Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation

scientific article published on 29 May 2015

Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JNC.13182
P698PubMed publication ID26031312
P5875ResearchGate publication ID277336324

P2093author name stringZhihong Xu
Lin Guo
Xuechu Zhen
Zhuang Wu
Linlang Li
Long-Tai Zheng
P2860cites workDehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) as neuroactive neurosteroidsQ24613275
Does neuroinflammation fan the flame in neurodegenerative diseases?Q27498993
SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activityQ28295413
Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor-dependent inhibition of glycogen synthase kinase-3 beta and a receptor-independent anti-oxidative actionQ28578951
Sigma receptor ligand, (+)-pentazocine, suppresses inflammatory responses of retinal microgliaQ33702917
Pharmacology of signaling induced by dopamine D(1)-like receptor activationQ34126949
Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeysQ34247503
SKF83959 is a potent allosteric modulator of sigma-1 receptorQ34321224
Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after strokeQ34428140
Microglial activation state exerts a biphasic influence on brain endothelial cell proliferation by regulating the balance of TNF and TGF-β1.Q34467962
Targeting sigma-1 receptor signaling by endogenous ligands for cardioprotectionQ34626137
Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligandQ34655101
Targeting ligand-operated chaperone sigma-1 receptors in the treatment of neuropsychiatric disordersQ34795242
Role of p38 and p44/42 mitogen-activated protein kinases in microgliaQ34963708
Microglial and macrophage polarization—new prospects for brain repairQ35394922
The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elementsQ35856904
Allosteric modulation of G protein-coupled receptors: perspectives and recent developmentsQ35902519
Neurosteroid biosynthesis in the brain of amphibiansQ35971548
Dual role of inflammation in CNS diseaseQ36840391
In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocineQ36925899
Neurotransmitter receptors on microglia.Q36955350
D5 dopamine receptors are required for dopaminergic activation of phospholipase C.Q37199115
The pharmacology of sigma-1 receptorsQ37445561
Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression.Q38050292
Microglial phagocytosis of live neuronsQ38197408
Microglia and inflammation: conspiracy, controversy or control?Q38227727
Neuroimmune regulation of microglial activity involved in neuroinflammation and neurodegenerative diseasesQ38236853
Antiinflammatory effects of orientin-2"-O-galactopyranoside on lipopolysaccharide-stimulated microgliaQ38969184
Modulation of Ca2+ signals by phosphatidylinositol-linked novel D1 dopamine receptor in hippocampal neuronsQ42496753
Sigma receptors suppress multiple aspects of microglial activationQ43116456
SKF83959 exhibits biochemical agonism by stimulating [(35)S]GTP gamma S binding and phosphoinositide hydrolysis in rat and monkey brainQ43614902
SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals?Q43862501
SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brainQ44390567
D1-like dopamine receptor-mediated function in congenic mutants with D1 vs. D5 receptor "knockout".Q45134892
The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959.Q46429865
Dopamine and noradrenaline control distinct functions in rodent microglial cells.Q46467964
Dehydroepiandrosterone (DHEA) metabolism in the brain: identification by liquid chromatography/mass spectrometry of the delta-4-isomer of DHEA and related steroids formed from androstenedione by mouse BV2 microgliaQ46734673
1-O-tigloyl-1-O-deacetyl-nimbolinin B inhibits LPS-stimulated inflammatory responses by suppressing NF-κB and JNK activation in microglia cellsQ46867127
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmicrogliaQ1622829
allosteric inhibitorQ70361704
P304page(s)904-914
P577publication date2015-05-29
P1433published inJournal of NeurochemistryQ6295643
P1476titleAllosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation
P478volume134

Reverse relations

cites work (P2860)
Q39151414Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death
Q29248190Activation of the Sigma-1 receptor by haloperidol metabolites facilitates brain-derived neurotrophic factor secretion from human astroglia
Q64075641Allosteric Modulators of Sigma-1 Receptor: A Review
Q47731890Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation
Q41532363Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense.
Q91895094Network topology dynamics of circulating biomarkers and cognitive performance in older Cytomegalovirus-seropositive or -seronegative men and women
Q39190524Potential Roles of Mitochondria-Associated ER Membranes (MAMs) in Traumatic Brain Injury
Q44345660Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome.
Q38736252Recent Advances in the Realm of Allosteric Modulators for Opioid Receptors for Future Therapeutics
Q38896662Role of σ1 Receptors in Learning and Memory and Alzheimer's Disease-Type Dementia
Q57191691Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases
Q38743350Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection
Q41647730Sigma-1 receptor and neuroprotection: current outlook and potential therapeutic effects
Q50973291The Role of Sigma-1 Receptor, an Intracellular Chaperone in Neurodegenerative Diseases.
Q92617285The Roles of Intracellular Chaperone Proteins, Sigma Receptors, in Parkinson's Disease (PD) and Major Depressive Disorder (MDD)
Q57476258The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD

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