205 impairs the autophagic flux and enhances cisplatin cytotoxicity in castration-resistant prostate cancer cellsQ39039757
Autophagy inhibition sensitizes cisplatin cytotoxicity in human gastric cancer cell line SGC7901.Q39089314
Cisplatin-induced downregulation of SOX1 increases drug resistance by activating autophagy in non-small cell lung cancer cellQ39101898
P433issue17
P407language of work or nameEnglishQ1860
P921main subjectautophagyQ288322
cisplatinQ412415
P1104number of pages15
P304page(s)15551-15565
P577publication date2015-06-01
P1433published inOncotargetQ1573155
P1476titleExploiting the potential of autophagy in cisplatin therapy: A new strategy to overcome resistance
P478volume6

Reverse relations

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